Pseudoangiomatous stromal hyperplasia – a benign and rare tumor of the breast in an adolescent: a case report

Abstract

BackgroundPseudoangiomatous stromal hyperplasia is an uncommon mesenchymal breast neoplasm.Case presentationHere we present a case of an 11-year old hispanic girl affected by bilateral mammary nodular pseudoangiomatous stromal hyperplasia, an uncommon breast disease, with a review of the literature related to diagnostic workup, differential diagnosis, and management. A rapidly growing mass in the breast may be stressful for both parents and child as the suspicion of malignancy arises. Multiple wide excisions of both breasts were performed.ConclusionsThe purpose of this case report is to draw attention to the fact that most emerging lesions of the breast in girls during puberty are benign diseases.

Pseudoangiomatous Stromal Hyperplasia-Case Report of a Rare Breast Tumor in a Premenarchal Girl

“…7 A hormone-dependent stromal change has been the most acknowledged theory. 1,5,8 This is supported by the high prevalence of premenopausal women among patients suffering from PASH, in spite of that, there are sparce cases of the disease described in postmenopausal women and adolescents, as in the case we report. Nonetheless, the literature reports that most of the PASH tumors disclosed in postmenopausal women were in patients under hormone replacement therapy.…”

“…Nonetheless, the literature reports that most of the PASH tumors disclosed in postmenopausal women were in patients under hormone replacement therapy. 1 Progesterone receptors expressed on the nuclei of myofibroblasts in PASH cases, encourages the role of hormonal influence in its pathogenesis, as well. 9 Clinically, PASH can be mistaken for fibroadenoma, as a result of its nonspecific presentation and sonographic appearance.…”

“…With regard to nodular forms of PASH, wide excision remains the cornerstone of management. 1,4,10 Highly variable recurrence rates following excision have been reported, ranging from 0% to 29%, largely attributed to incomplete excision or presence of unknown multifocal lesions. 6,11 In our case, surgical excision was performed, with successful clinical and cosmetic results and no recurrence at 3-year follow-up.…”

Hiperplasia estromal pseudoangiomatosa de la mama tipo nodular: reporte de un caso

“…La PASH es una patología benigna, caracterizada por una red compleja de espacios en forma de hendidura, forrados por células de huso [1][2][3][4][5][6][7][8][9][10][11][12][13] . La presentación nodular de la PASH se encuentra en el 0.4% de las biopsias 11 .…”

“…La hiperplasia estromal pseudoangiomatosa (PASH) es una proliferación benigna del estroma mamario descrito por primera vez en 1986 por Vuitch, et al [1][2][3][4][5][6][7][8][9][10][11][12][13] . El término pseudoangiomatoso fue propuesto para enfatizar un patrón histológico que puede imitar proliferación vascular.…”