PS-08-008 Relation Between Monocyte to High-Density Lipoprotein Cholesterol Ratio with Presence and Severity of Erectile Dysfunction

Yücetaş, Uğur; Kadıhasanoğlu, Mustafa; Karabay, Ezgi Aktaş; Erkan, Esin; Ozbek, Erol

doi:10.1016/j.jsxm.2017.03.003

Cited by 2 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It has been shown that high monocyte count and low HDL-C levels may be relevant to inflammation (Acikgoz et al, 2017;Bolayir et al, 2017;Kundi et al, 2015;You et al, 2017;Yucetas, Kadihasanoglu, Karabay, Erkan, & Ozbek, 2017) and oxidative stress (Acikgoz et al, 2017), and it has been reported that the MHR is a new prognostic marker in several CVDs (Karataş et al, 2016;M. S. Cetin et al, 2016;You et al, 2017).…”

Section: Mhr As a Prognostic Markermentioning

confidence: 99%

“…It has been shown that high monocyte count and low HDL‐C levels may be relevant to inflammation (Acikgoz et al, ; Bolayir et al, ; Kundi et al, ; You et al, ; Yucetas, Kadihasanoglu, Karabay, Erkan, & Ozbek, ) and oxidative stress (Acikgoz et al, ), and it has been reported that the MHR is a new prognostic marker in several CVDs (Karataş et al, ; M. S. Cetin et al, ; You et al, ). The initial model for the prediction of coronary atherosclerotic regression using the evaluation of HDL‐C level and the peripheral blood monocyte count was derived from a study showing that the significant regression in the plaque volume after pravastatin therapy was associated with a simultaneous elevation in serum HDL‐C ( β = −0.56) and a decrease in blood monocyte count ( β = 0.23).…”

Section: Mhr As a Prognostic Markermentioning

confidence: 99%

See 1 more Smart Citation

Monocyte‐to‐HDL‐cholesterol ratio as a prognostic marker in cardiovascular diseases

Ganjali

Gotto

Ruscica

et al. 2018

Journal Cellular Physiology

196

167

View full text Add to dashboard Cite

Inflammation and lipid accumulation are two basic hallmarks of atherosclerosis as a chronic disease. Inflammation not only is a local response but can also be considered as a systemic process followed by an elevation of inflammatory mediators. Monocytes are a major source of proinflammatory species during atherogenesis. In atherosclerosis, modified low-density lipoproteins (LDLs) are removed by macrophages; these are recruited in the vessel wall, inducing the release of inflammatory cytokines in inflamed tissue. Hence, inflammatory cholesterol ester-loaded plaque is generated. High-density lipoprotein-cholesterol (HDL-C) exhibits antiatherosclerotic effects by neutralizing the proinflammatory and pro-oxidant effects of monocytes via inhibiting the migration of macrophages and LDL oxidation in addition to the efflux of cholesterol from these cells. Furthermore, HDL plays a role in suppressing the activation of monocytes and proliferation-differentiation of monocyte progenitor cells. Thus, accumulation of monocytes and reduction of HDL-C may participate in atherosclerosis and cardiovascular diseases (CVD). Given that the relationship between the high number of monocytes and low HDL-C levels has been reported in inflammatory disorders, this review focused on understanding whether the monocyte-to-HDL ratio could be a convenient marker to predict atherosclerosis development and progression, hallmarks of CV events, instead of the individual monocyte count or HDL-C level.

show abstract