“…Compounds possessing the rare dibrominated 1,6-dioxa-2-azaspiro [4.6]undeca-2,7,9-triene moiety (spirooxepinisoxazoline) are derived from bromotyrosine and are named psammaplysins [2][3][4][5][6][7][8][9][10], ceratinamides [9,11] and ceratinadins [12]. Compounds with the spirooxepinisoxazoline moiety were reported mainly from members of the Verongiida [2][3][4][5][6][7][8][9][10]12] with only two representatives from the order Dictyoceratida [11,13]. Psammaplysins' backbone consists of two dibrominated subunits, 8,10-dibromo-4-hydroxy-9-methoxy-1,6-dioxa-2-azaspiro [4.6]undeca-2,7,9-triene-3-carboxylic acid (subunit A) and 3-(4-(2-aminoethyl)-2,6-dibromophenoxy)propan-1-amine subunit (subunit B, moloka'iamine) [14], connected together through an amidic linkage between the carboxylic moiety (C-9) of the substituted spirooxepinisoxazoline unit and the terminal amino group at C-10 of the moloka'iamine ( Figure 1) to give the first reported compound of this class, psammaplysin A, (N-(3-(4-(2-aminoethyl)-2,6-dibromophenoxy)propyl)-8,10-dibromo-4-hydroxy-9-methoxy-1,6-dioxa-2azaspiro [4.6]undeca-2,7,9-triene-3-carboxamide) [2].…”