Prussian blue coated gold nanoparticles for simultaneous photoacoustic/CT bimodal imaging and photothermal ablation of cancer

Jing, Lijia; Liang, Xiaolong; Deng, Zijian; Feng, Shouhua; Li, Xiaoda; Huang, Minhua; Li, Changhui; Dai, Zhifei

doi:10.1016/j.biomaterials.2014.04.005

Cited by 271 publications

(188 citation statements)

References 36 publications

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“…PB is a prototype of mixed‐valence transition metal hexacyanoferrates with the general formula of Fe III 4 [Fe II (CN) 6 ] 3 ·nH2O. Because of the absorbance in the near‐infrared (NIR) window, high photothermal conversion efficiency, T1‐weighted magnetic resonance contrasting ability and approved human safety, PB nanoparticles have been explored for magnetic resonance (MR) imaging, photoacoustic (PA) imaging, and photothermal therapy (PTT) 27, 28, 29, 30, 31, 32. However, pure PB nanoparticles cannot deliver drug for cancer chemotherapy because of their small micropores and limited loading capacity.…”

Section: Introductionmentioning

confidence: 99%

Periodic Mesoporous Organosilica Coated Prussian Blue for MR/PA Dual‐Modal Imaging‐Guided Photothermal‐Chemotherapy of Triple Negative Breast Cancer

Tian

et al. 2016

Advanced Science

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Complete eradication of highly aggressive triple negative breast cancer (TNBC) remains a notable challenge today. In this work, an imaging‐guided photothermal‐chemotherapy strategy for TNBC is developed for the first time based on a periodic mesoporous organosilica (PMO) coated Prussian blue (PB@PMO) nanoplatform. The PB@PMOs have organic‐inorganic hybrid frameworks, uniform diameter (125 nm), high surface area (866 m2 g−1), large pore size (3.2 nm), excellent photothermal conversion capability, high drug loading capacity (260 µg mg−1), and magnetic resonance (MR) and photoacoustic (PA) imaging abilities. The MR and PA properties of the PB@PMOs are helpful for imaging the tumor and showing the accumulation of the nanoplatform in the tumor region. The bioluminescence intensity and tumor volume of the MDA‐MB‐231‐Luc tumor‐bearing mouse model demonstrate that TNBC can be effectively inhibited by the combined photothermal‐chemotherapy than monotherapy strategy. Histopathological analysis further reveals that the combination therapy results in most extensive apoptotic and necrotic cells in the tumor without inducing obvious side effect to major organs.

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Section: Introductionmentioning

confidence: 99%

Periodic Mesoporous Organosilica Coated Prussian Blue for MR/PA Dual‐Modal Imaging‐Guided Photothermal‐Chemotherapy of Triple Negative Breast Cancer

Tian

et al. 2016

Advanced Science

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“…Despite the lack of surface functionalization, CT signal continued to increase over the time course. Biodistribution studies revealed the highest accumulation was in the spleen [104].…”

Section: Passively Targeted Gold Nanoparticle Formulationsmentioning

confidence: 97%

“…In the agar gel, increasingly thick layers of tissue were placed in the laser path to investigate signal penetration depth. High resolution was achieved in the absence of tissue, while an increasing loss of clarity was evident up to ∼ 4.3 cm [104]. Cheheltani et al encapsulated AuNP into polydi(carboxylatophenoxy)phosphazene (PCPP) nanospheres.…”

Section: Photoacoustic Imagingmentioning

confidence: 99%

Gold Nanoparticles as X-Ray, CT, and Multimodal Imaging Contrast Agents: Formulation, Targeting, and Methodology

Mahan

Doiron

2018

Journal of Nanomaterials

101

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Computed tomography (CT) is among the most popular medical imaging modalities due to its high resolution images, fast scan time, low cost, and compatibility with all patients. CT scans of soft tissues require the localization of imaging contrast agents (CA) to create contrast, revealing anatomic information. Gold nanoparticles (AuNP) have attracted interest recently for their use as CT CA due to their high X-ray attenuation, simple surface chemistry, and biocompatibility. Targeting molecules may be attached to the particles to allow for the targeting of specific cell types and disease states. AuNP can also be readily designed to incorporate other imaging contrast agents such as rare earth metals and dyes. This review summarizes the current state-of-the-art knowledge in the field of AuNP used as X-ray and multimodal contrast agents. Primary research is analyzed through the lens of structure-propertyfunction to best explain the design of a particle for a given application. Design specification of particles includes size, shape, surface functionalization, composition, circulation time, and component synergy. Key considerations include delivery of a CA payload to the site of interest, nontoxicity of particle components, and contrast enhancement compared to the surrounding tissue. Examples from literature are included to illustrate the strategies used to address design considerations.

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“…It exhibits the properties of intrinsic paramagnetism, which negatively enhances magnetic resonance imaging (MRI) T2-weighted contrast. In particular, owing to the tunable morphology of PB in the forms of solid, shell, or hollow nanostructures, [28][29][30][31] it allows PB, as a versatile drug carrier, to deliver drugs into the tumor site with high drug-loading efficiency. 32 Our previous research has demonstrated that hollow mesoporous PB nanoparticles (HMPBs) can be used to encapsulate chemotherapeutic drugs and perfluorohexane (PFH), thereby enhancing HIFU therapy in subcutaneous xenograft tumors.…”

Section: Introductionmentioning

confidence: 99%

Mesoporous composite nanoparticles for dual-modality ultrasound/magnetic resonance imaging and synergistic chemo-/thermotherapy against deep tumors

Zhang

Wang

Hao

et al. 2017

IJN

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High-intensity focused ultrasound (HIFU) is a promising and noninvasive treatment for solid tumors, which has been explored for potential clinical applications. However, the clinical applications of HIFU for large and deep tumors such as hepatocellular carcinoma (HCC) are severely limited by unsatisfactory imaging guidance, long therapeutic times, and damage to normal tissue around the tumor due to the high power applied. In this study, we developed doxorubicin/perfluorohexane-encapsulated hollow mesoporous Prussian blue nanoparticles (HMPBs-DOX/PFH) as theranostic agents, which can effectively guide HIFU therapy and enhance its therapeutic effects in combination with chemotherapy, by decreasing the cavitation threshold. We investigated the effects of this agent on ultrasound and magnetic resonance imaging in vitro and in vivo. In addition, we showed a highly efficient HIFU therapeutic effect against HCC tumors, as well as controlled drug release, owing to the phase-transitional performance of the PFH. We therefore conclude that HMPB-DOX/PFH is a safe and efficient nanoplatform, which holds significant promise for cancer theranostics against deep tumors in clinical settings.

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Prussian blue coated gold nanoparticles for simultaneous photoacoustic/CT bimodal imaging and photothermal ablation of cancer

Cited by 271 publications

References 36 publications

Periodic Mesoporous Organosilica Coated Prussian Blue for MR/PA Dual‐Modal Imaging‐Guided Photothermal‐Chemotherapy of Triple Negative Breast Cancer

Periodic Mesoporous Organosilica Coated Prussian Blue for MR/PA Dual‐Modal Imaging‐Guided Photothermal‐Chemotherapy of Triple Negative Breast Cancer

Gold Nanoparticles as X-Ray, CT, and Multimodal Imaging Contrast Agents: Formulation, Targeting, and Methodology

Mesoporous composite nanoparticles for dual-modality ultrasound/magnetic resonance imaging and synergistic chemo-/thermotherapy against deep tumors

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