Pseudoexfoliation Syndrome and Associated Factors Among Adults at Gondar University Comprehensive Specialized Hospital Tertiary Eye Care and Training Center: A Cross-Sectional Study

Abstract

Background: Pseudoexfoliation syndrome is an age-related disorder characterized by the deposition of a distinct fibrillar extracellular material in various tissues and organs of the body. Glaucoma and cataract are the consistently reported clinical consequences of Pseudoexfoliation syndrome on the eye. This study aimed to estimate the proportion of pseudo-exfoliation syndrome and associated factors in Gondar university comprehensive specialized hospital tertiary eye care and training center. Methods and Materials: Institution-based cross-sectional study was conducted from January to March 2019 at Gondar university comprehensive specialized hospital tertiary eye care and training center among 295 patients. Consecutive 295 participants aged above 40 years were involved in the study. A structured questionnaire and ocular examination were used to collect the data. Data were entered into EPI-INFO 3.5.1 and exported to SPSS version 20 for analysis. Factors associated with pseudoexfoliation syndrome were ascertained by chi-square and independent t-test. Statistical significance was considered when p-value <0.05. Results: A total of 295 adults participated in the study with a response rate of 92.8%. The median (±IQR) age of study respondents was 64(±9) years and 67.8% were males. The proportion pseudoexfoliation syndrome was 34.6% [95% CI: 29.2-40.7%]. The mean IOP and mean age were significantly higher among patients with pseudoexfoliation syndrome. Age, sex, high IOP, glaucoma, outdoor work, and rural residence were significantly associated with the proportion of pseudoexfoliation syndrome. Conclusion:The proportion of pseudoexfoliation syndrome among participants aged ≥40 years was high. Age, sex, high IOP, glaucoma, outdoor work, and rural residence were factors having a significant association with the proportion of pseudoexfoliation syndrome.

Is There an Association Between Pseudoexfoliation and Pterygium? An Observational Study in a Semi-arid District of South India

“…This age trend was comparatively higher than the other studies [ 1 , 15 ]. At the same time, many studies also support the fact that the risk of PXF increases with age, and a possible explanation for this may be decreased gene expression with the increase in age, which in turn causes PXF [ 5 , 6 , 14 , 16 ].…”

Magnitude of Maladaptive Coping Strategy and Its Associated Factors Among Adult Glaucoma Patients Attending Tertiary Eye Care Center in Ethiopia

“…2,5 There is little research on the scope and contributing variables of MCS among glaucoma patients despite the higher prevalence of glaucoma and prevalent mental illnesses among glaucoma patients in Ethiopia. [17][18][19] Additionally, studies conducted in Africa and other regions of the world indicate that the magnitude of MCS is substancially high among glaucoma patients, and that there are significant differences between the reported magnitude of MCS among glaucoma patients in Africa and other regions of the world.…”