Ps1173 protein Casein Kinase 2 Is Involved in Chronic Myeloid Leukemia Resistance to Imatinib and Also to Dasatinib

Abstract

0.0002), suggesting that telomeres are not age-dependent in CML at diagnosis. Analysing the clinical data, no significant correlation between ∆TL and clinical prognostic scores (Sokal and ELTS, with p = 0.816 and p = 0.314, respectively) was observed, nor between ∆TL and p210 BCR-ABL1 onco-protein isoforms (e13a2 and e14a2, p = 0.981). Finally, focusing on the ∆TL representing the difference between TL expected by age and TL determined in the CML cells, patients with lower ∆TL at diagnosis were significant associated with achievement of MR4.0 and MR4.