Pruritus and quality of life in moderate‐to‐severe plaque psoriasis: <i>post hoc</i> explorative analysis from the <scp>PRISTINE</scp> study

Mrowietz, Ulrich; Chouela, Edgardo; Mallbris, Lotus; Stefanidis, D.; Marino, Valentina; Pedersen, Ronald; Boggs, Robert

doi:10.1111/jdv.12761

Cited by 78 publications

(90 citation statements)

References 30 publications

(53 reference statements)

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“…Of the group of dermatoses, it is of interest that psoriasis was searched for as frequently as atopic dermatitis, once more supporting the role of pruritus in this disease. Although a neglected area of medicine, recent studies have demonstrated the frequency and burden of psoriatic itch . Interestingly, certain localizations were more prominent than others.…”

Section: Discussionmentioning

confidence: 99%

Medical needs and major complaints related to pruritus in Germany: a 4‐year retrospective analysis using Google AdWords Keyword Planner

Zink

Schuster

Rüth

et al. 2018

Acad Dermatol Venereol

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Section: Discussionmentioning

confidence: 99%

Medical needs and major complaints related to pruritus in Germany: a 4‐year retrospective analysis using Google AdWords Keyword Planner

Zink

Schuster

Rüth

et al. 2018

Acad Dermatol Venereol

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“…On questionnaires, patients have often labelled itch in psoriasis as ‘bothersome’, ‘annoying’, ‘unbearable’ and ‘worrisome’ . In fact, clinical evidence has shown that itching can significantly impair health‐related quality of life, with itch severity correlating well with the magnitude of impairment . Many aspects of psychosocial well‐being are affected by itch.…”

Section: Burden Of Itch In Psoriasismentioning

confidence: 99%

“…Dealing with itch can lead to increased feelings of agitation, embarrassment, and stigmatization and contribute to stress‐related disorders, anxiety and depression . Mood, concentration, sexual desire and appetite are also affected by the severity of itch . Patients with itchy skin will have disrupted sleep patterns that can lead to itch‐related sleeping disorders, with a consequent negative impact on work productivity through impairment in activity functions .…”

Section: Burden Of Itch In Psoriasismentioning

confidence: 99%

Itch: an under‐recognized problem in psoriasis

Elewski

Alexis

Lebwohl

et al. 2019

Acad Dermatol Venereol

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Psoriasis has historically been considered a nonpruritic dermatosis, in contrast with atopic dermatitis. Thus, itch has often been underappreciated and overlooked in psoriasis. However, increasing evidence over the past decade has shown that itch can be one of the most prevalent and burdensome symptoms associated with psoriasis, affecting almost every patient to some degree. Itch can involve the entire body, although it predominantly affects the legs, hands, back, body and especially the scalp. Uncontrolled itch can significantly impact all aspects of the well‐being and quality of life of the patient. While there has been some progress in trying to better understand the pathophysiology of itch in psoriasis, more research effort and interest are needed. This under‐recognition of itch in psoriasis is clearly reflected in the dearth of treatment options targeting itch despite significant advancement in treating the lesions themselves. Recently, however, clinical studies have begun to include itch as a study outcome. The resulting data have demonstrated concomitant antipruritic benefits and improved Psoriasis Area and Severity Index (PASI) scores with mainstay treatments for psoriasis, such as topical corticosteroids and vitamin D analogs, phototherapies, and various systemics and biologics. This article takes a closer look at this debilitating symptom, reviewing the available epidemiology data for psoriatic itch, presenting the current understanding of psoriatic itch pathophysiology and highlighting important clinical data for various treatment options for itch. Practical considerations for increasing the recognition of itch as well as improving its management in psoriasis are also provided.

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“…One study documented the efficacy of narrowband ultraviolet B (UVB) therapy in treating psoriatic itch. Biologics, like etanercept, may also be of value to reduce pruritus intensity (Mrowietz et al, 2015). However, in some patients, narrowband UVB may aggravate itch by increasing skin dryness, and UVB therapy should be supplemented with moisturizers or emollients (Dawn and Yosipovitch, 2006).…”

Section: Treatment Of Pruritus In Psoriasismentioning

confidence: 99%