Ps 02-19 Apolipoprotein Levels in Patients With Acute Coronary Syndrome

Cunanan, Elleen L.; Barcelon-Cruz, M.I.; Punzalan, Felix Eduardo R.; Llanes, Elmer Jasper B.; Gonzales, Lourdes Ella; Reganit, Paul Ferdinand M.; Taquiso, Jezreel L.; Sy, Rody G.

doi:10.1097/01.hjh.0000500148.55418.f5

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“…Thus, the ApoB/ApoA-1 ratio could be classified as a sensitive marker for atherogenic risks [ 17 ]. Additionally, Cunanan et al investigated 95 patients with ACS and revealed the existence of elevated Apo B levels [ 18 ].…”

Section: Discussionmentioning

confidence: 99%

The relation between ApoB/ApoA-1 ratio and the severity of coronary artery disease in patients with acute coronary syndrome

2021

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Background Apolipoprotein B is considered the primary protein constituent of low-density lipoprotein. LDL contains variable quantities of cholesterol, but each lipoprotein contains a single ApoB protein. Thus, ApoB is a better index for the LDL circulation if compared to LDL cholesterol. On the contrary, apolipoprotein A-1 is a main structural protein of high-density lipoprotein. It has a major role in reversing cholesterol flow and cellular cholesterol homeostasis once detected. The aim of the study is to measure apo B/apo A-1 ratio in patients with acute coronary syndrome and assess its relationship with the severity of CAD. A total of 90 patients were enrolled in the study and subdivided into 3 groups: 30 patients of STEMI, 30 patients of NSTEMI, and 30 patients presented with unstable angina. Serum levels of apolipoprotein A-1 and apolipoprotein B were properly measured upon admission, and apo B/apo A-1 ratio was calculated. Results Both of Apo B and Apo B/Apo A1 ratio correlated significantly with Gensini scores (P value <0.001). High Gensini score patients had significantly high Apo B/Apo A1 ratio with the best cutoff value of 0.8 with sensitivity of 90% and specificity of 70%. Conclusion Apo B is an independent risk predictor for the severity of CAD in patients with acute coronary syndromes. Moreover, the Apo B/Apo A1 ratio remains highly significant in patients with high Gensini score.

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Section: Discussionmentioning

confidence: 99%