PS-268 Stool Characteristics And Gastrointestinal Tolerance Of Chinese Infants Fed Term Formula Containing Increased Sn-2 Palmitate And Oligofructose: An Observational Study

Abstract

Background The feeding scheme of premature newborns changed in recent years. The latest recommendations emphasise the intensification both of parenteral and enteral nutrition from the first days of life. Methods We compared two groups of VLBW newborns born in our institution in 2010 and 2013. We analysed how the changes of our nutritional treatment influenced chosen parameters in both groups of newborns. Changes included: more intensive full TPN from first hours of life, earlier enteral nutrition (EN), faster increasing of EN, less restrictive fluid policy during first week of life, supplementation of proteins during EN and more exact growth charts. Results The demographic parameters of both groups were very similar. In 2013 compared to 2010 we found smaller average weight loss after birth (6,4% vs 9,7%; p < 0,05), faster return to birth weight (8 vs 12,5 days; p < 0,01) and higher average daily weight gain (21,5 vs 19,6 g/day; p < 0,05). The mean duration of TPN use was slightly shorter (18 vs 20 days; NS). Extra uterine growth restriction at the time of discharge decreased significantly but still was 43,3% in 2013. Improvement has taken place mainly in the subgroup of ELBW infants. The incidence of severe NEC declined from 10% in 2010 to 6,4% in 2013. Conclusions We revealed that our changes caused improvement of nutrition and brought beneficial effect on the growing parameters of our premature newborns without increasing the incidence of NEC. Background and aims Formula containing increased sn-2 palmitate with oligofructose (sn-2+OF) may improve stool consistency. We hypothesised that hard and watery stool incidence among infants fed a-lactalbumin-enriched formula with sn-2 +OF would be ≤2.5% (upper limit of 80% CI < 5.0%). Methods Healthy term infants (n = 440) aged~42 days were enrolled in this 48-day study on their current feeding regimens: formula-fed (n = 142), HM-fed (n = 143), or mixed-fed (n = 155). Stool consistency was assessed at 4 visits using a 3-day diary with validated 5-point scale (1 = watery, 5 = hard). Gastrointestinal (GI) tolerance was assessed using a validated questionnaire (score range = 13-65; lower values indicate better tolerance). Results Incidence of hard stools across visits ranged from 0.7% [80% CI: 0.1-2.7] to 2.1% [0.8-4.6] for formula-fed infants, with incidence rates ≤0.8% in mixed-fed, and no hard stools reported in HM-fed groups. Incidence of watery stools ranged PS-268

Infant feeding and health-related quality of life in healthy Chinese infants: results from a prospective, observational cohort study

“…Parents were free to switch their infant to other feeding regimens at any time during the study. Continued follow-up of these infants depended on the new feeding regimen and the timing of the switch relative to study days 15–17 (when parents completed the second of several three-day diaries on infant stool characteristics, another study outcome reported separately [ 19 ]). If the infant was switched to another of the three study feeding regimens (e.g., from exclusively breastfed to mixed-fed with study formula and breast milk) before the completion of the second three-day infant stool diary, the infant continued to participate in the study.…”