Pseudolymphoma of the Pancreas Mimicking Cancer

Hatzitheoklitos, Efthimios; Büchler, Markus W.; Friess, Helmut; Disebastiano, Perluigi; Poch, Bertram; Beger, H. G.; Mohr, W.

doi:10.1097/00006676-199409000-00020

Cited by 20 publications

(24 citation statements)

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“…The administrations of anticonvulsant or vaccine have been suggested as etiologies in some cases of pseudolymphoma [7,8], however, the present case and the previous two cases of pancreatic pseudolymphoma [1,2] did not have such histories.…”

Section: Discussioncontrasting

confidence: 79%

“…The pancreatic parenchyma was demonstrated to be adjacent to the pseudolymphoma and generally intact, and no particular findings relevant to lesion formation such as ulceration or lithiasis were observed. The second case, reported by Hatzitheoklitos et al in 1994, was a 68-year old woman who complained of malaise and a 5 kg weight loss [2]. She was found with abdominal ultrasonography to have a 5 Â 2.5 cm hypoechoic mass of the pancreatic body.…”

Section: Discussionmentioning

confidence: 94%

“…The most common symptoms of PPL are abdominal pain (83%), abdominal mass (58%), and weight loss (50%) [16]. Weight losses were observed in both of the patients with pancreatic pseudolymphoma previously reported [1,2]. LDH is thought as essential serum marker for PPL.…”

Section: Discussionmentioning

confidence: 99%

“…Pseudolymphoma of the pancreas is a very rare, with only two cases published so far in the English language case reports [1,2]. It remains difficult to distinguish pseudolymphoma from malignant disease, even with recent improved diagnostic modalities.…”

Section: Introductionmentioning

confidence: 99%

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Spontaneously complete regression of pseudolymphoma of the remnant pancreas after pancreaticoduodenectomy

Nakata¹,

Amano²,

Matsuoka³

et al. 2012

Pancreatology

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Section: Discussioncontrasting

confidence: 79%

Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Spontaneously complete regression of pseudolymphoma of the remnant pancreas after pancreaticoduodenectomy

Nakata¹,

Amano²,

Matsuoka³

et al. 2012

Pancreatology

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“…Two variants of autoimmune pancreatitis have been identified, type 1 autoimmune pancreatitis, an IgG4 related disease, and type 2 autoimmune pancreatitis, a disease characterized by granulocytic epithelial lesions [1–4]. A 3 rd form of pancreatitis characterized by a chronic inflammatory infiltrate and lymphoid follicles bearing prominent germinal centers, follicular pancreatitis, has not been as well characterized [5–10]. …”

Section: Introductionmentioning

confidence: 99%

Follicular pancreatitis: a distinct form of chronic pancreatitis—an additional mimic of pancreatic neoplasms

et al. 2016

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Follicular pancreatitis is a recently described variant of chronic pancreatitis characterized clinically by the formation of a discrete pancreatic mass and histologically by the presence of florid lymphoid aggregates with reactive germinal centers. Our aim was to study the clinical and histologic features of follicular pancreatitis, as well as to critically examine potential overlap with autoimmune pancreatitis. Immunohistochemistry for Bcl-2, CD21, kappa and lambda light chains as well as IgG4 and IgG were performed. We found a total of six patients (male:female = 2:1, mean age = 57 years) who fulfilled the diagnosis of follicular pancreatitis in our institutions. Four had an incidental diagnosis while two presented with abdominal pain, fatigue and elevated liver enzymes. On imaging, three patients had a discrete solid mass while 2 cases showed a dilated main pancreatic duct, mimicking an intraductal pancreatic mucinous neoplasm on imaging. One patient had a lesion in the intra-pancreatic portion of the common bile duct. On histopathology, all cases showed numerous lymphoid follicles with Bcl-2 negative germinal centers either in a periductal or in a more diffuse (periductal and intra-parenchymal) fashion, but without attendant storiform fibrosis, obliterative phlebitis or granulocytic epithelial lesions. IgG4/IgG ratio was <40% in all 6 cases. A comparison cohort revealed germinal centers in 25% of type 1 autoimmune pancreatitis and 2% of type 2 autoimmune pancreatitis cases, but none were periductal in location. In conclusion, follicular pancreatitis, an under-recognized mimic of pancreatic neoplasms is characterized by intrapancreatic lymphoid follicles with reactive germinal centers.

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