Pseudoepitheliomatous hyperplasia: A clinical entity mistaken for squamous cell carcinoma

Chakrabarti, Subrata; Chakrabarti, Preeti Rihal; Agrawal, Deepak; Somanath, Shreyas

doi:10.4103/0974-2077.150787

Cited by 16 publications

(10 citation statements)

References 11 publications

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“…5,7,8 Limitation of incision biopsy should be uppermost in the mind of the clinician and the need for a repeat deeper biopsy to include multiple sites (central areas and the margins the) down to the subcutaneous tissue before a definitive diagnosis is made, is essential whenever there is a clinico-pathologic discrepancy. 9,10 This happened to be the case with the index patient. A careful search for a possible ongoing infective process should be done with examination of deeper levels and use of microbiological special stains.…”

Section: Discussionmentioning

confidence: 98%

Psuedoepitheliomatous Hyperplasia Mimicking Squamous Cell Cancer in a Post-burn Scalp Wound: Case Report and Review of Literature

Isiwele¹,

Otei²,

Omoruyi³

et al. 2019

IJCMR

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Introduction: Pseudoepitheliomatous hyperplasia is a benign condition characterized by hyperplasia of the epidermis and adnexal epithelium commonly occurring in reaction to several conditions including chronic burn wound. Case Report: An 18 month old male patient presented with scald burns to the scalp and face with chronicity and infection of the burn wound as consent for skin grafting was not given by the parents. Initial histology of incision biopsy specimen revealed a well-differentiated squamous cell carcinoma in a chronic burn wound on the scalp. This did not correlate with the clinical picture of the wound necessitating a second histologic review of the biopsy specimen, which this time was confirmed as pseudoepitheliomatous hyperplasia. Patient further declined excision and grafting with the wound eventually healing with scarring after 10 months. Conclusion: A very high index of suspicion is required in making the diagnosis of PEH. Public enlightenment is needed to educate people on wounds and their management if optimal results must be obtained.

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Section: Discussionmentioning

confidence: 98%

Psuedoepitheliomatous Hyperplasia Mimicking Squamous Cell Cancer in a Post-burn Scalp Wound: Case Report and Review of Literature

Isiwele¹,

Otei²,

Omoruyi³

et al. 2019

IJCMR

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“…PEH may be primary (e.g., primal gingival PEH) or secondary (e.g., granular cell tumor or chronic irritation). [1] It can be a result of various conditions such as infections, inflammation, trauma, and malignancy and is also referred to as pseudocarcinomatous hyperplasia. Usually, PEH appears as a well-demarcated plaque or nodule with scaling and crusting.…”

Section: Discussionmentioning

confidence: 99%

Pseudoepitheliomatous Hyperplasia: A Diagnostic Dilemma

Chauhan

Gupta

Chauhan³

2018

Indian Journal of Medical and Paediatric Oncology

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Pseudoepitheliomatous hyperplasia (PEH) is a benign reactive inflammatory reaction of the epithelial cells to various conditions. It is a diagnostic dilemma which simulates malignancy, especially squamous cell carcinoma (SCC). Many articles of PEH involving the oral mucosa are available on the internet, but ocular involvement is infrequent. The ocular lesion in our case resembled SCC but turned out to be PEH. We report a rare case of PEH in a 20-year-old male.

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“…The benign nature of PEH means that most cases are resolved by means of excision biopsy, although grafts or flaps are occasionally needed to reconstruct major tissue defects [ 3 , 5 , 6 ]. On occasions, due to the different underlying causes, a biopsy is not sufficient, and etiological treatment is required, depending on each of the pathologies mentioned in the introduction [ 1 – 3 ].…”

Section: Discussionmentioning

confidence: 99%

Pseudoepitheliomatous Hyperplasia of the Larynx Requiring Total Laryngectomy

et al. 2018

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Patient: Male, 57Final Diagnosis: Pseudoepitheliomatous hyperplasiaSymptoms: DysphoniaMedication: —Clinical Procedure: Progressive speudoepitheliomaous hyperplasia spreadedSpecialty: OncologyObjective:Unusual clinical courseBackground:Pseudoepitheliomatous hyperplasia (PEH) is a reactive epithelial proliferation occurring secondary to infection, neoplasm, injury, and inflammation. The histopathological characteristics of PEH may lead to it being confused with well-differentiated squamous cell carcinoma (SCC).Case Report:We present here the case of a 57-year-old male patient, who was diabetic and a smoker, who presented with dysphonia. Although nasal endoscopy suggested SCC, morphological and immunophenotypical study of biopsy tissue ruled out malignancy.Conclusions:As the prognosis worsened, the patient required several urgent surgical interventions due to bleeding abscesses and dyspnea. A total laryngectomy was performed.

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Pseudoepitheliomatous hyperplasia: A clinical entity mistaken for squamous cell carcinoma

Cited by 16 publications

References 11 publications

Psuedoepitheliomatous Hyperplasia Mimicking Squamous Cell Cancer in a Post-burn Scalp Wound: Case Report and Review of Literature

Psuedoepitheliomatous Hyperplasia Mimicking Squamous Cell Cancer in a Post-burn Scalp Wound: Case Report and Review of Literature

Pseudoepitheliomatous Hyperplasia: A Diagnostic Dilemma

Pseudoepitheliomatous Hyperplasia of the Larynx Requiring Total Laryngectomy

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