1989
DOI: 10.1093/ajh/2.5.349
|View full text |Cite
|
Sign up to set email alerts
|

Pseudo Renal Artery Stenosis (PRAS) Syndrome

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

0
7
0

Year Published

1989
1989
2017
2017

Publication Types

Select...
8

Relationship

1
7

Authors

Journals

citations
Cited by 12 publications
(7 citation statements)
references
References 0 publications
0
7
0
Order By: Relevance
“…Despite this, the aldosterone secretion from the right adrenal is clearly unsuppressed as the level of aldosterone in the blood taken from around the right adrenal vein is higher than surrounding areas reflecting activation of the renin angiotensin system similar to that seen in unilateral renal artery stenosis. The same results can occur in hypertensive nephrosclerosis and Pettinger et al 21 have used the term pseudo renal artery stenosis to describe this occurrence on a background of hypertensive nephrosclerosis.…”
Section: Discussionmentioning
confidence: 75%
See 1 more Smart Citation
“…Despite this, the aldosterone secretion from the right adrenal is clearly unsuppressed as the level of aldosterone in the blood taken from around the right adrenal vein is higher than surrounding areas reflecting activation of the renin angiotensin system similar to that seen in unilateral renal artery stenosis. The same results can occur in hypertensive nephrosclerosis and Pettinger et al 21 have used the term pseudo renal artery stenosis to describe this occurrence on a background of hypertensive nephrosclerosis.…”
Section: Discussionmentioning
confidence: 75%
“…This can occur in bilateral renal artery stenosis, renal artery stenosis to a single kidney or in those with severe arteriolar disease. 21,22 This patient had a normal captopril renogram, which although is not the gold standard for diagnosis of renal artery stenosis (sensitivity 71-92%, [23][24][25][26], makes this diagnosis unlikely.…”
Section: Discussionmentioning
confidence: 99%
“…However, renal arteriographic studies were negative, suggesting a syndrome of pseudo renal artery stenosis. 29 We were unable to maintain the mean DBP at proposed levels in both groups of randomized patients after 2 years of good BP control. A similar observation was noted in the Framingham study 30 and other previous studies.…”
Section: Figure 2 P/o/ Of Changes In Quantity Of Antihypertensive Drmentioning
confidence: 85%
“…Thus, hyper-filtration cannot be a major mechanism of destroying kidney function in our patients as suggested by studies in rats (41,42). Minoxidil-induced hyper-filtration may, in fact, explain why hemodialysis may be discontinued in some minoxidil treated patients (44) and should be systematically studied for delay of, or reducing hemodialysis.Discovery of, and understanding of the mechanism of the PRAS Syndrome originally described for minoxidil (6) but subsequently found to be related to severe reversible loss of renal function with other antihypertensive drugs (43,44). (See below)…”
Section: Minoxidil and Saving The Kidneys In Refractory Hypertensionmentioning
confidence: 99%
“…It soon became apparent that far better blood pressure control was needed to “save-the-kidneys” and that more understanding of drug interactions with minoxidil and blood pressure support mechanisms might enable us to achieve better blood pressure control. These interactions extend to fascinating intra-renal mechanisms involving arteriolar hypertrophy, adrenergic receptors, renin-angiotensin and the increasingly recognized cause of reversible renal failure from drugs, the Pseudo Renal Artery Stenosis Syndrome (PRASS) (6). Interestingly, mechanisms of PRASS (to be discussed) were the cause of poor kidney outcomes in the SPRINT trial in the Elderly (2) in the Strict Blood Pressure Control Group (37 events) vs Conventional (13 events) blood pressure control group.…”
Section: Introductionmentioning
confidence: 99%