Pseudoaldosteronism Caused by Combined Administration of Cilostazol and Glycyrrhizin

Maeda, Yoshitaka; Inaba, Naoto; Aoyagi, Makoto; Tanase, Takehito; Shiigai, Tatsuo

doi:10.2169/internalmedicine.47.1080

Cited by 9 publications

(7 citation statements)

References 10 publications

(4 reference statements)

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“…These results suggest that SK is an effective herbal medicine for not only spontaneous contractions but also oxytocin‐ and PGF 2α ‐induced contractions in clinical critical situations and that the effect of SK on smooth muscle contractions is due to K. SK may decrease the risk of premature delivery caused by premature uterine contractions. However, it is necessary to use SK with caution because there are some reports that it increases the risk of pseudoaldosteronism with hypokalemia, hypertension, sodium and body fluid retention edema, and weight gain 18–21 . Further studies are needed before SK can be utilized for prevention of premature delivery.…”

Section: Discussionmentioning

confidence: 99%

Shakuyaku‐kanzo‐to inhibits smooth muscle contractions of human pregnant uterine tissue in vitro

Tsuji

Yasuda

Sumi

et al. 2012

J of Obstet and Gynaecol

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Section: Discussionmentioning

confidence: 99%

Shakuyaku‐kanzo‐to inhibits smooth muscle contractions of human pregnant uterine tissue in vitro

Tsuji

Yasuda

Sumi

et al. 2012

J of Obstet and Gynaecol

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“…The adverse reactions of MTX include nausea, vomiting, diarrhea, and hepatotoxicity [87,88]. A case report showed that combined administration of GA and cilostazol caused pseudoaldosteronism [89]. Therefore, the concurrent use of GA with MTX or cilostazol is not recommended.…”

Section: Inductive Effect Of Liver Enzymementioning

confidence: 99%

Glycyrrhizic Acid in the Treatment of Liver Diseases: Literature Review

Cao

Liu

et al. 2014

BioMed Research International

178

168

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Glycyrrhizic acid (GA) is a triterpene glycoside found in the roots of licorice plants (Glycyrrhiza glabra). GA is the most important active ingredient in the licorice root, and possesses a wide range of pharmacological and biological activities. GA coupled with glycyrrhetinic acid and 18-beta-glycyrrhetic acid was developed in China or Japan as an anti-inflammatory, antiviral, and antiallergic drug for liver disease. This review summarizes the current biological activities of GA and its medical applications in liver diseases. The pharmacological actions of GA include inhibition of hepatic apoptosis and necrosis; anti-inflammatory and immune regulatory actions; antiviral effects; and antitumor effects. This paper will be a useful reference for physicians and biologists researching GA and will open the door to novel agents in drug discovery and development from Chinese herbs. With additional research, GA may be more widely used in the treatment of liver diseases or other conditions.

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“…Pseudoaldosteronism is a well-known adverse reaction in patients receiving licorice and its more purified product, glycyrrhizic acid (GA) (15). A daily intake of 10 mg/day or 0.2 mg/kg/day of GA is considered safe for most healthy adults, using a safety factor of 10 (16,17).…”

Section: Discussionmentioning

confidence: 99%

Hyponatremia in an Elderly Patient due to Isolated Hypoaldosteronism Occurring after Licorice Withdrawal

et al. 2017

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Hyponatremia is one of the most common electrolyte disorders encountered in the elderly. We present the case of an 81-year-old man who developed hyponatremia due to isolated hypoaldosteronism occurring after licorice withdrawal. He had severe hypokalemia with hypertension and was diagnosed with pseudoaldosteronism. He had been taking a very small dose of licorice as a mouth refresher since his early adulthood. Five months after licorice withdrawal, he developed hypovolemic hyponatremia, which was resolved with administration of fludrocortisone acetate. Our experience with this case suggests that isolated hypoaldosteronism occurring after licorice withdrawal should be considered as a potential cause of hyponatremia in elderly patients.

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Pseudoaldosteronism Caused by Combined Administration of Cilostazol and Glycyrrhizin

Abstract: We report a case of obvious pseudoaldosteronism which occurred after the additional administration of cilostazol against arteriosclerosis obliterans (ASO)

Cited by 9 publications

References 10 publications

Shakuyaku‐kanzo‐to inhibits smooth muscle contractions of human pregnant uterine tissue in vitro

Shakuyaku‐kanzo‐to inhibits smooth muscle contractions of human pregnant uterine tissue in vitro

Glycyrrhizic Acid in the Treatment of Liver Diseases: Literature Review

Hyponatremia in an Elderly Patient due to Isolated Hypoaldosteronism Occurring after Licorice Withdrawal

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