Psammoma bodies in serous carcinoma of the ovary

Aure, J. Chr.; Høeg, Kari; Kolstad, Per

doi:10.1016/0002-9378(71)90844-1

Cited by 41 publications

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“…(8)(9)(10)(11)(12) Of ovarian tumors, the serous type is often associated with concentric rings of calcification known as psammoma bodies. (13,14) Psammoma bodies are most characteristic of serous carcinomas, (15,16) but are frequently found in benign and borderline tumors and non-neoplastic serous epithelial proliferations. (14,17) In 1990, Gilks et al outlined morphological criteria for the diagnosis of a ''psammocarcinoma'' for serous carcinomas containing numerous psammoma bodies.…”

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“…( 14,18–20 ) However, the prognostic importance of psammoma bodies is still controversial. Some authors have suggested that tumors with psammoma bodies showed a better prognosis than those without them, ( 15,21 ) whereas others believe that the occurrence of psammoma bodies is of no prognostic significance. ( 16 ) Moreover, the etiology of psammoma body formation is not well established; however, several hypotheses pertaining to the origin and development of psammoma bodies have been proposed, including apoptosis of tumor cells ( 22–24 ) and osteoinductive cytokines produced by macrophages.…”

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Long‐term oncological outcomes of ovarian serous carcinomas with psammoma bodies: A novel insight into the molecular pathogenesis of ovarian epithelial carcinoma

Motohara

Tashiro²,

Miyahara

et al. 2010

Cancer Science

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A two-tier system in which ovarian epithelial carcinomas are subdivided into type I and type II tumors has been proposed on the basis of recent molecular pathogenesis findings. Type I tumors, unrelated to tumor protein p53 (TP53) mutations, show favorable prognosis in a slow step-wise process, whereas type II tumors, related to TP53 mutations, contribute to poor prognosis. Ovarian serous carcinomas with excessive psammoma bodies behave like type I tumors. However, their etiology and prognostic significance remain obscure. The objective of the present study was to evaluate the characteristic features and potential relevance of psammoma bodies to the clinical outcome of 44 patients with serous carcinomas with long-term follow-up. The 5-and 10-year survival rates were significantly different between the serous carcinomas with less than 5% area of psammoma bodies and those at least 5% area (P < 0.01). All tumors with at least 5% area were both diploid and immunohistochemically negative for TP53 mutations. All patients with these tumors, including eight with International Federation of Gynecology and Obstetrics (FIGO) stages III or IV disease, survived more than 5 years and their 10-year survival rate was 76%. In multivariate analysis using clinical parameters, the apparent existence of psammoma bodies was an indication to view serous carcinomas as type I tumors with long-term survival. Our results suggested that the formation of psammoma bodies is associated with increased apoptotic tumor cell death related to normal TP53 function. The pathological findings of psammoma bodies might contribute to the consideration of pathogenesis and to the development of prognostic prediction rules for serous carcinomas. (Cancer Sci 2010; 101: 1550-1556 O varian carcinoma is the fifth leading cause of cancerrelated death and the most lethal malignancy of the female reproductive tract.(1) The clinical outcome of patients with advanced ovarian carcinoma is poor despite aggressive surgery and intensive chemotherapy. Accurate evaluation of the primary tumor is important to determine the prognosis and treatment strategies. Various known prognostic factors such as clinical stage of disease, histological grade, and DNA ploidy have been established in an effort to estimate a patient's individual prognosis and to improve therapeutic strategies in ovarian carcinoma. (2)(3)(4)(5) Shih and Kurman recently proposed a model of ovarian carcinogenesis based on clinical, pathological, and molecular genetic studies.(6) The model divides ovarian carcinomas into two groups designated type I and type II. Type I tumors show favorable prognosis and generally develop from wellestablished precursor lesions or borderline tumors. Type I tumors, including micropapillary serous carcinoma (7) and well-differentiated serous carcinoma, are genetically stable and are characterized by mutations in a number of different genes including v-Ki-ras2 kirsten rat sarcoma viral oncogene homolog (KRAS), v-raf murine sarcoma viral oncogene homolog B1 (BRAF), and v-erb-b2 ery...

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Long‐term oncological outcomes of ovarian serous carcinomas with psammoma bodies: A novel insight into the molecular pathogenesis of ovarian epithelial carcinoma

Motohara

Tashiro²,

Miyahara

et al. 2010

Cancer Science

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“…We believe that it is the unique ultrasonic feature of the large amount of sand in the shaft axis of papillary bers pathologically. Some researchers believed that the presence of tumor sand bodies meant that they had good biological behavior and prognosis [12] .The presence of sand bodies could block the growth of tumor cells and even formed a barrier for tumor metastasis [13] .…”

Section: Discussionmentioning

confidence: 99%

The Diagnostic Value of Multi-Modal Ultrasound on the Ovarian Serous Surface Papillary Borderline Tumor

Xie¹,

Liu²,

Chen³

et al. 2021

Preprint

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Background: Compared with epithelial ovarian cancer, borderline ovarian tumor has earlier onset age and better prognosis. Ovarian serous surface papillary borderline tumor (SSPBT) is a special subtype of ovarian serous borderline tumor, which is rare in clinic. It is easy to be misdiagnosed as malignant before operation. SSPBT usually occurs in women of childbearing age. The operation of preserving fertility can have a higher pregnancy rate. Therefore, preoperative ultrasound for qualitative diagnosis of SSPBT is of great significance in the selection of surgical methods and treatment. There are few reports on the imaging of SSPBT, and the multimodal ultrasound features of SSPBT combined with conventional ultrasound, two-dimensional and three-dimensional contrast-enhanced ultrasound have not been reported. The purpose of this article is to explore the multimodal ultrasonic characteristics of ovarian SSPBT, combining its clinical and pathological features.Result: The conventional ultrasound of ovarian SSPBT was characterized by large patchy substantial masses wrapped around the ovary.Large flaky dense fine anechoic areas could be seen in the parenchyma,accompanied by speckle strong echo with different degrees.Peritoneal implants were observed in 3 cases(60%)and ascites were found in 4 cases(80%).On further contrast-enhanced ultrasonography,with reference to the myometrium,the tumor on 2D-CEUS showed synchronous or delayed eccentric and inhomogeneous enhancement,and subsided earlier than the uterine wall.The tortuously running tumor trophoblast vessels from the periovarian of the affected side could be further observed clearly and stereospecially on 3D-CEUS.Angiographic rising time(RT),time to peak(TTP),peak intensity(PI),area under the curve(AUC)and half time of descending peak intensity(HT)were significantly different from those of the myometrium(P<0.05).The speckled strong echo observed by conventional ultrasound was correlated with the sand body of the fiber stalk axis in the papillary structure under pathological microscope,while the tortuosity and dilation of microvessels in the fibrous connective tissue axis was the pathological basis of their CEUS perfusion.Conclusion: There are characteristic manifestations of ovarian SSPBT on multimodal ultrasound,which are closely related to the pathological structure.Multimodal ultrasound has important reference value in the diagnosis of ovarian SSPBT.

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“…1,2 On the other hand, it has been reported that the presence and extent of sand grains do not correlate with prognosis. 4,5 On imaging examination, although CT scan exhibits a large amount of calcification in the ovarian tumor, it is very difficult to rule it out from other benign calcified diseases such as calcified leiomyoma, Brenner tumor, and fibrothecoma. On the other hand, there is a report that FDG PET/CT may be useful in differentiating malignancy.…”

Section: Discussionmentioning

confidence: 99%

Primary ovarian serous psammocarcinoma-a case report with mini literature review

Baba¹,

Fukagawa²,

Itamochi³

et al. 2020

OGIJ

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Serous psammocarcinoma is a rare subtype of serous carcinoma in which a significant number of psammoma bodies are present histologically. Because it is an extremely rare disease, the pathogenesis of the disease remains unclear. Here we present a case of primary ovarian serous psammocarcinoma in which computed tomography (CT) imaging of the abdomen was useful for the diagnosis. A female patient was referred to our department with a complaint of abdominal distention. Pelvic magnetic resonance imaging revealed a multifocal tumor with a papillary enhancement in the right appendicular region, and abdominal CT imaging exhibited marked calcification of the enhancement. She underwent a laparotomy for suspected right ovarian cancer. As postoperative pathological examination revealed dominant stromal infiltration of psammoma bodies beneath peritoneum, this case was diagnosed as primary ovarian serous psammocarcinoma at FIGO Stage IIB. The patient was treated with six courses of paclitaxel plus carboplat in after the surgery. She is currently under outpatient observation without any signs of recurrence after 8 years of treatment. The case of significant calcification of the intra cystic enrichment on CT imaging is considered to be a case of this disease.

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Psammoma bodies in serous carcinoma of the ovary

Cited by 41 publications

References 0 publications

Long‐term oncological outcomes of ovarian serous carcinomas with psammoma bodies: A novel insight into the molecular pathogenesis of ovarian epithelial carcinoma

Long‐term oncological outcomes of ovarian serous carcinomas with psammoma bodies: A novel insight into the molecular pathogenesis of ovarian epithelial carcinoma

The Diagnostic Value of Multi-Modal Ultrasound on the Ovarian Serous Surface Papillary Borderline Tumor

Primary ovarian serous psammocarcinoma-a case report with mini literature review

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