2016
DOI: 10.1016/j.gheart.2016.03.188
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PS240 Clinical and Hemodynamic Analysis of the Treatment With Ivabradine in Severe Aortic Stenosis

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“…Five studies have evaluated the use of ivabradine in patients with severe AS (Table 3). 53–57 Although no differences were noted in HR reduction, one study found ivabradine was associated with an increased LVEF compared to baseline therapy with β‐blockers 53 . Three studies found ivabradine decreased HR; two of these observed improvements in both LVEF and exercise tolerance 54–56 .…”
Section: Resultsmentioning
confidence: 99%
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“…Five studies have evaluated the use of ivabradine in patients with severe AS (Table 3). 53–57 Although no differences were noted in HR reduction, one study found ivabradine was associated with an increased LVEF compared to baseline therapy with β‐blockers 53 . Three studies found ivabradine decreased HR; two of these observed improvements in both LVEF and exercise tolerance 54–56 .…”
Section: Resultsmentioning
confidence: 99%
“… 53–57 Although no differences were noted in HR reduction, one study found ivabradine was associated with an increased LVEF compared to baseline therapy with β‐blockers 53 . Three studies found ivabradine decreased HR; two of these observed improvements in both LVEF and exercise tolerance 54–56 . In a study of 98 patients with severe AS, sinus rhythm, and preserved ejection fraction who were followed for 2.6 years, ivabradine was associated with a significantly lower risk of death from any cause, hospitalization, or the composite compared to standard care (e.g., β‐blockers) 57 …”
Section: Resultsmentioning
confidence: 99%