PSC-db: A Structured and Searchable 3D-Database for Plant Secondary Compounds

Valdés-Jiménez, Alejandro; Peña-Varas, Carlos; Borrego-Muñoz, Paola; Arrué, Lily; Alegría-Arcos, Melissa; Nour-Eldin, Hussam Hassan; Drèyer, Ingo; Núñez-Vivanco, Gabriel; Ramírez, David

doi:10.3390/molecules26041124

Cited by 12 publications

(5 citation statements)

References 42 publications

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“…One of the most prominent features of plant biochemistry, which is almost completely absent in the animal kingdom, is the ability of plants to synthesize a broad spectrum of small organic molecules of multiple different structures, which are collectively known as plant secondary metabolites [ 23 ]. More than 200,000 different members of this group are currently known [ 24 ]. Secondary metabolites carry out a variety of functions, which include protection from ultraviolet radiation, regulation of physiological processes, resistance to physical stress, and interaction with different organisms, such as herbivorous animals or parasitic fungi [ 25 ].…”

Section: Structure and Properties Of Plant Polyphenolsmentioning

confidence: 99%

Inhibition of Cancer Development by Natural Plant Polyphenols: Molecular Mechanisms

Lyubitelev

Studitsky

2023

IJMS

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Malignant tumors remain one of the main sources of morbidity and mortality around the world. A chemotherapeutic approach to cancer treatment poses a multitude of challenges, primarily due to the low selectivity and genotoxicity of the majority of chemotherapeutic drugs currently used in the clinical practice, often leading to treatment-induced tumors formation. Highly selective antitumor drugs can largely resolve this issue, but their high selectivity leads to significant drawbacks due to the intrinsic tumor heterogeneity. In contrast, plant polyphenols can simultaneously affect many processes that are involved in the acquiring and maintaining of hallmark properties of malignant cells, and their toxic dose is typically much higher than the therapeutic one. In the present work we describe the mechanisms of the action of polyphenols on cancer cells, including their effects on genetic and epigenetic instability, tumor-promoting inflammation, and altered microbiota.

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Section: Structure and Properties Of Plant Polyphenolsmentioning

confidence: 99%

Inhibition of Cancer Development by Natural Plant Polyphenols: Molecular Mechanisms

Lyubitelev

Studitsky

2023

IJMS

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“…На сегодняшний день обнаружены более 200 тыс. представителей этой обширной группы соединений [11] излучения, регуляция физиологических процессов, обеспечение устойчивости к физическим воздействиям и различных способов взаимодействия с животными [12].…”

Section: строение и свойства растительных полифеноловunclassified

Mechanisms of action of plant polyphenols on the initiation of carcinogenesis

et al. 2023

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Genetic apparatus of human cells is constantly affected by a broad spectrum of mutagenic factors, both exogenous and endogenous. Genetic and epigenetic disorders, which emerge as a result of this influence, become the main cause of the majority of malignant neoplasias. Several different approaches were proposed to prevent these disorders, including the suppression of the activity of mutagenic factors by treatment with certain chemical compounds. Plant polyphenols are promising candidates for the development of chemopreventive drugs, as they exert the ability to regulate the metabolic activation of procarcinogens and modulate the cellular oxidative stress. In the present review, classification of plant phenolic compounds and their interactions with biological macromolecules are described, along with the molecular mechanisms of their influence on the enzymes and regulatory pathways of phase I xenobiotic metabolism, and the prevention of oxidative stress. Interactions between natural polyphenols and patient’s microbiota is also described.

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“…The different processes of biopesticide design are illustrated in Figure 3. The 3D structure of required binding molecules can be obtained using special databases such as PubChem and ChEMBL [69,70].…”

Section: In Silico Approachmentioning

confidence: 99%

Plant-Derived Protectants in Combating Soil-Borne Fungal Infections in Tomato and Chilli

Arora

Sharma

Poczai

et al. 2022

JoF

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Fungal infections transmitted through the soil continue to pose a threat to a variety of horticultural and agricultural products, including tomato and chilli. The indiscriminate use of synthetic pesticides has resulted in a slew of unintended consequences for the surrounding ecosystem. To achieve sustainable productivity, experts have turned their attention to natural alternatives. Due to their biodegradability, varied mode of action, and minimal toxicity to non-target organisms, plant-derived protectants (PDPs) are being hailed as a superior replacement for plant pesticides. This review outlines PDPs’ critical functions (including formulations) in regulating soil-borne fungal diseases, keeping tomato and chilli pathogens in the spotlight. An in-depth examination of the impact of PDPs on pathogen activity will be a priority. Additionally, this review emphasises the advantages of the in silico approach over conventional approaches for screening plants’ secondary metabolites with target-specific fungicidal activity. Despite the recent advances in our understanding of the fungicidal capabilities of various PDPs, it is taking much longer for that information to be applied to commercially available pesticides. The restrictions to solving this issue can be lifted by breakthroughs in formulation technology, governmental support, and a willingness to pursue green alternatives among farmers and industries.

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PSC-db: A Structured and Searchable 3D-Database for Plant Secondary Compounds

Cited by 12 publications

References 42 publications

Inhibition of Cancer Development by Natural Plant Polyphenols: Molecular Mechanisms

Inhibition of Cancer Development by Natural Plant Polyphenols: Molecular Mechanisms

Mechanisms of action of plant polyphenols on the initiation of carcinogenesis

Plant-Derived Protectants in Combating Soil-Borne Fungal Infections in Tomato and Chilli

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