Abstract:Background and purpose
Previous studies have reported conflicting results regarding possible anticipation in familial E200K Creutzfeldt–Jakob disease (fCJD). Our objective was to use a large database to assess the age of disease onset (AODO) in CJD.
Methods
The study population included 477 CJD patients [266 with fCJD, 145 with sporadic CJD (sCJD) and 66 patients of Libyan origin but negative family history] from the Israeli registry of CJD conducted since 1954. In all patients, AODO in relatives and family tr… Show more
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