Pseudoangiomatous hyperplasia of male breast

Badve, S; Sloane, J P

doi:10.1111/j.1365-2559.1995.tb00255.x

Cited by 58 publications

(24 citation statements)

References 5 publications

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“…18 PASH is also a frequent incidental component of gynecomastia. 2 The pathogenesis of this lesion is attributed to hyperplasia of stromal myofibroblasts in response to hormonal stimuli. Myofibroblastic differentiation has been demonstrated by electron microscopic studies.…”

Section: Discussionmentioning

confidence: 99%

Pseudoangiomatous Stromal Hyperplasia in Lesions Involving Anogenital Mammary-Like Glands

Kazakov

Bisceglia²,

Mukenšnábl³

et al. 2005

American Journal of Surgical Pathology

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Pseudoangiomatous stromal hyperplasia (PASH), first reported in 1986, is nowadays a well-recognized change in the breast. We present three cases of lesions involving anogenital mammary-like glands demonstrating this feature. All patients were females (ages, 42, 43, and 53 years). Each presented with a solitary, 1.5- to 2-cm asymptomatic nodule. Locations included the perianal area, perineum, and labium majus. Histopathologically, one lesion was classified as low-grade phyllodes tumor, another as fibroadenoma, and in the remaining case PASH was found in the background of mild hyperplasia of anogenital mammary-like glands and substantial lipomatous metaplasia. In all lesions, PASH had an identical appearance to that in the breast, that is open, slit-like, often anastomosing channels devoid of erythrocytes and lined by discontinuous, often attenuated, inconspicuous cells without atypia or mitotic activity set in a hyalinized collagenous stroma. Quantitatively, PASH ranged in the above cases, forming a relatively small focus in the fibroadenoma and being quite extensive in the remaining two cases. In the phyllodes tumor, PASH areas exhibited focal hypercellularity and presence of myoid cells. In none of the cases were there cells with intranuclear inclusions or multinucleated cells. The lesions were surgically excised. Two patients with follow-up were disease-free at one and three years after the operation. As to our knowledge, PASH has not been previously described in the anogenital area, this feature seems to have been either overlooked or is genuinely rare in this location. It may occur in a preexisting lesion of anogenital mammary-like glands or may apparently by itself produce a clinically detectable lesion. The clinicopathologic features of PASH in the anogenital area seem to be identical to those in the breast.

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Section: Discussionmentioning

confidence: 99%

Pseudoangiomatous Stromal Hyperplasia in Lesions Involving Anogenital Mammary-Like Glands

Kazakov

Bisceglia²,

Mukenšnábl³

et al. 2005

American Journal of Surgical Pathology

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“…Whenever lymph needs to be drained, especially in inflammatory situations, pre-lymphatics open on demand [3]. Although Vuitch et al [6] believed that these spaces were artefact, Badve and Sloane [7] demonstrated that these same spaces are real, as they are visible in frozen sections as well as at ultrastructural level [4]. In addition, neoplastic cells were found to spread through them, highlighting the labyrinth structure of these same spaces [8].…”

Section: Introductionmentioning

confidence: 99%

The pre-lymphatic pathway, the rooths of the lymphatic system in breast tissue: a 3D study

et al. 2008

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Three-dimensional (3D) visualisation of microscopic structures provides useful information about their configuration and the spatial (hence functional) relationship between different components in tissues. This paper describes 3D dynamic reconstructions of the pre-lymphatic labyrinth in two cases of "normal" breast core biopsies and one case of pseudoangiomatous stromal hyperplasia. Direct anastomoses between pre-lymphatic channels and true lymphatics of the breast were demonstrated. It is concluded that pre-lymphatics are a way of communication between breast epithelial/stromal structures and the main lymphatic system. The present findings suggest that the existence of pre-lymphatics has to be taken in consideration in the intramammary spread of malignant tumours.

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“…[2][3][4][5] However, palpable masses and radiologically detected lesions consisting predominantly of pseudoangiomatous stromal hyperplasia cells are rare; the largest series reported in the medical literature includes 40 cases. 6 The imaging findings of pseudoangiomatous stromal hyperplasia tumors have been reported only in small case series.…”

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confidence: 99%

Pseudoangiomatous stromal hyperplasia tumor: a clinical, radiologic and pathologic study of 26 cases

Ferreira¹,

2008

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Pseudoangiomatous stromal hyperplasia tumors are rare. In this retrospective study, we evaluated the clinical, radiologic, and pathologic features of pseudoangiomatous stromal hyperplasia tumors and compared histologic findings of pseudoangiomatous stromal hyperplasia tumors with clinical outcome. We identified 26 patients (mean age, 47 years) with pseudoangiomatous stromal hyperplasia tumors who had been diagnosed at our institution. Sixteen patients (62%) were premenopausal, and 13 (50%) had a history of oral contraceptive or hormone replacement therapy use. Ten patients (38%) presented with a palpable mass; in the other patients, the tumors were detected by mammography (where it usually appeared as a hyperdense mass with irregular margins) or sonography (where it usually appeared as a hypoechoic mass). Lesions were a mean of 4.2 cm at the largest dimension (range, 0.8-11 cm). Histologically, pseudoangiomatous stromal hyperplasia was classified as simple in 18 patients (69%) and fascicular/proliferative in eight patients (31%). In one patient (4%), an invasive ductal carcinoma was present within the pseudoangiomatous stromal hyperplasia tumor. We found associated benign epithelial lesions in eight patients (31%) and/or gynecomastia-like changes in 17 patients (65%). The presence of gynecomastia-like changes was significantly associated with intralobular location of pseudoangiomatous stromal hyperplasia (P ¼ 0.00085, by Fisher's exact test). Follow-up data were available for 15 patients (mean±s.d., r27±17 months). No additional pathology or substantial changes in existing lesions were found on imaging. All pseudoangiomatous stromal hyperplasia tumors diagnosed by core needle biopsy but not subsequently excised remained clinically and radiologically stable; therefore, offering the option of close clinical surveillance instead of surgery in patients with pseudoangiomatous stromal hyperplasia tumors diagnosed by core needle biopsy in selected patients.

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Pseudoangiomatous hyperplasia of male breast

Cited by 58 publications

References 5 publications

Pseudoangiomatous Stromal Hyperplasia in Lesions Involving Anogenital Mammary-Like Glands

Pseudoangiomatous Stromal Hyperplasia in Lesions Involving Anogenital Mammary-Like Glands

The pre-lymphatic pathway, the rooths of the lymphatic system in breast tissue: a 3D study

Pseudoangiomatous stromal hyperplasia tumor: a clinical, radiologic and pathologic study of 26 cases

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