Psammocarcinoma of ovary with serous cystadenofibroma of contralateral ovary: a case report

Jain, Deepali; Akhila, L; Kawatra, Vibha; Aggarwal, Pallavi; Khurana, Nita

doi:10.1186/1752-1947-3-9330

Cited by 10 publications

(10 citation statements)

References 17 publications

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“…Clinically, patients usually present with abdominal discomfort and increase in abdominal girth. These tumors are usually unilateral, but rarely may these be bilateral as in our case [ 11 ]. CA-125 levels are commonly elevated [ 12 ].…”

Section: Discussionmentioning

confidence: 93%

Bilateral Serous Psammocarcinoma of Ovary: Rare Variant Low Grade Serous Carcinoma

Jena

Mishra

Mohapatra

et al. 2015

Case Reports in Obstetrics and Gynecology

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Serous psammocarcinoma is a rare variant of serous carcinoma arising from either ovary or peritoneum, characterized by massive psammoma body formation, low grade cytologic features, and invasiveness. Its clinical behavior is similar to serous borderline tumors with relatively favorable prognosis. We report herein a case of a 60-year-old postmenopausal woman who presented with abdominal distension. Contrast enhanced computed tomography (CECT) revealed calcified pelvic masses with ascites. Elevated serum CA-125 (970 U/mL) suggested malignant ovarian neoplasm. Patient underwent exploratory laparotomy with primary debulking surgery. Histopathology showed bilateral serous psammocarcinoma of ovary with invasive implants on omentum. Adjuvant chemotherapy was advised in view of advanced stage disease, although its benefits are poorly defined due to rarity of the tumor. However, patient opted out of it and is now on follow-up.

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Section: Discussionmentioning

confidence: 93%

Bilateral Serous Psammocarcinoma of Ovary: Rare Variant Low Grade Serous Carcinoma

Jena

Mishra

Mohapatra

et al. 2015

Case Reports in Obstetrics and Gynecology

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“…They are reported to result from dystrophic calcification, from calcium accumulation in degenerated or necrotic cells, or from collagen calcification. They are also likely to represent a biologic process which leads to degeneration of cancer cells, with consequent death and delay of tumor growth (14,19,21,22). This last proposition suggests that their formation is the cause of the indolent character they provide to neoplastic cells.…”

Section: Literature Review and Discussionmentioning

confidence: 99%

“…More investigation is required to elucidate their exact nature, their formation mechanism, and whether they are the result or the cause of retardation of tumor growth in ovarian cancer. Although the exact mechanism of psammoma body formation is yet unclear, they are known to be associated with increased apoptotic cell death, BRAF mutation, and normal TP53 function, all of which are more profound in low-grade ovarian serous adenocarcinoma (22,23,24). FDG uptake can occur through inflammatory processes secondary to these mechanisms.…”

Section: Literature Review and Discussionmentioning

confidence: 99%

“…There are two distinct entities with regard to the deposition of psammomas in different carcinomas, carcinomas with psammoma bodies and psammocarcinomas. The later arise from the ovaries or peritoneum, and certain criteria must be fulfilled in order to characterize a carcinoma with psammoma bodies as psammocarcinomas (22). Cases reported in the literature include primary psammocarcinomas of the ovary or peritoneum, or psammoma deposits in benign and malignant conditions such as serous adenocarcinoma of the ovaries, thyroid, meningioma, pancreas and calcifications in metastatic lesions (3,6,14,15,16,20,21,22,25,26).…”

Section: Literature Review and Discussionmentioning

confidence: 99%

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Hypermetabolic Calcified Lymph Nodes on 18Fludeoxyglucose-Positron Emission Tomography/Computed Tomography in a Case of Treated Ovarian Cancer Recurrence: Residual Disease or Benign Formation?

Nikaki

Alexopoulos²,

Vlachou³

et al. 2016

Mirt

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The contribution of positron emission tomography/computed tomography (PET/CT) with 18F-fludeoxyglucose (FDG) in evaluating ovarian cancer recurrence even after a prolonged disease-free interval, and in therapy response is well-described. Calcifications observed in CT, although usually attributed to benign conditions, may actually represent active disease. Such an example of calcified formations is psammoma bodies. We present a case of 56-y. o. patient with ovarian cancer relapse at the supraclavicular area 18 years after complete response and disease-free interval. The patient received chemotherapy and underwent 18F-FDG-PET/CT for the evaluation of treatment response. Both CT corrected and uncorrected PET images showed hypermetabolism in the massively calcified lymph nodes in the neck, mediastinum, axilla and abdomen, indicative of active residual disease.

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“…Jain et al [2] reviewed 29 cases of ovarian origin. Sanguedolce et al [3], Riboni et al [4], and Zakkouri et al [5] have since added 3 more cases of ovarian psammocarcinoma.…”

Section: Introductionmentioning

confidence: 99%

Enormous Cystic Tumor of Peritoneal Psammocarcinoma Exhibiting Complete Response to Cisplatin and Cyclophosphamide after Suboptimal Cytoreduction: Case Report and Review of the Literature

Takahashi¹,

Ueda²,

Shioji³

et al. 2012

Gynecol Obstet Invest

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Psammocarcinoma is a serous peritoneal tumor arising from the ovary or the peritoneum and characterized by low-grade nuclear features, extensive psammoma bodies, and invasiveness. Only 62 cases have ever been documented, 30 primary peritoneal and 32 primary ovarian, most of which presented as small tumors. Adjuvant therapies, including chemotherapy and radiation, were performed in 12 of the primary peritoneal cases, without any clear evidence of benefit. We present a case of an unusually large primary peritoneal psammocarcinoma with unexpected outcome. The patient was a 38-year-old woman with a tumor of the peritoneum which adhered densely to the uterus and rectum and developed into the intra-abdominal cavity and retroperitoneal space. After adhesiolysis of the tumor and rectum, suboptimal surgical reduction left a 4 cm × 2 cm tumor segment. Postoperative chemotherapy, consisting of paclitaxel and carboplatin (TC) for 1 course, and cyclophosphamide and cisplatin (CP) for 5 courses, was conducted. The residual tumor responded completely to the chemotherapy and the patient is alive today, with no evidence of disease 15 months after the surgery. Our case implies that CP therapy is a potential regimen of postoperative remission-induction therapy for suboptimally resected primary peritoneal psammocarcinoma.

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Psammocarcinoma of ovary with serous cystadenofibroma of contralateral ovary: a case report

Cited by 10 publications

References 17 publications

Bilateral Serous Psammocarcinoma of Ovary: Rare Variant Low Grade Serous Carcinoma

Bilateral Serous Psammocarcinoma of Ovary: Rare Variant Low Grade Serous Carcinoma

Hypermetabolic Calcified Lymph Nodes on 18Fludeoxyglucose-Positron Emission Tomography/Computed Tomography in a Case of Treated Ovarian Cancer Recurrence: Residual Disease or Benign Formation?

Enormous Cystic Tumor of Peritoneal Psammocarcinoma Exhibiting Complete Response to Cisplatin and Cyclophosphamide after Suboptimal Cytoreduction: Case Report and Review of the Literature

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