Pseudo-Gaucher cells in peritoneal fluid: An uncommon manifestation of extramedullary hematopoiesis

Atypical Presentation of a Case of Hemoglobin E Trait with Gaucher’s Disease

“…However other authors concluded on immunoelectrophoresis and electron microscopy, that the Pseudo-Gaucher cells even in a case of myeloma were marrow macrophages engorged with immunoglobulin [7] . While most described these cells in the bone marrow , a few reports document them at other locations like peritoneal fluid [8] , spleen [9], [10] and lymphnode [11], [12] . In our patient the presence of sheets of Gaucher cells in the bone marrow biopsy specimen, focal collection of PAS positive & diastase resistant Gaucher cells in liver biopsy specimen , a reduced beta glucosidase activity in leukocytes and a significant increase in plasma chitotriosidase [13] clinched the diagnosis of Gaucher disease Type I in association with HbE trait.…”

Synchronous presentation of Gaucher disease and solitary plasmacytoma with progression to multiple myeloma

“…12 Although electron microscopy confirmed that samples from this patient contained genuine Gaucher cells, abnormal macrophages can mimic Gaucher cells. These are called pseudo-Gaucher cells and can be present in many circumstances including chronic myeloid leukaemia, 13 myelodysplasia, 14 extramedullary haematopoiesis, 15 thalassaemia, 16 Hodgkin's disease, 17 acute lymphoblastic leukaemia 18 and many others. These pseudo-Gaucher cells differ in their ultrastructural appearance, displaying a fibrillary pattern instead of the typical tubular inclusions.…”