Pseudo-outbreak of<i>Mycobacterium abscessus</i>Infection Caused by Laboratory Contamination

Blossom, David B.; Alelis, K. A.; Chang, Dennis; Flores, A. H.; Gill, Jason J.; Beall, David S.; Peterson, A. M.; Jensen, Bette; Noble-Wang, Judith; Williams, Margaret M.; Yakrus, Mitchell A.; Arduino, Matthew J.; Srinivasan, Arjun

doi:10.1086/524328

Cited by 27 publications

(18 citation statements)

References 19 publications

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“…specimen contamination by NTM contained in tap water used to rinse mouth before sputum collection) [18]. Similarly, laboratories may be reporting an increased number of NTM because of contamination of reagents used in processing of specimens [19]. Therefore, isolation of NTM from clinical specimens should be evaluated carefully in the light of clinical information to assess their significance.…”

Section: Discussionmentioning

confidence: 99%

Identification of non-tuberculous mycobacteria isolated from clinical specimens at a tertiary care hospital: a cross-sectional study

2013

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BackgroundNon-tuberculous mycobacteria (NTM) are opportunistic pathogens in immuno-compromised patients. They are also increasingly recognized as pathogens in immuno-competent individuals. Globally, an increase in NTM isolation is being reported with a varied geographic prevalence of different species around the world. There is lack of data on species distribution of these organisms from Pakistan. Treatment options differ according to the species isolated and its susceptibility profile. Knowledge of local species variation would help targeted therapy. This study was performed to determine frequencies of different NTM species isolated from various clinical specimens submitted at a tertiary care hospital laboratory.MethodsNTM isolated from 25955 clinical specimens over a period of two years (2010 to 2011) were included. All NTM were identified using conventional tests. Drug susceptibility testing (DST) was performed by broth microdilution and interpreted according to Clinical and Laboratory Standards Institute’s document M24-A2.ResultsA total of 104 NTM were included in the study. Of these, 76% (54/71) rapidly growing mycobacteria (RGM) and 57.6% (19/33) slow growing mycobacteria (SGM) could be further identified. Mycobacterium fortuitum (21/54) was the commonest NTM identified among RGM followed by M. mucogenicum (12/54) and M. smegmatis (11/54). Among SGM, M. avium complex (MAC) was the most frequent (14/19). Clinical significance could be assessed in a limited number (52/104) of NTM isolates and MAC appeared to be the commonest significant NTM. Three extra-pulmonary cases were found to be healthcare associated infections. DST results for RGM showed susceptibility to amikacin (100%), clarithromycin (100%, except M. fortuitum where it is not reportable), linezolid (90%) and moxifloxacin (75%). Whereas SGM were susceptible to clarithromycin (100%), linezolid (58.8%) and moxifloxacin (64.7%).ConclusionThis is the first study reporting NTM species and their clinical significance isolated from clinical specimens from Pakistan. Isolation of NTM from clinical specimens should prompt to evaluate their clinical significance.

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Section: Discussionmentioning

confidence: 99%

Identification of non-tuberculous mycobacteria isolated from clinical specimens at a tertiary care hospital: a cross-sectional study

2013

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“…To the best of our knowledge, this is the first report of a multisite pseudo-outbreak with an identified source. Other pseudo-outbreaks of bacterial infections have been described previously; however, they were limited to a single healthcare facility, and a local explanation was found [7][8][9].…”

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confidence: 70%

“…Ticks are known to transmit a large spectrum of emerging bacterial zoonotic pathogens [7] including Borrelia burgdorferi sensu lato (sl) [8], Anaplasma phagocytophilum [9], and Babesia spp. [ More recently it was shown that the prevalence of B. henselae and Borrelia burgdorferi sl DNA in the environmental I. ricinus populations sampled in different European sites was up to 40%.…”

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confidence: 99%

Nationwide pseudo-outbreak of Salmonella enterica ssp. diarizonae, France

Thiolet

Silva

Reggiani

et al. 2011

Clinical Microbiology and Infection

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“…An increased number of NTM may be reported due to contamination of specimen during collection, contamination of reagents used in specimen processing, 25,26 or contamination of medical tools. 9 Therefore, patients testing positive for NTM should be closely assessed to ascertain the clinical significance of the laboratory result.…”

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confidence: 99%

Public health relevance of non-tuberculous mycobacteria among AFB positive sputa

Desikan

Tiwari

Panwalkar

et al. 2017

GERMS

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Pseudo-outbreak ofMycobacterium abscessusInfection Caused by Laboratory Contamination

Cited by 27 publications

References 19 publications

Identification of non-tuberculous mycobacteria isolated from clinical specimens at a tertiary care hospital: a cross-sectional study

Identification of non-tuberculous mycobacteria isolated from clinical specimens at a tertiary care hospital: a cross-sectional study

Nationwide pseudo-outbreak of Salmonella enterica ssp. diarizonae, France

Public health relevance of non-tuberculous mycobacteria among AFB positive sputa

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