PS-155 Comparison Of Clinical And Electrophysiological Signs Of Encephalopathy In Neonates With Perinatal Asphyxia Qualifying For Hypothermia

Vilan, Ana; Vries, LS de; Sá‐Couto, Pedro; Haastert, IC van; Koopman-Esseboom, C.; Toet, MC; Groenendaal, Floris

doi:10.1136/archdischild-2014-307384.451

Cited by 2 publications

(1 citation statement)

References 2 publications

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“…Seventeen articles reported on aEEG recordings [6,[16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31]. Nine of those articles used the classification for background pattern by Hellström-Westas et al [32], 3 used the voltage pattern of al Naqueeb et al [33], and 3 studies used both methods.…”

Section: Amplitude-integrated Electroencephalographymentioning

confidence: 99%

Predictors of Outcomes in Hypoxic-Ischemic Encephalopathy following Hypothermia: A Meta-Analysis

et al. 2020

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Introduction: Prediction of neurodevelopmental outcome in infants with hypoxic-ischemic encephalopathy remains an important challenge. Various studies have shown that the predictive ability of different modalities changed after the introduction of therapeutic hypothermia. This paper reviews the diagnostic test accuracy of the different modalities that are being used to predict neurodevelopmental outcomes following therapeutic hypothermia. Methods: A systematic literature search was performed using Embase and PubMed. Two reviewers independently included eligible studies and extracted data. The quality of the studies was assessed using the Quality in Prognosis Studies Tool. Meta-analyses were performed where possible. Results: Forty-seven articles and 3 conference abstracts were included, reporting on 3,072infants of whom 39% died or had an adverse neurodevelopmental outcome. A meta-analysis could be performed using 37 articles on (amplitude-integrated) electroencephalography (EEG), conventional magnetic resonance imaging (MRI), diffusion-weighted imaging (DWI), and proton magnetic resonance spectroscopy (1H-MRS). Amplitude-integrated EEG (aEEG) at 24 and 72 h showed similar high diagnostic OR, while aEEG at 6 h and EEG performed less, both due to a low specificity. For MRI, most studies reported scoring systems in which early (<8 days) MRI performed better than late (≥8 days) MRI. Injury to the posterior limb of the internal capsule on MRI or to the thalami on DWI were strong individual predictors, as was an increased lactate/N-acetylaspartate peak on 1H-MRS. Conclusions: In the era of therapeutic hypothermia, the different modalities remain good predictors of neurodevelopmental outcome. However, timing should be taken into account. aEEG may initially be false positive and gets more reliable after 24 h. In contrast, MRI should be used during the first week, as its predictive value decreases afterwards.

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Section: Amplitude-integrated Electroencephalographymentioning

confidence: 99%

Predictors of Outcomes in Hypoxic-Ischemic Encephalopathy following Hypothermia: A Meta-Analysis

et al. 2020

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Investigation of perinatal asphyxia in term newborns with postnatal feeding intolerance

Emreciksin,

Taş,

Danış

et al. 2024

Northwestern Med J

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Aim: Perinatal asphyxia affects whole body systems and depending on compensation mechanisms, the central nervous system is primarily protected. In this study, we aimed to evaluate brain electrophysiological activity in cases with postnatal feeding intolerance due to perinatal asphyxia and to investigate whether the compensation mechanism is adequate or whether there is a minimal electrophysiological disorder. Methods: This study was conducted prospectively to compare the amplitude electroencephalography (EEG) recordings of 22 patients who were followed up with the diagnosis of feeding intolerance due to perinatal asphyxia and 10 control groups. Eeg probes were applied by gluing. Conventional EEG was performed in the patient group and the recordings were evaluated with an amplitude integrated electroencephalography (aEEG). It was also compared with feeding time, length of hospital stay, maternal ages, cord blood gas pH and base deficit values, electrolyte values at the 24th hour, appearance pulse grimace activity and respiration (APGAR) and Burdjalov scores. Results: When aEEG Vmin values, Burdjalov scores, and 1st min APGAR scores were compared, statistically significant difference was found between the patient and control groups. There was an inverse weak correlation between the patients' aEEG Vmin values and their length of hospital stay. A weak correlation was found between the cases’ cord blood gas base deficit and aEEG Vmax values. When cases were divided into two groups as less than 7 days of hospitalization and more than 7 days of hospitalization, a statistically significant difference was found between the groups in terms of maternal age. Conclusion: In our study, it was aimed to show whether there is a minimal effect of perinatal asphyxia on EEG findings in newborns with nutritional deficiency. The difference in the aEEG Vmin values of the case and control groups indicates that brain electrical activity is affected. This is also supported by the fact that those with higher Vmin values had shorter hospital stays.

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PS-155 Comparison Of Clinical And Electrophysiological Signs Of Encephalopathy In Neonates With Perinatal Asphyxia Qualifying For Hypothermia

Cited by 2 publications

References 2 publications

Predictors of Outcomes in Hypoxic-Ischemic Encephalopathy following Hypothermia: A Meta-Analysis

Predictors of Outcomes in Hypoxic-Ischemic Encephalopathy following Hypothermia: A Meta-Analysis

Investigation of perinatal asphyxia in term newborns with postnatal feeding intolerance

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