Psathyrella candolleana and Agaricus bisporus Extracts Provide Protection against DNA Oxidative Damage Induced by Doxorubicin

Al-Habib, Mouthana N; Holliday, J. F.; Aladahmy, Mohammad S

doi:10.1615/intjmedmushrooms.2018027002

Cited by 10 publications

(6 citation statements)

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“…Aqueous or organic extracts of mushrooms of various origins or their isolated ingredients were shown to have genoprotective properties against the insult of genotoxic and mutagenic carcinogens both in vitro (4)(5)(6)(7)(8) and in vivo (9). In a recent study, Chaga mushroom (Inonotus obliquus) polysaccharides exhibited genoprotective effects in UVBexposed embryonic zebrafish (Danio rerio) through altered expression of DNA repair genes (10).…”

Section: Introductionmentioning

confidence: 99%

Genoprotective activity of the Pleurotus eryngii mushrooms following their in vitro and in vivo fermentation by fecal microbiota

et al. 2022

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Pleurotus eryngii mushrooms are commercially cultivated and widely consumed due to their organoleptic properties, and the low caloric and high nutritional value. In addition, they contain various biologically active and health-promoting compounds; very recently, their genoprotective effect in Caco-2 cells after their fermentation by the human fecal microbiota was also documented. In the current study, the effect of P. eryngii pre- and post-fermentation supernatants in micronuclei formation was evaluated in human lymphocytes. In addition, the genoprotective properties of increasing concentrations of aqueous extracts from P. eryngii mushrooms (150, 300, 600 mg/kg) against the cyclophosphamide-induced DNA damage were studied in young and elderly female and male mice in bone marrow and whole blood cells. The ability of the highest dose (600 mg/kg) to regulate the main cellular signaling pathways was also evaluated in gut and liver tissues of female animals by quantifying the mRNA expression of NrF2, Nfkβ, DNMT1, and IL-22 genes. P. eryngii post-fermentation, but not pre-fermentation, supernatants were able to protect human lymphocytes from the mitomycin C-induced DNA damage in a dose-dependent manner. Similarly, genoprotection was also observed in bone marrow cells of mice treated by gavage with P. eryngii extract. The effect was observed in all the experimental groups of mice (young and elderly, male and female) and was more potent in young female mice. Overexpression of all genes examined was observed in both tissues, mainly among the elderly animals. In conclusion, P. eryngii mushrooms were shown to maintain genome integrity through protecting cells from genotoxic insults. These beneficial effects can be attributed to their antioxidant and immunomodulatory properties, as well as their ability to regulate the cell’s epigenetic mechanisms and maintain cell homeostasis.

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Section: Introductionmentioning

confidence: 99%

Genoprotective activity of the Pleurotus eryngii mushrooms following their in vitro and in vivo fermentation by fecal microbiota

et al. 2022

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“…It has a wide distribution on lawns or pastures in Europe and North America. Previous pharmacological studies indicated that the extracts of P. candolleana showed a marked anticlastogenic effect against DNA damage [1][2][3], while chemical investigations on this fungus have demonstrated guanacastane-type diterpenoids [4,5], which possess a unique 5/7/6 tricyclic backbone that have been found only in several fungal species. These diterpenoids have been detected to possess antibacterial and cytotoxic properties [5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Psathyrellins A–E, Antibacterial Guanacastane Diterpenoids from Mushroom Psathyrella candolleana

Yang

et al. 2021

Nat. Prod. Bioprospect.

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Five previously undescribed guanacastane diterpenoids, namely psathyrellins A–E (1–5), were obtained from cultures of the mushroom Psathyrella candolleana. Their structures with absolute configurations were elucidated by extensive spectroscopic methods. Compounds 1–3 showed antibacterial activity against four strains with MIC values in a range of 16–128 μg/mL. Graphic Abstract

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“…14,15 In Iraq, its extract was used as a medicine to protect against DNA oxidative damage induced by doxorubicin. 16,17 Our previous chemical investigations on the fermentation broth of P. candolleana produced a series of guanacastane-type diterpenoids. 14 One of the guanacastane derivative, psathyrelloic acid, showed good antibacterial activity against Staphylococcus aureus.…”

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confidence: 99%

“…The basidiomycete Psathyrella candolleana , a mushroom in the family Psathyrellaceae, is commonly found on lawns or pastures in Europe and North America. It is also widely distributed in Yunnan and Sichuan Provinces of China. , In Iraq, its extract was used as a medicine to protect against DNA oxidative damage induced by doxorubicin. , Our previous chemical investigations on the fermentation broth of P. candolleana produced a series of guanacastane-type diterpenoids . One of the guanacastane derivative, psathyrelloic acid, showed good antibacterial activity against Staphylococcus aureus .…”

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confidence: 99%

Psathyrins: Antibacterial Diterpenoids from Psathyrella candolleana

et al. 2020

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Two skeletally novel tetracyclic diterpenoids, psathyrins A (1) and B (2), have been characterized from cultures of the basidiomycete Psathyrella candolleana. Their structures including absolute configurations were established by means of spectroscopic methods, as well as ECD calculations. They possess a novel 5/5/4/6-fuesd ring system, for which the biosynthetic pathway is proposed. Compounds 1 and 2 inhibited the growth of Staphylococcus aureus and Salmonella enterica.

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Psathyrella candolleana and Agaricus bisporus Extracts Provide Protection against DNA Oxidative Damage Induced by Doxorubicin

Cited by 10 publications

References 0 publications

Genoprotective activity of the Pleurotus eryngii mushrooms following their in vitro and in vivo fermentation by fecal microbiota

Genoprotective activity of the Pleurotus eryngii mushrooms following their in vitro and in vivo fermentation by fecal microbiota

Psathyrellins A–E, Antibacterial Guanacastane Diterpenoids from Mushroom Psathyrella candolleana

Psathyrins: Antibacterial Diterpenoids from Psathyrella candolleana

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