PSA‐based screening for prostate cancer in asymptomatic younger males: Pilot study in blood donors

Reissigl, Andreas; Pointner, J.; Horninger, W.; Strasser, Hannes; Mayersbach, P.; Klocker, Helmut; Schönitzer, D; Bartsch, Georg

doi:10.1002/(sici)1097-0045(19970101)30:1<20::aid-pros3>3.3.co;2-a

Cited by 6 publications

(6 citation statements)

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“…24 In the smaller Austrian study, five detected tumours were localised and Gleason scores ranged from 4-8. 16 None of the prospective cohorts of younger men yet has sufficient follow-up to inform the debate on the long term outcome of these cancers detected by testing for prostate specific antigen. 24 In the only outcome data published in men younger than 50, survival without biochemical relapse (in the form of rising prostate specific antigen) after radical prostatectomy seemed better in younger men.…”

Section: Discussionmentioning

confidence: 99%

“…15 Prostate cancer was not found in two of the 44 Austrian blood donors with a prostate specific antigen value of at least 4.0 ng/ml who also had a suspicious result on digital rectal examination and a biopsy, but annual testing subsequently revealed six cases (detection rate 1.1%). 16 In a population based Austrian study, 28 of the 2054 men tested had a prostate specific antigen value of at least 2.5 ng/ml and three cases of prostate cancer were identified (1.2%). 17 In the prostate testing for cancer and treatment study, unselected men aged 50-69 have been invited for a prostate specific antigen test at nine UK centres since June 2001 to evaluate the effectiveness, cost effectiveness, and acceptability of treatments for clinically localised prostate cancer preceded by community based testing for prostate specific antigen.…”

Section: Introductionmentioning

confidence: 99%

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Detection of prostate cancer in unselected young men: prospective cohort nested within a randomised controlled trial

Lane

Howson

Donovan

et al. 2007

BMJ

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Objective To investigate the feasibility of testing for prostate cancer and the prevalence and characteristics of the disease in unselected young men. Design Prospective cohort nested within a randomised controlled trial, with two years of follow-up. Setting Eight general practices in a UK city. Participants 1299 unselected men aged 45-49. Intervention Prostate biopsies for participants with a prostate specific antigen level of 1.5 ng/ml or more and the possibility of randomisation to three treatments for those with localised prostate cancer. Main outcome measures Uptake of testing for prostate specific antigen; positive predictive value of prostate specific antigen; and prevalence of prostate cancer, TNM disease stage, and histological grade (Gleason score). Results 442 of 1299 men agreed to be tested for prostate specific antigen (34%) and 54 (12%) had a raised level. The positive predictive value for prostate specific antigen was 21.3%. Ten cases of prostate cancer were detected (2.3%) with eight having at least two positive results in biopsy cores and three showing perineural invasion. One tumour was of high volume (cT2c), Gleason score 7, with a positive result on digital rectal examination; nine tumours were cT1c, Gleason score 6, and eight had a negative result on digital rectal examination. Five of the nine eligible participants (55%) agreed to be randomised. No biochemical disease progression in the form of a rising prostate specific antigen level occurred in two years of follow-up. Conclusions Men younger than 50 will accept testing for prostate cancer but at a much lower rate than older men. Using an age based threshold of 1.5 ng/ml, the prevalence of prostate cancer was similar to that in older men (3.0 ng/ml threshold) and some cancers of potential clinical significance were found. Trial registration Current Controlled Trials ISRCTN20141297

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Detection of prostate cancer in unselected young men: prospective cohort nested within a randomised controlled trial

Lane

Howson

Donovan

et al. 2007

BMJ

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“…At the time of drawing blood for PSA measurement, no DRE was performed. Several scientific projects [7][8][9][10][11] have been published describing this screening program.…”

Section: Methodsmentioning

confidence: 87%

Screening for prostate cancer: updated experience from the tyrol study

Horninger

Berger²,

Pelzer³

et al. 2005

Current Prostate Reports

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“…Several reports [2][3][4][5][6][7] have been published describing this screening program. The screening project was performed in collaboration with general practitioners, medical examiners, urologists, medical laboratories, and the Tyrol Blood Bank of the Red Cross.…”

Section: Discussionmentioning

confidence: 99%