Pseudo Chediak-Higashi anomaly in blasts from acute lymphoblastic leukemia

ultrastrutal investigation on Pseudo Chediak–Higashi abnormality in acute lymphoblastic leukemia: A case report

“…Pseudo-Chediak-Higashi (PCH) anomaly is seen in various types of leukemia,including acute monoblastic leukemia(AML-M 5 ) 1 ,mixed phenotype acute leukemia 2 ,acute myeloid leukemia 3,4 ,chronic myeloid leukemia(CML) 5 , and myelodysplastic syndrome(MDS) 6 .PCH is characterized by the appearance of eosinophilic granules of different sizes in cytoplasm of abnormal leukocytes when examined by light microscope. The disease shares similarities in appearance with the granules noted in Chediak-Higashi syndrome(CHS).In some rare cases, intracytoplasmic vacuoles are positive for myeloperoxidase(MPO) and periodic acid-Schiff (PAS) around the myeloblasts, which probably result from the accumulation of metabolic waste or damaged organelles 3 .Although there are some reports on the abnormality of cells in acute lymphoblastic leukemia(ALL) [7][8][9] ,the abnormal granules have been rarely interpreted. Herein, we report a rare case of ALL in a young patient because of rare morphology.…”

Ultrastructural investigation on pseudo Chediak–Higashi abnormality in acute lymphoblastic leukemia: A case report

“…In some rare cases, intracytoplasmic granules are positive for myeloperoxidase (MPO) and periodic acid-Schiff (PAS) around the myeloblasts, which probably result from the accumulation of metabolic waste or damaged organelles. 3 Although there are some reports on the abnormality of cells in ALL, [7][8][9] the abnormal granules have been rarely interpreted. Herein, we report a case of ALL in a young patient because of rare morphology.…”

“…The PCH granules are found in many types of cells, including immature myeloid cells, lymphocytes, and monocytes. Gavillet et al 9 reported an elderly patient with the presence of PCH granules after relapse of B-ALL. In our study, we first found a novel morphological entity of lymphoblastic cells through TEM.…”