PS-100 Blood Pressure And Aortic Distensibility As Early Markers Of An Increased Cardiovascular Risk In Preschool Children Born Preterm – Preliminary Data
Abstract:Background Using an age-appropriate new dobutamine formulation, the aims of the study were: to validate superior vena cava flow (SVCF) as a marker of cardiac output (CO), and to study drug-related changes in haemodynamics and oxygen metabolism in response to escalating doses of dobutamine in hypoxic neonatal piglets. Methods 2-days-old-piglets were exposed to hypoxia (10-15% oxygen) for 2 h followed by reoxigenation with 21-30% oxygen for 6 h. After 60-min of reoxigenation, 18 piglets were randomised to: Contr… Show more
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