Prussian Blue Nanoparticles as Multienzyme Mimetics and Reactive Oxygen Species Scavengers

Abstract

The generation of reactive oxygen species (ROS) is an important mechanism of nanomaterial toxicity. We found that Prussian blue nanoparticles (PBNPs) can effectively scavenge ROS via multienzyme-like activity including peroxidase (POD), catalase (CAT), and superoxide dismutase (SOD) activity. Instead of producing hydroxyl radicals (•OH) through the Fenton reaction, PBNPs were shown to be POD mimetics that can inhibit •OH generation. We theorized for the first time that the multienzyme-like activities of PBNPs were likely caused by the abundant redox potentials of their different forms, making them efficient electron transporters. To study the ROS scavenging ability of PBNPs, a series of in vitro ROS-generating models was established using chemicals, UV irradiation, oxidized low-density lipoprotein, high glucose contents, and oxygen glucose deprivation and reperfusion. To demonstrate the ROS scavenging ability of PBNPs, an in vivo inflammation model was established using lipoproteins in Institute for Cancer Research (ICR) mice. The results indicated that PBNPs hold great potential for inhibiting or relieving injury induced by ROS in these pathological processes.

An Enzyme‐Mimicking Single‐Atom Catalyst as an Efficient Multiple Reactive Oxygen and Nitrogen Species Scavenger for Sepsis Management

“…To evaluate whether Co/PMCS was potent in the sepsis redox cycle (Supporting Information, Figure S23), the negligible cytotoxicity and efficient cellular internalization were first confirmed (see the Supporting Information, Figure S24 and S25 in detail) . Then, the intracellular antioxidative activities of Co/PMCS were investigated for reducing inflammation which were stimulated with LPS, H 2 O 2 , CuSO 4 , and Rosup, respectively .…”

Molecular and cellular mechanisms for zoledronic acid-loaded magnesium-strontium alloys to inhibit giant cell tumors of bone

“…6D and 9C. ROS could be formed in the cells as a result of oxidative phosphorylation in the mitochondria and excessive ROS production can induce apoptotic cell death, meaning that ROS generation is probably the upstream regulator of apoptosis [34]. …”

Hollow Structures Based on Prussian Blue and Its Analogs for Electrochemical Energy Storage and Conversion

“…[2][3][4][5][6][7][8][9] Motivated by the discovery of carbon nanotubes and fullerenes, scientists have devoted many efforts in exploiting nanomaterials with a hollow interior, for example hollow polyhedra and spheres, tubes, open cages, and frames, which has become an intriguing research topic over the past two decades. [44,45] As a result, PB and PBA materials find promising applications in catalysis, [46,47] photothermal therapy, [48] information storage, [37] sensor, [38] and energy storage and conversion. [17,[22][23][24][25][26][28][29][30][31][32] Nowadays, www.advmat.de www.advancedsciencenews.com structural traits and diverse chemical compositions, the electronic properties of the PB and PBA materials can be tailored by external stimulus, e.g., magnetic/electric field, [39,40] photoradiation, [41] temperature, [42] pressure, [43] and chemical modifications.…”