Pseudo‐decidual reaction to Mirena coil in a cervical smear: a potential diagnostic pitfall for false‐positive cervical cytology

Hughes, C.; Woods, Joan; Turner, Leslie M.; Gourichon, David

doi:10.1111/j.1365-2303.2005.00247.x

Cited by 2 publications

(2 citation statements)

References 3 publications

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“…Considering the results of the abovementioned studies as well as our results, LNG-IUS should not be considered to have a genotoxic effect. However, Hughes et al reported cytological findings in the cervical smear of a 54-year-old Caucasian woman that was evaluated two years afterLNG-IUS placement (Hughes et al 2005). The authorsstated that the nuclear chromatin was finely granular with occasional nuclear irregularity, and the nuclei contained one or more prominent nucleoli.…”

Section: Discussionmentioning

confidence: 99%

Genotoxicity evaluation of levonorgestrel-releasing intrauterine system (LNG-IUS) in exfoliated cervical cells using the micronucleus (MN) test

Zamani

Karataylı

Gezginç

et al. 2021

Preprint

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Purpose: This study aimed to determine whether any relationships exist between the levonorgestrel-releasing intrauterine system (LNG-IUS) and micronuclei or other nuclear anomalies, including condensed chromatin, karyorrhexis, and karyolysis, on the cervical epithelium in young women. Methods: A prospective observational study was conducted. The study population comprised healthy women aged ≤40 years who were referred for birth control. Cervical smears that were obtained from 18 women before and three months after LNG-IUS insertion were tested for micronuclei and other nuclear anomaliesusing the micronucleus test. Results: The results revealed no statistically significant difference (P>0.05) in the frequency of micronucleated exfoliated cervical mucosa cells after LNG-IUS exposure. However, LNG-IUS was able to increase other nuclear alterations closely related to cytotoxicity. Conclusions: Data indicated that exposure to LNG-IUS may not be a factor in inducing chromosomal damage, but it can promote cytotoxicity.

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Section: Discussionmentioning

confidence: 99%

Genotoxicity evaluation of levonorgestrel-releasing intrauterine system (LNG-IUS) in exfoliated cervical cells using the micronucleus (MN) test

Zamani

Karataylı

Gezginç

et al. 2021

Preprint

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show abstract

“…3,4 Pseudodecidualisation of endometrial stroma has been reported in a ThinPrep sample. 5 The material could therefore represent cytolytic endometrium, which could be misinterpreted as tumour diathesis, particularly if there are also IUCD cells or 'Dings' present in the sample. These are single endometrial cells with vacuolated cytoplasm, a high nuclear-cytoplasmic ratio, and large hyperchromatic nuclei with smudged chromatin, which may mimic severe squamous dysplasia, especially if an adequate clinical history is lacking.…”

mentioning

confidence: 99%

Dense deposits in cervical cytology samples of patients fitted with intrauterine contraceptive devices

Thiryayi

Rana

Wadehra

2009

Diagnostic Cytopathology

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Pseudo‐decidual reaction to Mirena coil in a cervical smear: a potential diagnostic pitfall for false‐positive cervical cytology

Cited by 2 publications

References 3 publications

Genotoxicity evaluation of levonorgestrel-releasing intrauterine system (LNG-IUS) in exfoliated cervical cells using the micronucleus (MN) test

Genotoxicity evaluation of levonorgestrel-releasing intrauterine system (LNG-IUS) in exfoliated cervical cells using the micronucleus (MN) test

Dense deposits in cervical cytology samples of patients fitted with intrauterine contraceptive devices

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