Abstract:Background:Globally, many screening programs for severe thalassemia (thal) syndromes use red blood cell (RBC) indices; mean corpuscular volume (MCV) <80 fl and/or mean corpuscular hemoglobin (MCH) <25 pg as cut‐off to identify thal disease and carriers. These criterion seem to be sensitive for individual with α°‐thal by two α‐globin gene deletions (‐‐/αα) and β‐thal traits. However this approach cannot be used for confidential identification α+‐thal trait (‐α/αα) due to a wide variation of baseline MCV a… Show more
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