Pseudoangiomatous stromal hyperplasia of the breast: a case report of a 12-year-old girl

Almohawes, Eman; Khoumais, Nuha; Arafah, Maria

doi:10.1016/j.radcr.2015.06.007

Cited by 12 publications

(13 citation statements)

References 13 publications

(15 reference statements)

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“…1 While the precise aetiology of this condition is not yet well understood, a hormonal cause has been proposed. 1,2 This is supported by the fact that the majority of patients with PASH are premenopausal. 2 In addition, the use of oral contraceptives and hormonal replacement therapy have been implicated.…”

Section: Commentmentioning

confidence: 93%

“…1,2 This is supported by the fact that the majority of patients with PASH are premenopausal. 2 In addition, the use of oral contraceptives and hormonal replacement therapy have been implicated. 2,3 The current case is interesting for several reasons.…”

Section: Commentmentioning

confidence: 93%

“…2 In addition, the use of oral contraceptives and hormonal replacement therapy have been implicated. 2,3 The current case is interesting for several reasons. First, the atypical clinical presentation of PASH in the patient initially indicated focal inflammatory or granulomatous mastitis or an inflammatory breast carcinoma.…”

Section: Commentmentioning

confidence: 99%

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Pseudoangiomatous Stromal Hyperplasia: A rare mimic of breast malignancy

Michael

Al-Saadi

Jamkhandikar

et al. 2017

SQUMJ

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A 48-year-old premenopausal woman presented to the Breast Clinic of the Armed Forces Hospital, Muscat, Oman, in 2015 with a one-year history of a lump in her right breast which was progressively increasing in size. She had no associated fever or nipple discharge. The patient had three children whom she had breastfed normally. She was not lactating at the time of presentation and did not have a history of previous breast-related surgeries or trauma. On clinical examination, the right breast was found to be enlarged and diffusely erythematous with prominent superficial veins and skin changes. There was a palpable non-tender mass measuring approximately 1.5 x 2.5 cm in size which was suspected to be malignant (i.e. an inflammatory carcinoma). The axillary lymph nodes were not palpable.Mammography and ultrasonography of both breasts was performed. The mammogram revealed a lesion in the right breast which was rounded with slightly lobulated margins [ Figure 1]. The lesion was classified as Breast Imaging-Reporting and Data System category 4. No microcalcifications were evident. The ultrasound scan showed a 1.5 x 2.5 cm hypoechoic mass in the same location as that of the mammographic abnormality [ Figure 2]. A colour Doppler ultrasound did not show any flow within the lesion. Radiologically, the appearance of the lesion was suggestive of a fibroadenoma or phyllodes tumour. However, due to concern that the lesion might be malignant, a histopathological examination was advised. Fine-needle aspiration cytology results were equivocal. Subsequently, an ultrasound-guided core biopsy of the lesion revealed the presence of spindle cells in a pseudoangiomatous pattern within the fibrous tissue [ Figure 3]. This confirmed the diagnosis of pseudoangiomatous stromal hyperplasia (PASH). The lesion was surgically excised through a small incision with excellent postoperative cosmetic results. The patient was followed-up for two years without evidence of recurrence. interesting medical image

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Section: Commentmentioning

confidence: 93%

Section: Commentmentioning

confidence: 93%

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Pseudoangiomatous Stromal Hyperplasia: A rare mimic of breast malignancy

Michael

Al-Saadi

Jamkhandikar

et al. 2017

SQUMJ

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“…Betroffen sind meist perimenopausale Frauen (Durchschnittsalter 40 J.). In der postmenopausalen Phase ist die PASH möglicherweise mit Hormonersatztherapien assoziiert [1,4].…”

Section: Diagnostikunclassified

“…Die PASH ist eine benigne myofibroblastische Läsion der Mamma, die durch Proliferation stromaler mesenchymaler Zellen myofibroblastischen Ursprungs charakterisiert ist. Diese bilden von Myofibroblasten ummantelte Hohlräume, die Gefäßstrukturen nachahmen [1,4].…”

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