Pruritus in Black Skin: Unique Molecular Characteristics and Clinical Features

McColl, Michael; Boozalis, Emily; Aguh, Crystal; Eseonu, Amarachi; Okoye, Ginette A.; Kwatra, Shawn G.

doi:10.1016/j.jnma.2020.07.002

Cited by 28 publications

(29 citation statements)

References 53 publications

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“…[16][17][18] Greater severity of AD in Black children compared to White children was reported in one study after adjusting the erythema score in the Score Atopic Dermatitis index (SCORAD). 19,20 Prevalence and impact of pruritus have also been greater in Blacks than White populations. [20][21][22] In a cross-sectional study of a middle-aged and elderly population, skin pigmentation (as well as age, female sex, body mass index, outside temperature, eczema, and chemotherapy) were significant determinants for both generalized and localized dry skin.…”

Section: Skin Barrier Differences Between Racial/ethnic Populations May Contribute To Variations In the Prevalence And Severity Of Atopicmentioning

confidence: 99%

“…19,20 Prevalence and impact of pruritus have also been greater in Blacks than White populations. [20][21][22] In a cross-sectional study of a middle-aged and elderly population, skin pigmentation (as well as age, female sex, body mass index, outside temperature, eczema, and chemotherapy) were significant determinants for both generalized and localized dry skin. Individuals with Brown-Black skin color were more likely to have generalized dry skin than the reference group of olive to light brown skin color.…”

Section: Skin Barrier Differences Between Racial/ethnic Populations May Contribute To Variations In the Prevalence And Severity Of Atopicmentioning

confidence: 99%

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Racial/Ethnic Variations in Skin Barrier: Implications for Skin Care Recommendations in Skin of Color

Alexis¹,

Woolery‐Lloyd²,

Williams³

et al. 2021

JDD

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Background: Genetic and environmental factors influence stratum corneum (SC) barrier properties and function. Researchers increasingly focus on biophysical studies that may help clinicians provide their patients with an informed choice on tailormade skincare. This literature review on skin barrier properties comparing different ethnic populations aims to offer insights into the information's clinical relevance. Methods: A literature review followed by panel discussions and an online review process aimed to answer the questions: Are there racial/ethnic differences in the SC barrier structure and healthy skin barrier function? Is there a need for specific cleansers and moisturizers? Results: Ethnic categories based on race and ethnicity are often not well defined and inconsistent across different studies. Studies comparing ethnic groups' physical and biochemical skin barrier properties have reported differences in transepidermal water loss (TEWL), skin lipid levels, pH, and mast cell granule size. However, these studies frequently had methodological flaws, mainly were small, and demonstrated conflicting results. The literature suggests racial/ethnic variations in ceramide content, SC structure, and filaggrin mutations. Furthermore, studies have shown a greater burden of pruritus and atopic dermatitis among Black populations. Data on barrier properties in Hispanic/LatinX and South Asian populations are lacking. Conclusion:Robust comparative studies are needed to understand these basic concepts to help tailor skincare and skin of color patients' education.

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Section: Skin Barrier Differences Between Racial/ethnic Populations May Contribute To Variations In the Prevalence And Severity Of Atopicmentioning

confidence: 99%

Section: Skin Barrier Differences Between Racial/ethnic Populations May Contribute To Variations In the Prevalence And Severity Of Atopicmentioning

confidence: 99%

Racial/Ethnic Variations in Skin Barrier: Implications for Skin Care Recommendations in Skin of Color

Alexis¹,

Woolery‐Lloyd²,

Williams³

et al. 2021

JDD

View full text Add to dashboard Cite

show abstract

“…We demonstrated the association between rosacea and IBS, consistent with previous observations in the Danish population. 4 This association was still significant in our study, even after additionally controlling for several confounders such as other GI disorders and doxycycline exposure that may produce IBS-like symptoms. 2,4 This study was limited by a single institution and reliance on ICD diagnoses.…”

mentioning

confidence: 44%

“…4 This association was still significant in our study, even after additionally controlling for several confounders such as other GI disorders and doxycycline exposure that may produce IBS-like symptoms. 2,4 This study was limited by a single institution and reliance on ICD diagnoses. Additionally, our study did not distinguish rosacea subtypes or severity.…”

mentioning

confidence: 44%

Rosacea and upper gastrointestinal disorders: a case‐control study from a large, urban academic centre

Lukac

Pagani

et al. 2021

Acad Dermatol Venereol

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“…[5][6][7] Genetic susceptibility and racial structural variation, such as increased transepidermal water loss, lower skin pH, and larger mast cell sizes in black skin, likely contribute to these disparities. 8 However, existing epidemiological studies are limited by small sample sizes and limited racial and ethnic groups. We aimed to address these limitations by examining the racial and ethnic distributions of multiple CPDs in a large, multicentre cohort.…”

mentioning

confidence: 99%