Ps-C08-7: Time in Therapeutic Range Is Not a Risk Factor for Cardiovascular Disease When Adjusted for Mean Systolic Blood Pressure

Abstract

Japan) were recruited. Each participant's BP was measured using the novel cuff-less BP monitoring device as well as a standard cuff-based sphygmomanometer under four different conditions: static, BP rising and falling, and reproducible after the one-month interval. The results of measurements under the four conditions were integrated and analyzed. The BP measurements were determined to be comparable between the standard cuff-based sphygmomanometer and the novel cuff-less earphone-type device, if the mean absolute difference (MAD) of the measurements was within 7 mmHg. We also performed Bland-Altman agreement analyses. Results:The participants' characteristics were as follows. Male to female ratio was approximately 50 % in both groups. Age was 27.5 [interquartile (IQR) 24.5-33.0] years old for the healthy subjects and 65.0 [IQR 49.5-74.0] years old for the patients with hypertension (HTN). BMI was 21.2 ] kg/m 2 and 23.8 .9] kg/ m 2 , respectively. MAD between the novel cuffless device and the reference using the standard cuff-based sphygmomanometer among the healthy subjects was 5.8 mmHg for systolic BP (SBP) and 5.3 mmHg for diastolic BP (DBP). MAD in the patients with HTN was 7.8 mmHg for SBP and 4.4 mmHg for DBP. In Bland-Altman agreement analyses, mean difference in the healthy subjects was 2.7 (95% confidence interval [CI] -13.4, 16.8) mmHg for SBP and 2.4 (95% CI -10.7, 15.5) mmHg for DBP. Mean difference in the patients with HTN was 0.9 (95% CI -20.0, 21.9) mmHg for SBP and 0.7 (95% CI -10.9, 12.3) mmHg for DBP. Conclusions:Our newly developed cuff-less earphone-type device based on green reflected photoplethysmography able to predict BP in healthy subjects, but it was difficult to predict SBP in the patients with HTN. Conclusions:Our study highlights the possible dependency relationship of exercise and adherence to medication. Results indicate that patients with good adherence to medication have better behavioral activation. There is need for further research in this domain, to confirm the findings.