Pseudoangiomatous Stromal Hyperplasia: Imaging Findings With Pathologic and Clinical Correlation

Jones, Katie N.; Glazebrook, Katrina N.; Reynolds, Carol

doi:10.2214/ajr.09.3284

Cited by 82 publications

(86 citation statements)

References 13 publications

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“…Histological analysis shows dense breast stromal tissue containing a complex pattern of linear spaces caused by the separation of collagen fibrils, which resemble vascular spaces (hence the name "pseudoangiomatous") and they may suggest a low grade malignant angiosarcoma (distinction is achieved by immunohistochemical markers for vascular tumors) [50,51].…”

Section: Other Stromal Proliferationsmentioning

confidence: 99%

Benign breast lesions: Ultrasound

Masciadri

Ferranti

2011

Journal of Ultrasound

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KEYWORDSBreast; Ultrasound; Benign breast lesions.Abstract Benign breast diseases constitute a heterogeneous group of lesions arising in the mammary epithelium or in other mammary tissues, and they may also be linked to vascular, inflammatory or traumatic pathologies. Most lesions found in women consulting a physician are benign. Ultrasound (US) diagnostic criteria indicating a benign lesion are described as well as US findings in the most frequent benign breast lesions.Sommario Le lesioni mammarie benigne costituiscono un gruppo eterogeneo di manifestazioni, sia proprie dell'epitelio mammario, sia con origine dagli altri tessuti che costituiscono l'organo, sia con altra patogenesi (vascolare, flogistica e traumatica). Esse costituiscono il reperto più frequente che si osserva nella maggior parte dei casi nei quali una donna pensa di avere un problema al seno e si rivolge al medico o al radiologo. Vengono riproposti da un punto di vista ecografico i criteri diagnostici che orientano per la benignità ed i quadri iconografici che si riscontrano nelle principali lesioni mammarie benigne ecograficamente identificabili. ª

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Section: Other Stromal Proliferationsmentioning

confidence: 99%

Benign breast lesions: Ultrasound

Masciadri

Ferranti

2011

Journal of Ultrasound

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Section: Pseudoangiomatous Stromal Hyperplasiamentioning

confidence: 99%

“…4 However, case reports of lesions with irregular, illdefined or spiculated margins have been described, making it difficult to exclude the possibility of malignancy based on imaging alone. [3][4][5] Several factors influence the management of PASH. For lesions that are small, asymptomatic and unequivocally confirmed by biopsy, surgical excision can be avoided; in contrast, surgery is indicated for larger lesions, for patients where the preoperative histology cannot confirm a diagnosis or in cases with suspicious clinical or radiological features.…”

Section: Pseudoangiomatous Stromal Hyperplasiamentioning

confidence: 99%

“…3 A preoperative diagnosis of PASH based on fine-needle aspiration cytology is not possible since the results are non-specific; a core biopsy may help to establish the diagnosis, although in some cases a diagnosis can be made only after surgical excision. 4 Histologically, PASH is composed of complex interanastomosing slit-like spaces within the breast parenchyma lined by spindle cells. The absence of blood cells within these structures and the lack of cellular atypia or mitotic activity can help to differentiate PASH from low-grade angiosarcomas.…”

Section: Commentmentioning

confidence: 99%

“…[3][4][5] In equivocal cases, immunohistochemistry also plays a role in diagnosis since PASH lesions are positive for vimentin and cluster of differentiation (CD) 34 and negative for cytokeratins and factor VIIIrelated antigen. Interesting Medical Image | e249 Philips G. Michael, Tahra Al-Saadi, Rakesh Jamkhandikar and Lakshmi Rao…”

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confidence: 99%

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Pseudoangiomatous Stromal Hyperplasia: A rare mimic of breast malignancy

Michael

Al-Saadi

Jamkhandikar

et al. 2017

SQUMJ

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A 48-year-old premenopausal woman presented to the Breast Clinic of the Armed Forces Hospital, Muscat, Oman, in 2015 with a one-year history of a lump in her right breast which was progressively increasing in size. She had no associated fever or nipple discharge. The patient had three children whom she had breastfed normally. She was not lactating at the time of presentation and did not have a history of previous breast-related surgeries or trauma. On clinical examination, the right breast was found to be enlarged and diffusely erythematous with prominent superficial veins and skin changes. There was a palpable non-tender mass measuring approximately 1.5 x 2.5 cm in size which was suspected to be malignant (i.e. an inflammatory carcinoma). The axillary lymph nodes were not palpable.Mammography and ultrasonography of both breasts was performed. The mammogram revealed a lesion in the right breast which was rounded with slightly lobulated margins [ Figure 1]. The lesion was classified as Breast Imaging-Reporting and Data System category 4. No microcalcifications were evident. The ultrasound scan showed a 1.5 x 2.5 cm hypoechoic mass in the same location as that of the mammographic abnormality [ Figure 2]. A colour Doppler ultrasound did not show any flow within the lesion. Radiologically, the appearance of the lesion was suggestive of a fibroadenoma or phyllodes tumour. However, due to concern that the lesion might be malignant, a histopathological examination was advised. Fine-needle aspiration cytology results were equivocal. Subsequently, an ultrasound-guided core biopsy of the lesion revealed the presence of spindle cells in a pseudoangiomatous pattern within the fibrous tissue [ Figure 3]. This confirmed the diagnosis of pseudoangiomatous stromal hyperplasia (PASH). The lesion was surgically excised through a small incision with excellent postoperative cosmetic results. The patient was followed-up for two years without evidence of recurrence. interesting medical image

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Bilateral axillary pseudoangiomatous stromal hyperplasia in a premenopausal woman: A case report with imaging findings

Jung

Kim

2021

J of Clinical Ultrasound

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Pseudoangiomatous stromal hyperplasia is a benign proliferative mesenchymal lesion of the breast. To date, only a few cases of axillary pseudoangiomatous stromal hyperplasia with imaging findings have been reported in the literature. Herein, we report a rare case of pseudoangiomatous stromal hyperplasia in both axillae in a previously healthy 46-year-old woman and describe the imaging findings, including ultrasonography and computed tomography findings.

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Pseudoangiomatous Stromal Hyperplasia: Imaging Findings With Pathologic and Clinical Correlation

Cited by 82 publications

References 13 publications

Benign breast lesions: Ultrasound

Benign breast lesions: Ultrasound

Pseudoangiomatous Stromal Hyperplasia: A rare mimic of breast malignancy

Bilateral axillary pseudoangiomatous stromal hyperplasia in a premenopausal woman: A case report with imaging findings

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