Pruritus and quality of life in renal transplant patients

Panuccio, Vincenzo; Tripepi, Rocco; Bellantoni, Marianna; Saporito, Licia; Quattrone, Serena; Lacava, Viviana; Parlongo, Giovanna; Tripepi, Giovanni; Mallamaci, Francesca; Zoccali, Carmine

doi:10.1111/ctr.12893

Cited by 11 publications

(13 citation statements)

References 20 publications

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“…Moreover, according to Altmeyer et al (25), both itch and histopathological changes disappeared completely after KTx. In comparison to Panuccio et al (9), we have reported a much lower itch prevalence (32% of RNRs). Nevertheless, it was still higher than in the healthy controls (11%).…”

Section: Discussioncontrasting

confidence: 89%

“…Kidney transplant (KTx) is considered the best renal replacement therapy; however, its influence on itch was not sufficiently studied (8). The available data suggest that renal transplant recipients (RTR) may suffer from itch less frequently than patients treated with hemodialysis (9)(10)(11). Due to the insufficient reports and observations on small groups, we have decided to conduct a study and assess an actual prevalence of itch in RTR.…”

Section: Introductionmentioning

confidence: 99%

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Clinical Characteristics of Itch in Renal Transplant Recipients

et al. 2021

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Background: Chronic itch is the most common symptom in dermatology. End-stage renal disease-associated chronic itch (ESRDCI) is a common burden affecting up to 35% of patients treated with hemodialysis. Kidney transplant (KTx) is believed to be the best renal replacement therapy leading to the elimination of ESRDCI. The study was undertaken to characterize and assess the prevalence of itch among patients after renal transplantation.Methods: Between October 2019 and January 2020, we analyzed the data of 197 patients comprising 121 males (61.4%) and 76 females (38.6%) and aged 54.5 ± 13.6 years. The data collection was performed with a specially designed questionnaire. Level of itch after renal transplantation was assessed with the use of a Numeral Rating Scale, a Visual Rating Scale, and 4-Item Itch Questionnaire. Moreover, the previous 3 days of itching were evaluated.Results: The patients suffered from chronic renal disease for 20.2 ± 12.3 years, with a mean time of pre-transplant dialysis of 2.6 ± 2.4 years and a mean time after the KTx of 8.0 ± 6.5 years. The itch was present in 38.6% of the patients during the hemodialysis, and in 73.7% of cases, the itch ceased completely after the successful transplantation. Moreover, only 2.63% of the cases had no improvement. Nevertheless, the itch was reported in 42 (21.3%) renal transplant recipients (RTR), and in 22 (52.4%) cases, the itch appeared after transplantation. The majority of patients suffering from itch were women (54.8%). Itch in the last 3 days was reported in 21 patients. The itch's severity was assessed with a numerical rating scale (NRS), with the worst severity measured at 6 ± 2.2 points indicating moderate itch. In most cases (57.1%), itch affected multiple body areas. Extremities (50%) and the back (50%) were among the most frequently affected areas. The sensation had a mostly short duration and was most frequently reported in the evening. Only eight patients suffered for the whole day. Hot water was the most frequently reported (16.7%) alleviating factor, whilst sweat was responsible for itch aggravation in 35.9% of cases.Conclusion: Our analysis on representative patients' population indicates that itch after KTx is an important problem. Moreover, it is worth noting that more than half of the RTR did not suffer from itch during dialysis.

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Section: Discussioncontrasting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Clinical Characteristics of Itch in Renal Transplant Recipients

et al. 2021

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“…Following RTx, still no guarantee can be made on the disappearance of CKD-aI. Nevertheless, it bothers significantly lower fraction of adult patients than previously [ 26 , 27 , 28 ]. Based on our personal experience, children initially suffering from CKD-aI also benefit from RTx, with the majority of young recipients finally free from this symptom (unpublished data).…”

Section: Management Of Ckd-ai In Childrenmentioning

confidence: 98%

“…Based on recent data, it affects 42–44% of adults undergoing haemodialysis (HD) [ 22 , 23 ], while in patients undergoing peritoneal dialysis (PD) the percentages exceed 60% [ 24 , 25 ]. Patients who underwent successful renal transplantation (RTx) still complain of CI in up to 32% cases, albeit the percentages are lower than during their previous HD sessions [ 26 , 27 , 28 ]. However, CKD-aI may also bother CKD patients not yet on dialysis, including those with earlier stages of the disease [ 23 , 29 , 30 ].…”

Section: Introductionmentioning

confidence: 99%

Chronic Kidney Disease-Associated Itch (CKD-aI) in Children—A Narrative Review

Reszke

Kiliś‐Pstrusińska

Szepietowski

2021

Toxins

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Chronic kidney disease (CKD) is a condition of widespread epidemiology and serious consequences affecting all organs of the organism and associated with significant mortality. The knowledge on CKD is rapidly evolving, especially concerning adults. Recently, more data is also appearing regarding CKD in children. Chronic itch (CI) is a common symptom appearing due to various underlying dermatological and systemic conditions. CI may also appear in association with CKD and is termed chronic kidney disease-associated itch (CKD-aI). CKD-aI is relatively well-described in the literature concerning adults, yet it also affects children. Unfortunately, the data on paediatric CKD-aI is particularly scarce. This narrative review aims to describe various aspects of CKD-aI with an emphasis on children, based on the available data in this population and the data extrapolated from adults. Its pathogenesis is described in details, focusing on the growing role of uraemic toxins (UTs), as well as immune dysfunction, altered opioid transmission, infectious agents, xerosis, neuropathy and dialysis-associated aspects. Moreover, epidemiological and clinical aspects are reviewed based on the few data on CKD-aI in children, whereas treatment recommendations are proposed as well, based on the literature on CKD-aI in adults and own experience in managing CI in children.

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“…Pruritus also has a negative impact on quality of life (QoL) in dialysis patients. If pruritus was evaluated objectively using the Visual Analogue Scale (VAS), the Visual Rating Scale (VRS), and the Numerical Rating Scale (NRS), it was found that prevalence of pruritus markedly reduces after renal transplantation but remains substantially higher than in the general population and impacts upon quality of life in these patients [28].…”

Section: Quality Of Life Of Recipientsmentioning

confidence: 99%

Quality of Life Considerations in 'Caregiver' Renal Donors in Countries with High Living Donor Ratios: A Narrative Review

Agarwal¹

2018

JOJUN

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Live donation in India follows a specific pattern; blood relatives (parents, grandparents, siblings) or spouses (mainly wives) are the main donors. The ratio of female: male donors is also high (>8:1). Ingrained cultural practices like close family bonds and joint families encourage this trend. The government, seeing the behavioral pattern in society, kept these norms in mind while formulating The Transplantation of Human Organs Act, 1994, along with its subsequent modifications [2].

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Pruritus and quality of life in renal transplant patients

Abstract: The prevalence of pruritus markedly reduces after renal transplantation but remains substantially higher than in the general population and impacts upon quality of life in these patients.

Cited by 11 publications

References 20 publications

Clinical Characteristics of Itch in Renal Transplant Recipients

Clinical Characteristics of Itch in Renal Transplant Recipients

Chronic Kidney Disease-Associated Itch (CKD-aI) in Children—A Narrative Review

Quality of Life Considerations in 'Caregiver' Renal Donors in Countries with High Living Donor Ratios: A Narrative Review

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