Pseudoangiosarcomatous carcinoma of the genitourinary tract.

Pitt, Mark A.; Morphopoulos, G; Wells, S; Bisset, D.L.

doi:10.1136/jcp.48.11.1059

Cited by 22 publications

(19 citation statements)

References 9 publications

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“…[1] PASCC has been reported in the head and neck,[2] as well as in the other organs, such as the breast,[3] lungs,[4] urinary bladder,[5] vulva, and uterine cervix. [6] Only two cases of PASCC arising from the upper aerodigestive tract have been reported so far.…”

Section: Introductionmentioning

confidence: 99%

Pseudovascular adenoid squamous cell carcinoma of oral cavity: A mimicker of angiosarcoma

Vidyavathi

Prasad

Kumar

et al. 2012

J Oral Maxillofac Pathol

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Pseudovascular adenoid squamous cell carcinoma (PASCC) is an uncommon histological variant of squamous cell carcinoma that can mimic vascular neoplasms, particularly angiosarcoma, in its morphologic characteristics. PASCC has been reported in the head and neck, as well as in the other organs such as the breast, lungs, urinary bladder, vulva, and uterine cervix. Only two cases of PASCC arising from the upper aerodigestive tract have been reported so far. We report a case of PASCC of oral cavity in a 40-year-old man, which mimicked an angiosarcoma initially. Immunohistochemical analysis led to a conclusive diagnosis of PASCC.

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Section: Introductionmentioning

confidence: 99%

Pseudovascular adenoid squamous cell carcinoma of oral cavity: A mimicker of angiosarcoma

Vidyavathi

Prasad

Kumar

et al. 2012

J Oral Maxillofac Pathol

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“…We believe that the pseudoangiosarcomatous change in these bladder carcinomas is analogous to those previously described in other organ site carcinomas. [1][2][3][4][5][6] The urothelial phenotype in these pseudoangiosarcomatous carcinomas is supported by the diffuse CK7 immunostaining, nuclear GATA3 expression, negativity for vascular markers, and, more evidently, their continuity with identifiable intact urothelial carcinoma areas. Interestingly, all 7 pseudoangiosarcomatous carcinomas in our series had admixed urothelial carcinoma variant morphologies that included squamous differentiation, sarcomatoid spindle cell, small cell, micropapillary, and glandular differentiation morphologies.…”

Section: Discussionmentioning

confidence: 99%

“…[1][2][3][4][5][6] These carcinomas were also reported under different eponyms such as acantholytic, pseudovascular, angiosarcoma-like, pseudoglandular, adenoid squamous, and pseudovascular adenoid squamous carcinomas. 1,2,5,[7][8][9][10][11][12][13][14] Most of the pseudoangiosarcomatous carcinomas previously described were squamous cell carcinomas from various organ sites such as the skin, 2-4,13 conjunctiva, 15 aerodigestive mucosa, 11,16 lungs, 3,12 breast, 3,9,10 cecum, 7 vulva, 5,6,8 uterine cervix, 14 and penis. 17 The pseudoangiosarcomatous pattern has also been described in poorly differentiated and sarcomatoid ductal carcinoma of the breast.…”

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confidence: 98%

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Pseudoangiosarcomatous Urothelial Carcinoma of the Urinary Bladder

Paner

Cox

Richards

et al. 2014

American Journal of Surgical Pathology

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The pseudoangiosarcomatous pattern has been described mostly in cutaneous and some visceral squamous cell carcinomas and is unique for its striking morphologic resemblance to angiosarcoma. Herein, we describe the clinicopathologic features of 7 pseudoangiosarcomatous urothelial carcinomas that occurred in the urinary bladder. The patients included 6 men and 1 woman ranging in age from 47 to 87 years (median 70 y). The pseudoangiosarcomatous morphology was observed in 7 urothelial carcinomas including 3 with squamous differentiation and comprised 35% to 85% of the invasive tumor. Histologically, the pseudoangiosarcomatous carcinomas were characterized by tumor cell discohesion and lysis that created pseudolumina formations surrounded by attached residual tumor cells. Detached degenerating tumor cells variably admixed with inflammatory cells were common in the false lumina. Partly intact urothelial carcinoma nests contained irregular or cleft-like spaces and disintegrating tumor cells with stretched intercellular bridges. The tumor was commonly associated with a dense collagenous matrix, often surrounding the lytic nests. Similar tumor cell discohesion and breakdown were observed in 3 tumors with foci of squamous cell differentiation, distinguished by the presence of dyskeratosis and keratin formation. All 7 tumors contained other nonpseudoangiosarcomatous carcinoma components such as conventional urothelial carcinoma (5), squamous differentiation (4), sarcomatoid spindle cell carcinoma (2), small cell carcinoma (1), micropapillary carcinoma (1), and glandular differentiation (1). The pseudoangiosarcomatous urothelial carcinomas were all (7/7) diffusely CK7 positive, most (6/7) were GATA3 positive, and none (0/7) expressed vascular-associated markers. There was no evidence to suggest that apoptosis (by TUNEL assay and cleaved caspase-3 immunostaining) or loss of the adhesion molecules CD138 and e-cadherin were possible causes for the tumor cell discohesion and breakdown. All 7 tumors were high stage at cystectomy and included 1 pT3a, 2 pT3b, and 4 pT4a tumors, and 3 had pelvic lymph node involvement. Follow-up data available in 6 cases revealed a poor outcome with an overall median survival of 8.5 months. In conclusion, we present an unusual morphology of bladder carcinoma that has a striking resemblance to a malignant vasoformative tumor. Our series showed that bladder pseudoangiosarcomatous carcinoma morphology is associated with a higher tumor stage at cystectomy, commonly admixed with other aggressive carcinoma variant morphologies, and portend a poorer outcome. Knowledge of this pattern is also important to avoid misdiagnosis, particularly in limited tissue samples.

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“…69,70 One patient in our series with vulvar LC (vulvar vascular lymphatic reaction pattern type) occurring in the setting of chronic lymphedema secondary to lymphadenectomy and radiation therapy developed vaginal angiosarcoma; however, there are no contemporary reports of malignant transformation within the vulva of vulvar LC. 71,72 Malignant tumors mimicking vascular lesions include pseudoangiosarcomatous squamous cell carcinoma, an unusual but aggressive variant of acantholytic squamous cell carcinoma, [73][74][75] and monophasic synovial sarcoma with prominent hemangiopericytoma-like vascular pattern. 71,72 These studies point to the development of the potential usefulness of markers such as MYC in diagnosing these tumors.…”

Section: Malignant Neoplasmsmentioning

confidence: 99%

Vulvar Vascular Tumors

Papalas¹,

Sangüeza²,

Puri

et al. 2013

The American Journal of Dermatopathology

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The subepidermal hormonally sensitive tissue of the vulva is anatomically unique and may give rise to a wide variety of vascular tumors. As a consequence, classifying vulvar vascular lesions has been challenging due both to the wide variety of lesions that may be encountered and the heterogeneity in reporting across several disciplines. The purpose of this study is to present an institutional experience of vulvar vascular lesions. Overall, 85 patients were identified over a 26-year period. Vascular lesions belonging to the following classes included (n, %total) benign vascular tumors (32, 38%), dilatations of preexisting vessels (31, 36%), hyperplasia/reactive (7, 8%), tumors with significant vascular component (11, 13%), malformations (3, 4%), and malignant vascular tumors (1, 1%). Two reaction patterns based on vulvar lymphatic pathology were identified: one is a stromal dominant pattern and the other is a vascular dominant pattern. Vulvar vascular malformations and true vascular malignancies, although rare, may have associated high morbidity. To accurately classify vulvar lymphatic lesions, the pathologist must carefully consider the patient's clinical history taking into account features such as preexisting lymphedema.

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Pseudoangiosarcomatous carcinoma of the genitourinary tract.

Cited by 22 publications

References 9 publications

Pseudovascular adenoid squamous cell carcinoma of oral cavity: A mimicker of angiosarcoma

Pseudovascular adenoid squamous cell carcinoma of oral cavity: A mimicker of angiosarcoma

Pseudoangiosarcomatous Urothelial Carcinoma of the Urinary Bladder

Vulvar Vascular Tumors

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