Pseudo-branched polyester copolymer: an efficient drug delivery system to treat cancer

Abstract

New aliphatic pseudo-branched polyester copolymers are synthesized from diethylmalonate. The formulated nanomedicine successfully encapsulates therapeutic drug in higher dosage and deliver specifically to cancer cells for diagnosis and treatment.

Emerging Trends of Nanomedicines in the Management of Prostate Cancer: Perspectives and Potential Applications

“…Pseudo-branched polymers are spherical and employ the solvent diffusion approach to water-dispersible polymeric nanoparticles, delivering therapeutic doxorubicin (DOX) medication. They target PSMA receptor upregulation of LNCaP prostate cancer cells [ 86 ].…”

Core-Tunable Dendritic Polymer: A Folate-Guided Theranostic Nanoplatform for Drug Delivery Applications

“…This parent HBPE polymer was used to formulate nanomedicines for the delivery of paclitaxel to tumor cells. Next, the polarity of HBPE polymers’ cavities was tuned by copolymerizing the A 2 B monomer with trigol, which facilitated the delivery of a more hydrophilic drug, doxorubicin hydrochloride, to prostate cancer cells . These results indicated the importance of our parent HBPE polymers’ unique design and potential to foster research and development.…”

Branched Poly(ε-caprolactone)-Based Copolyesters of Different Architectures and Their Use in the Preparation of Anticancer Drug-Loaded Nanoparticles

“…Consequently, the prepared nanoDDS must successfully encapsulate anticancer medicines (which, in most cases, are administrated in extremely low doses), be easily converted into a stable NP colloidal dispersion within the body, and simultaneously be stable during storage. In this context, although linear biodegradable polymers, such as polyacrylic acid (PAA), poly(lactic acid) (PLA), and poly(lactide-glycolide) (PLGA), have been extensively employed in the last few decades, they exhibit several limitations associated with their high polydispersity, low solubility, and coil-like morphology [ 15 , 16 , 17 , 18 , 19 ]. These limitations, which lead to low surface functionality and low encapsulation efficiency, have restricted their use in such nanoDDSs, turning, consequently, the focus of several pharmaceutical formulations and material scientists into the synthesis of new polymeric compounds [ 20 , 21 , 22 , 23 ].…”

“…In this vein, an appealing approach to overcome the aforementioned limitations of linear polymeric materials is to use branched (or hyperbranched) analogs [ 15 ]. In general, branched polymers (or copolymers) represent an attractive alternative to other similarly branched structures, such as branched polymeric micelles, comb-like compounds, and dendrimers [ 24 , 25 , 26 , 27 , 28 , 29 , 30 ].…”

“…In general, branched polymers (or copolymers) represent an attractive alternative to other similarly branched structures, such as branched polymeric micelles, comb-like compounds, and dendrimers [ 24 , 25 , 26 , 27 , 28 , 29 , 30 ]. Especially in the case of dendrimers (which provide a vast surface with functional groups that can be utilized as active sites to bind target molecules via chemical bonding, enabling them to efficiently deliver a wide variety of drugs), the use of branched polymers as alternatives can overcome the laborious multi-step synthesis and, consequently, the high manufacturing cost, while maintaining their significant advantages (such as three-dimensional globular structure, high polymeric cavities, high solubility, and high surface functionality) [ 15 , 31 ]. Moreover, when these new branched polymeric materials are based on polyesters, several additional advantages are also added, such as high aqueous stability, excellent biocompatibility, and easily tunable hydration and biodegradation characteristics [ 15 ].…”