Pruritus and Atopic Dermatitis: from Etiological Features to Management

Мурашкин, Н. Н.; Опрятин, Л. А.; Епишев, Р. В.; Материкин, А. И.; Амбарчян, Э. Т.; Иванов, Р. А.; Федоров, Д. В.; Куколева, Д. С.

doi:10.15690/vsp.v19i6.2151

Cited by 7 publications

(2 citation statements)

References 70 publications

(65 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, the oral dosage of drugs may have certain side effects, while topical ointments often require repeated application, which is not convenient enough. [1,2] Therefore, to find a more effective and convenient treatment method, researchers began to pay attention to the topical antipruritic spray (TAS) that acts as an inhibitor of epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI). The drugs are directly applied to the affected part by spray, which can be quickly absorbed and play the role of relieving itching.…”

Section: Introductionmentioning

confidence: 99%

Clinical observation of topical antipruritic spray acting on epidermal growth factor receptor tyrosine kinase inhibitor in the treatment of dermatitis

Fu,

Li,

Wang

et al. 2024

Medicine

View full text Add to dashboard Cite

To observe the efficacy of topical antipruritic spray (TAS) in the treatment of epidermal growth factor receptor (EGFR) tyrosine kinase-related rashes, and to evaluate its efficacy and safety. 120 malignant tumor patients with confirmed pathological diagnosis and rash after EGFR application were selected and randomly divided into an experimental group of 60 cases and a control group of 60 cases. The 2 groups were intervened with self-made antipruritic spray and erythromycin ointment for 14 consecutive days. To observe the changes in rash, itching degree, and quality of life index of skin diseases in both groups of patients before and after treatment. The decrease in the number of itching cases in the experimental group reached 53.84%, and after 7 weeks of intervention, the total effective rate of rash treatment in this group of patients (91.67%) was significantly better than that in the control group (36.67%); The symptoms of the dermatology life quality index (DLQI) scale in the experimental group patient table after intervention showed significant changes compared to before intervention. After statistical testing, there was a significant difference between the groups and outside the group (R < 0.05). And the comprehensive effect of the experimental patients with external spray after 14 weeks of intervention reached 93.16%. The self-made antipruritic spray has significant effect on improving EGFR rash and itching, and there is no obvious adverse reaction.

show abstract

Section: Introductionmentioning

confidence: 99%

Clinical observation of topical antipruritic spray acting on epidermal growth factor receptor tyrosine kinase inhibitor in the treatment of dermatitis

Fu,

Li,

Wang

et al. 2024

Medicine

View full text Add to dashboard Cite

show abstract

“…ИМП «Зиртек» 10 мг таб., ПN014186/01, дата обновления 26.10.2020 2. ИМП «Кларитин» 10 мг таб., ПN013494/01, дата обновления 24.01.2018 3. ИМП «Эриус» 5 мг таб., ПN014704/02, дата обновления 16.04.2021 4.…”

unclassified

Place of anti-histamine in therapy of itching skin of children

Masalskiy

Smolkin²

2021

Allergol. immunol. pediatr.

View full text Add to dashboard Cite

Itching is a frequent condition at a doctor's appointment of any speciality. A quarter of patients complain of itching of various etiology. In real practice, H1-histamine receptor blockers are prescribed for itching in the first place. The article considers a complex of diseases accompanied by itching of the skin. The itching is a reflex. The classification contains a lot of forms:local and systemic; prurigogenic, neuropathic and psychogenic. Itching has no stable pathogenesis and can be provoked by various conditions. The main types of sensory neurons are opiate and 5-HT-receptors. Urticaria and food allergy are associated with irritation of the skin receptors with histamine and other mast cell mediators. In these cases, antihistamines are the drug of choice regardless of the aetiology of urticaria. In atopic dermatitis, the itching has a complex aetiology: transepidermal water loss, chronic inflammation of the skin with the participation of many cells, secondary hyperinervation of the skin with the formation of a pathological activity focus in the brain. This requires a comprehensive approach to therapy. Xerosisis overcome by the use of emollients and rational skincare. The presence of exacerbation makes it necessary to prescribe topical steroids or calcineurin inhibitors for an acute period s. In the case of the addition of psychogenic itching, antiserotonin 5-HT-blockers drugs, hydroxyzine can be considered. H1-receptor blockers do not affect the intensity of skin lesions in dermatitis, but some molecules can reduce the itching. Quifenadine is the antihistamine dug of the second generation. It can be used in the treatment of allergic itching dermatoses. The rapid onset of action allows you to reach the maximum concentration in the tissues within 1 hour, activate monooxidase and neutralise histamine in the tissue. Quifenadine absence a sedative effect and no respiratory depression.Instructions for the use of the medicinal product can increase the dose by 1,5–2 times.It makes the drug useful for the treatment of manifestations of food allergies and urticaria. The dual antihistamine and antiserotonin action allow the successful use of quifenadine in the acute period of atopic dermatitis, especially provoked by contact with an allergen.

show abstract

Skin Microbiome Composition and Key Factors of its Barrier Function

Murashkin,

Pavlova,

Epishev

et al. 2023

Vopr. sovr. pediatr.

View full text Add to dashboard Cite

The skin is the largest organ of the human body, it creates protective barrier between the internal and external environment. Skin barrier damage may result in homeostasis imbalance, inflammation, or bacterial infection. The microbiome plays a crucial role in maintaining normal skin functioning: control of pathogenic diversity of microorganisms, stimulate immune cells, and modulate chronic dermatoses development. There are various mechanisms for restoring skin barrier function. They are associated with the microorganisms’ activity. Thus, skin restoration is an important task included in the general concept of atopic dermatitis management. One of such methods is the skin surface colonization with commensals, so significant role is assigned to the new dermatological drugs. The normalization of the microbiome in affected skin areas with cosmetic care products can significantly affect the result of skin barrier restoration.

show abstract

Pruritus and Atopic Dermatitis: from Etiological Features to Management

Cited by 7 publications

References 70 publications

Clinical observation of topical antipruritic spray acting on epidermal growth factor receptor tyrosine kinase inhibitor in the treatment of dermatitis

Clinical observation of topical antipruritic spray acting on epidermal growth factor receptor tyrosine kinase inhibitor in the treatment of dermatitis

Place of anti-histamine in therapy of itching skin of children

Skin Microbiome Composition and Key Factors of its Barrier Function

Contact Info

Product

Resources

About