Przewlekła ekspozycja na hałas a niedobór testosteronu — metaanaliza i metaregresja wyników badań na gryzoniach

Abstract

Introduction: Chronic psychological distress can cause suppression of the hypothalamic-pituitary-testicular axis and thus lead to male hypogonadism, which is associated with psycho-social dysfunction, chronic diseases, and as a result, considerable economic costs. Conversely, noise is a prototypal environmental stressor of growing importance, already linked to birth outcomes and diabetes. However, its effects on male testosterone levels have been paid little attention. Material and methods: This paper reports a systematic review and meta-analysis of experimental studies in rodents, which have examined the effect of chronic noise stress on serum testosterone levels. A systematic search in MEDLINE, EMBASE and the Internet yielded seven studies. A quality effects meta-analytical model was applied to compute pooled Hedges's g. Quality effects meta-regression was carried out as well. Results: We found pooled Hedges's g of -2.41 (95% CI: -3.28, -1.54), indicating a very large effect of noise exposure on testosterone. Metaregression confirmed that the overall duration of exposure explained a significant proportion of the variance across individual effect sizes (Q (1) = 3.95, p = 0.047). However, there was considerable inter-study heterogeneity (I 2 = 82%) and publication bias (p = 0.016). After inputting two studies previously thought to be missing, the pooled effect dropped to g = -1.53 (95% CI: -3.01, -0.05). Conclusions: Chronic noise exposure of ≈ 100 dB leads to a significant reduction of serum testosterone in male rodents. Research on humans is highly warranted, especially given the steady trend in Western societies for increasing the burden of both male hypogonadism and noise pollution.

Workplace noise exposure and serum testosterone in men enrolled in the 1999-2004 National Health and Nutrition Examination Survey

“…Self-reported exposure to loud noise was also associated with lower TT, but the effect was statistically significant only among those aged ≥37 years. Our findings are in line with the relationship established in animal experiments (12), but adequate comparisons cannot be made with epidemiological studies in humans.…”

“…Because environmental noise acts as a stressor and stimulates the HPA axis, it has been implicated as a risk factor for testosterone deficiency (10)(11)(12). There is compelling evidence from animal experiments that chronic noise exposure is associated with reduced testosterone in males: a meta-analysis (12) pooled seven laboratory studies and found that rodents exposed to about 100 dB for several weeks had more than two standard deviations lower serum testosterone than the controls.…”

“…There is compelling evidence from animal experiments that chronic noise exposure is associated with reduced testosterone in males: a meta-analysis (12) pooled seven laboratory studies and found that rodents exposed to about 100 dB for several weeks had more than two standard deviations lower serum testosterone than the controls. The longer the exposure was, the larger the adverse effect.…”

Occupational noise and ischemic heart disease: A systematic review

“…[3] Animal models have even shown that chronic noise exposure reduces male testosterone levels, which, on the other hand, might further impair their cardiovascular system. [8]…”