Pseudo-membranous colitis

Goulston, S. J. M.; McGovern, V. J.

doi:10.1136/gut.6.3.207

Cited by 120 publications

(30 citation statements)

References 8 publications

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“…But according to one study in most cases death preceded before ulceration occurred.the exudate has a specific appearance microscopically. It consists of fibrin, mucus, and variable number of leucocytes [52].…”

Section: Discussionmentioning

confidence: 99%

“…Exudates, together with the necrotic superficial parts of mucosa blend together and form a broad membrane. Capillaries of the mucosa may be a part of the fibrinoid necrosis but vasculitis is not a characteristic of this lesion [52].…”

Section: Discussionmentioning

confidence: 99%

“…The change from normal mucosa to dilated, actively secreting glandular tubules covered by a layer of exudate is characteristic for pseudo-membranous colitis [52].…”

Section: Discussionmentioning

confidence: 99%

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Pseudomemberanous Colitis following Cesarean Delivery with Adjunctive Intracolonic Vancomycin

Ahmadi¹,

Rezaee²,

Tanha³

et al. 2016

J Gynecol Res Obstet

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Journal of Gynecological Research and Obstetrics 055According to the operation report numerous adhesions were detected during surgery, many of which especially those in the uterine incision site had been released. The patient received one dose of prophylactic cefazolin after clamping of the umbilical cord. Before discharge (discharged with personal consent) she had gas passage and defecation.Three days after C/S the patient was hospitalized with a presumed ileus. At that point she seemed well and had no fever and tachycardia; the abdomen was distended; bowel sounds were normal. On palpation, tenderness in left lower quadrant without rebound was present. In chest auscultation no abnormal finding except dextrocardia was detected (Figures 1,2).Initially the patient was managed conservatively, laboratory tests and surgery consult were ordered.The patient was not allowed to take anything by mouth and it was well emphasised to her to stay mobile. Despite gas passage her abdominal distention fluctuated during the first two days of hospitalization. During this period the laboratory findings were normal, no leucocytosis was present and hemoglobin and electrolytes were normal. Just on abdominal x ray( upright and flat) hyperinflation was to be seen.After the second day, diarrhea and a 38 C fever were added to the patients' signs. The diarrhea contained greenish liquid with white cheese -like parts. The patient was not ill, the abdominal palpation revealed no change and the laboratory findings were still normal.On the third day, abdominal distention was noticeably increased and the abdomen became tenser. Emergent surgery and gastrointestinal consult were ordered and the patient was admitted to the intensive care unit. At that point potassium was as low as 2.4 IntroductionPseudomembranous colitis (PMC) is a type of colitis (and sometimes enteritis), with special pathologic and oftentimes radiologic features, which is usually associated with the overgrowth of a bacterium called Clostridium difficile. Although this condition normally occurs following antibiotic consumption, it may rarely happen in other settings such as bowel ischemia, intestinal obstruction, and intestinal surgery or chemotherapy. Moreover, gastrointestinal infections (e.g. Staphylococcus aureus) can induce a similar condition [1].A recent increase in the incidence rate and severity of clostridium difficile infection has been reported, which is thought to be due to the great use of broad spectrum antibiotics worldwide and the development of a hypervirulant strain of this organism [2][3][4]. The presentation of PMC can vary from a self-limiting diarrhea to toxic megacolon and death [5]. Yet, many cases have confusing clinical features and their condition may not be diagnosed immediately [1]. History of previous antibiotic intake especially cephalosporins and flouroquinolones is the most important risk factor for PMC [6][7][8]. This risk is at its peak within the first month after antibiotic use [9].Immediate diagnosis and treatment of this condition can decre...

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Pseudomemberanous Colitis following Cesarean Delivery with Adjunctive Intracolonic Vancomycin

Ahmadi¹,

Rezaee²,

Tanha³

et al. 2016

J Gynecol Res Obstet

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show abstract

“…Furthermore, capillary thrombosis with vasculitis has been described in rectal biopsies of other cases of clindamycinassociated colitis (Butsch et al, 1975 Sumner and Tedesco (1975) and also the series of Goulston and McGovern (1965). A cause of the discrepancy might be the interpretation of the eosinophilic exudate and the dilated capillaries seen just beneath the surface epithelium.…”

mentioning

confidence: 97%

Crohn’s disease

2006

Biopsy Pathology in Colorectal Disease, 2Ed

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“…The early picture is characteristic with the 'volcanic eruption', a pseudomembrane con taining mucus and pus attached to a small area of necrotic surface epithelium [19][20][21]. It is not specific and can occasionally be seen in UC and Crohn's colitis.…”

Section: Rectal Biopsymentioning

confidence: 99%

Rectal Biopsy Diagnosis of Inflammatory Bowel Disease

Surawicz¹

1984

Dig Dis

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Pseudo-membranous colitis

Cited by 120 publications

References 8 publications

Pseudomemberanous Colitis following Cesarean Delivery with Adjunctive Intracolonic Vancomycin

Pseudomemberanous Colitis following Cesarean Delivery with Adjunctive Intracolonic Vancomycin

Crohn’s disease

Rectal Biopsy Diagnosis of Inflammatory Bowel Disease

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