Pruritus in Pregnancy

Stefaniak, Aleksandra; Pereira, Manuel P.; Zeidler, Claudia; Ständer, Sonja

doi:10.1007/s40257-021-00668-7

Cited by 19 publications

(17 citation statements)

References 158 publications

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“…Early diagnosis and prognosis of ICP patients are therefore of essential clinical significance. Currently, the clinical diagnosis of ICP is largely based on the corresponding clinical symptoms [ 30 ] and laboratory criteria [ 31 ]. These standards, however, do not serve as the gold standard for diagnosis because of their flaws.…”

Section: Discussionmentioning

confidence: 99%

Unique microRNA expression profiles in plasmic exosomes from intrahepatic cholestasis of pregnancy

Zhan

Chen

Deng

et al. 2023

BMC Pregnancy Childbirth

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Background Intrahepatic cholestasis of pregnancy (ICP) is strongly associated with an increased risk of adverse perinatal outcomes. Total bile acid (TBA) levels in the late second or third trimester are a major factor in the diagnosis. Here, we sought to establish the miRNA expression profile of plasm exosomes of ICP and identify possible biomarkers for the diagnosis of ICP. Methods This case–control study involved 14 ICP patients as the experimental group and 14 healthy pregnant women as the control group. Electron microscopy was used to observe the presence of exosomes in plasma. Nanosight and Western blotting of CD63 was used to assess exosome quality. Among them, three ICP patients and three controls were used for isolation plasmic exosome and preliminary miRNA array analysis. The Agilent miRNA array was utilized to dynamically monitor the miRNA expression in plasmic exosomes of included patients in the first trimester(T1), second trimester (T2), third trimester (T3), and delivery (T4). Then, Quantitative real-time Polymerase chain reaction was used to identify and validate differentially expressed miRNAs in plasma-derived exosomes. Results The expression levels of hsa-miR-940, hsa-miR-636, and hsa-miR-767-3p in plasma-derived exosomes of ICP patients were significantly higher than those of healthy pregnant women. Besides, these three miRNAs were also significantly up-regulated at the plasma, placental, and cellular levels (P < 0.05). The diagnostic accuracy of hsa-miR-940, hsa-miR-636, and hsa-miR-767-3p was further evaluated by the ROC curve, the area under the curve (AUC) values for each were 0.7591, 0.7727, and 0.8955, respectively. Conclusions We identified three differentially expressed miRNAs in the plasma exosomes of ICP patients. Hence, hsa-miR-940, hsa-miR-636, and hsa-miR-767-3p may be potential biomarkers for enhancing the diagnosis and prognosis of ICP.

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Section: Discussionmentioning

confidence: 99%

Unique microRNA expression profiles in plasmic exosomes from intrahepatic cholestasis of pregnancy

Zhan

Chen

Deng

et al. 2023

BMC Pregnancy Childbirth

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“…Also, pruritus is one of the leading dermatological symptoms during gestation and has been estimated to experience in 18%–40% of pregnancies. In addition to being related to specific dermatoses of pregnancy, pruritus may occur from exacerbation of preexisting dermatoses, and dermatoses that coincidently develop during gestation 25 . Thus, a novel biomarker should be determined that represents a useful diagnostic tool for pregnancies complicated with chronic pruritus.…”

Section: Discussionmentioning

confidence: 99%

“…In addition to being related to specific dermatoses of pregnancy, pruritus may occur from exacerbation of preexisting dermatoses, and dermatoses that coincidently develop during gestation. 25 Thus, a novel biomarker should be determined that represents a useful diagnostic tool for pregnancies complicated with chronic pruritus. This biomarker, clarifying ICP from the differential diagnosis, could assist clinicians in treating these patients sufficiently.…”

Section: Discussionmentioning

confidence: 99%

Serum autotaxin levels correlate with the severity of pruritus in intrahepatic cholestasis of pregnancy

Çaypınar

Oğlak

Behram³

et al. 2022

J of Obstet and Gynaecol

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Purpose This study aimed to examine autotaxin (ATX) concentrations in the serum of pregnant women complicated with intrahepatic cholestasis of pregnancy (ICP) and compare them with individuals with uncomplicated healthy pregnancies. Methods This prospective case–control study took place with 83 pregnant women. The study group included 43 pregnant women presenting with a singleton pregnancy diagnosed with ICP in their third trimester of pregnancy. The diagnostic power of the ATX variable was examined by receiver operating characteristic analysis, and the cut‐off value calculated according to the Youden index was summarized with the related sensitivity and specificity points. Results The mean serum concentration of maternal ATX was significantly higher in the ICP cases (8.91 ± 2.69 pg/mL) compared to the pregnant women in the control group (3.59 ± 1.39 ng/mL, p < 0.001). According to the Youden index, a 5.80 ng/mL cut‐off value of serum ATX concentrations can be used to diagnose ICP with 97.7% sensitivity and 97.5% specificity. A significant highly positive correlation was found between maternal serum ATX levels and maternal serum total bile acid levels (r = 0.633 and p < 0.001) and itch intensity, which was objectified by the visual analog scale score (r = 0.951 and p < 0.001). Conclusion Maternal serum ATX levels were significantly increased in ICP patients as compared with healthy pregnant women. Also, serum ATX activity was highly correlated with the itch intensity. We consider that ATX might represent a robust, accurate, and reliable circulating biomarker to diagnose ICP.

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“…En DA grave que requiere manejo sistémico, el MTX, el MMF y los iJAK están contraindicados en embarazo y lactancia y deben suspenderse al menos tres meses antes de la concepción. CyA o AZA pueden usarse en embarazo con precaución (cuadro 18) y monitorizando bienestar fetal, mientras que los datos de seguridad de agentes biológicos como dupilumab se limitan a pequeñas series de casos, lo que no es suficiente para recomendar su uso actualmente 120,141 .…”

Section: Da En La Paciente Embarazada Y Durante La Lactanciaunclassified

Guía de dermatitis atópica para México (GUIDAMEX): lineamientos usando metodología ADAPTE

Larenas‐Linnemann¹,

Rincón-Pérez²,

Luna-Pech³

et al. 2023

GMM

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Pruritus in Pregnancy

Cited by 19 publications

References 158 publications

Unique microRNA expression profiles in plasmic exosomes from intrahepatic cholestasis of pregnancy

Unique microRNA expression profiles in plasmic exosomes from intrahepatic cholestasis of pregnancy

Serum autotaxin levels correlate with the severity of pruritus in intrahepatic cholestasis of pregnancy

Guía de dermatitis atópica para México (GUIDAMEX): lineamientos usando metodología ADAPTE

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