Prussian blue-based theranostics for ameliorating acute kidney injury

Zhang, Dongyang; Liu, Hengke; Zhu, Kathy S.; He, Ting; Younis, Muhammad Rizwan; Yang, Chen; Shan, Lei; Wu, Jiayingzi; Lin, Jing; Qu, Junle; Huang, Peng

doi:10.1186/s12951-021-01006-z

Cited by 32 publications

(33 citation statements)

References 76 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Other antioxidant nanozymes have also been used in AKI treatment, including copper (Cu) nanozymes [ 199 ], Prussian blue (PB) nanozymes [ 200 ], and melanin nanozymes [ 202 ]. These nanozymes all have properties of various types of antioxidant enzymes and small size for AKI treatment.…”

Section: Antioxidant Nanozymesmentioning

confidence: 99%

Nanodrugs alleviate acute kidney injury: Manipulate RONS at kidney

Chen

Nan

Yang

et al. 2023

Bioactive Materials

View full text Add to dashboard Cite

Section: Antioxidant Nanozymesmentioning

confidence: 99%

Nanodrugs alleviate acute kidney injury: Manipulate RONS at kidney

Chen

Nan

Yang

et al. 2023

Bioactive Materials

View full text Add to dashboard Cite

“…Moreover, PBNPs have been shown to be safe and biocompatible and have been approved by the US Food and Drug Administration (FDA) for clinical use . Mechanistically, PBNPs have been demonstrated to readily remove excessive ROS in vitro, exhibiting therapeutic efficacy in the context of acute pancreatitis, hepatic injury, ischemic stroke, acute kidney injury, inflammatory bowel disease, and cutaneous wound healing. − …”

Section: Introductionmentioning

confidence: 99%

Thermosensitive Hydrogel Incorporating Prussian Blue Nanoparticles Promotes Diabetic Wound Healing via ROS Scavenging and Mitochondrial Function Restoration

Zhao

Liu

et al. 2022

ACS Appl. Mater. Interfaces

102

View full text Add to dashboard Cite

Diabetic foot ulcer is a serious complication in diabetes patients, imposing a serious physical and economic burden to patients and to the healthcare system as a whole. Oxidative stress is thought to be a key driver of the pathogenesis of such ulcers. However, no antioxidant drugs have received clinical approval to date, underscoring the need for the further development of such medications. Hydrogels can be applied directly to the wound site, wherein they function to prevent infection and maintain local moisture concentrations, in addition to serving as a reservoir for the delivery of a range of therapeutic compounds with the potential to expedite wound healing in a synergistic manner. Herein, we synthesized Prussian blue nanoparticles (PBNPs) capable of efficiently scavenging reactive oxygen species (ROS) owing to their ability to mimic the activity of catalase (CAT), peroxidase (POD), and superoxide dismutase (SOD). In the context of in vitro oxidative stress, these PBNPs were able to protect against cytotoxicity, protect mitochondria from oxidative stress-related damage, and restore nuclear factor erythroid 2-related factor 2 (NRF2)/heme oxygenase-1 (HO-1) pathway activity. To expand on these results in an in vivo context, we prepared a thermosensitive poly (d,L-lactide)-poly(ethylene glycol)-poly(d,L-lactide) (PDLLA-PEG-PDLLA) hydrogel (PLEL)-based wound dressing in which PBNPs had been homogenously incorporated, and we then used this dressing as a platform for controlled PBNP release. The resultant PBNPs@PLEL wound dressing was able to improve diabetic wound healing, decrease ROS production, promote angiogenesis, and reduce pro-inflammatory interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) levels within diabetic wounds. Overall, our results suggest that this PBNPs@PLEL platform holds great promise as a treatment for diabetic foot ulcers.

show abstract

“…Imaging diagnosis includes ultrasound, computed tomography etc. can assess kidney morphology and provide insights into the function, perfusion, and possible etiology for AKI 19 , 20 . However, these methods have disadvantages such as low resolution, radiation damage, and the potential risk of increased nephrotoxicity caused by contrast agents, and is not suitable for the diagnosis of early AKI.…”

Section: Introductionmentioning

confidence: 99%

Emerging early diagnostic methods for acute kidney injury

Xiao¹,

Huang²,

Yang³

et al. 2022

Theranostics

View full text Add to dashboard Cite

Many factors such as trauma and COVID-19 cause acute kidney injury (AKI). Late AKI have a very high incidence and mortality rate. Early diagnosis of AKI provides a critical therapeutic time window for AKI treatment to prevent progression to chronic renal failure. However, the current clinical detection based on creatinine and urine output isn't effective in diagnosing early AKI. In recent years, the early diagnosis of AKI has made great progress with the advancement of information technology, nanotechnology, and biomedicine. These emerging methods are mainly divided into two aspects: First, predicting AKI through models construct by machine learning; Second, early diagnosis of AKI through detection of newly-discovered early biomarkers. Currently, these methods have shown great potential and become an attractive tool for the early diagnosis of AKI. Therefore, it is very important to discuss and summarize these methods for the early diagnosis of AKI. In this review, we first systematically summarize the application of machine learning in AKI prediction algorithms and specific scenarios. In addition, we introduce the key role of early biomarkers in the progress of AKI, and then comprehensively summarize the application of emerging detection technologies for early AKI. Finally, we discuss current challenges and prospects of machine learning and biomarker detection. The review is expected to provide new insights for early diagnosis of AKI, and provided important inspiration for the design of early diagnosis of other major diseases.

show abstract

Prussian blue-based theranostics for ameliorating acute kidney injury

Cited by 32 publications

References 76 publications

Nanodrugs alleviate acute kidney injury: Manipulate RONS at kidney

Nanodrugs alleviate acute kidney injury: Manipulate RONS at kidney

Thermosensitive Hydrogel Incorporating Prussian Blue Nanoparticles Promotes Diabetic Wound Healing via ROS Scavenging and Mitochondrial Function Restoration

Emerging early diagnostic methods for acute kidney injury

Contact Info

Product

Resources

About