PSA-NCAM is up-regulated during optic nerve regeneration in lizard but not in goldfish

Harman, A.M.; Rodger, Jennifer; Ahmat, Alicia; Thomas, Claire Le; Bartlett, Carole A.; Chen, P.; Dunlop, Sarah; Beazley, Lyn

doi:10.1016/s0014-4886(03)00081-5

Cited by 9 publications

(4 citation statements)

References 42 publications

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“…To examine the potential effect of MMP1 on nerve regeneration in the amputated digits of mice, the deposition of NCAM (CD56) was analyzed, which is present in peripheral nerve fibers and neuromuscular junctions [33], [34] and abundantly secreted during nerve regeneration [35], [36]. Dystrophin was co-stained to visualize the muscle cells in juxtaposition to the neuromuscular junctions [37]–[40].…”

Section: Resultsmentioning

confidence: 99%

Regeneration of Soft Tissues Is Promoted by MMP1 Treatment after Digit Amputation in Mice

Bellayr

Pan

et al. 2013

PLoS ONE

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The ratio of matrix metalloproteinases (MMPs) to the tissue inhibitors of metalloproteinases (TIMPs) in wounded tissues strictly control the protease activity of MMPs, and therefore regulate the progress of wound closure, tissue regeneration and scar formation. Some amphibians (i.e. axolotl/newt) demonstrate complete regeneration of missing or wounded digits and even limbs; MMPs play a critical role during amphibian regeneration. Conversely, mammalian wound healing re-establishes tissue integrity, but at the expense of scar tissue formation. The differences between amphibian regeneration and mammalian wound healing can be attributed to the greater ratio of MMPs to TIMPs in amphibian tissue. Previous studies have demonstrated the ability of MMP1 to effectively promote skeletal muscle regeneration by favoring extracellular matrix (ECM) remodeling to enhance cell proliferation and migration. In this study, MMP1 was administered to the digits amputated at the mid-second phalanx of adult mice to observe its effect on digit regeneration. Results indicated that the regeneration of soft tissue and the rate of wound closure were significantly improved by MMP1 administration, but the elongation of the skeletal tissue was insignificantly affected. During digit regeneration, more mutipotent progenitor cells, capillary vasculature and neuromuscular-related tissues were observed in MMP1 treated tissues; moreover, there was less fibrotic tissue formed in treated digits. In summary, MMP1 was found to be effective in promoting wound healing in amputated digits of adult mice.

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Section: Resultsmentioning

confidence: 99%

Regeneration of Soft Tissues Is Promoted by MMP1 Treatment after Digit Amputation in Mice

Bellayr

Pan

et al. 2013

PLoS ONE

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“…Another link between the immune and nervous system is given by the fact that the neural cell adhesion molecule (NCAM, CD56) is both expressed on mammalian neuronal and NK cells [23]. CD56 is highly conserved through vertebrate evolution and homologous sequences to CD56 have been reported in fish, too [24].…”

Section: Innate Immune Responses Roles Of the Innate Immune Systemmentioning

confidence: 99%

Inflammation in Fish As Seen from A Morphological Point of View with Special Reference to the Vascular Compartment

Koppang

Fischer²,

Satoh³

et al. 2007

CPD

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Modern bony fishes or teleosts are increasingly being used as model organisms for human diseases. Ambitious mapping programmes have revealed parts of or entire genomes of several species. This information suggests that there are several similarities between the mammalian and teleost immune systems, but also important differences. These differences are especially evident in the anatomical and functional constructions. However, compared to mammals, morphological studies of the immune system and in particular the inflammatory responses in fish are scarce, much due to a general lack of good cell markers. This review seeks to give an overview of the current knowledge of the teleost immune system related to inflammation and morphological research. The emphasis is placed on coronary changes which may be observed in salmonids over the size of 10 cm. Here, the immunopathological picture has some resemblance to that observed in similar changes in humans.

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“…However, RGCs express some regeneration‐associated molecules, such as the actin‐interacting protein gelsolin (Roth et al, 1999) or the recognition molecules zfNLRR (Bormann et al, 1999) and contactin1a (unpublished observations), at much higher levels during axon regrowth than during development. Conversely, the polysialic acid modification of NCAM is present on newly growing axons and not on regenerating axons (Harman et al, 2003). This suggests that the regulation of growth‐related genes in RGCs differs between development and regeneration.…”

Section: Regulation Of Growth‐associated Genes Differs Between Develomentioning

confidence: 99%

Growth and pathfinding of regenerating axons in the optic projection of adult fish

Becker

2006

J of Neuroscience Research

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In contrast to mammals, teleost fish are able to regrow severed long-range projection axons in the central nervous system (CNS), leading to recovery of function. The optic projection in teleost fish is used to study neuron-intrinsic and environmental molecular factors that determine successful axon regrowth and navigation through a complex CNS pathway back to original targets. Here we review evidence for regeneration-specific regulation and robust expression of growth- and pathfinding-associated genes in regenerating retinal ganglion cell (RGC) axons of adult fish. The environment of the CNS in fish appears to contain few inhibitory molecules and at the same time a number of promoting molecules for axon regrowth. Finally, some environmental cues that are used as guidance cues for developing RGC axons are also present in continuously growing adult animals. These molecules may serve as guidance cues for the precise navigation of axons from newly generated RGCs in adult animals as well as of regenerating RGC axons after a lesion. The application of new molecular techniques especially to adult zebrafish, is likely to produce new insights into successful axonal regeneration in the CNS of fish and the absence thereof in mammals.

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PSA-NCAM is up-regulated during optic nerve regeneration in lizard but not in goldfish

Cited by 9 publications

References 42 publications

Regeneration of Soft Tissues Is Promoted by MMP1 Treatment after Digit Amputation in Mice

Regeneration of Soft Tissues Is Promoted by MMP1 Treatment after Digit Amputation in Mice

Inflammation in Fish As Seen from A Morphological Point of View with Special Reference to the Vascular Compartment

Growth and pathfinding of regenerating axons in the optic projection of adult fish

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