Pruritic urticarial papules and plaques of pregnancy: Clinical and immunopathologic observations in 57 patients

Aronson, Iris K.; Bond, Shirley; Fiedler, Virginia C.; Vomvouras, Stephanie; Gruber, David; Ruiz, Catherine

doi:10.1016/s0190-9622(98)70265-8

Cited by 153 publications

(121 citation statements)

References 31 publications

Supporting

Mentioning

107

Contrasting

Unclassified

Order By: Relevance

“…similar findings have been observed by other authors (2,3,6). DiF studies are also required to differentiate pemphigoid gestationis from other cutaneous lesions occurring in pregnancy, especially pruritic urticarial papules and plaques of pregnancy, the latter showing negative results on DiF (6).…”

Section: Resultssupporting

confidence: 86%

Utility of direct immunofluorescence studies in subclassification of autoimmune sub-epidermal bullous diseases: a 2-year study in a tertiary care hospital

Basavaraj¹,

Vimala²

2016

TJPATH

View full text Add to dashboard Cite

Objective: sub-epidermal bullous disorders belong to immunobullous diseases which develop as a result of autoantibody action against epidermal basement membrane proteins. Clinically, they are tense bullae and do not rupture easily. They are classified into various forms based on histopathology and direct immunofluorescence patterns. This study was undertaken to assess the incidence of various sub-epidermal bullous disorders and the utility of direct immunofluorescence in accurately classifying them, and to study the intensity and pattern of immunofluorescence in various sub-epidermal bullous disorders Material and Method: a 2-year study of 38 cases of sub-epidermal bullous disorders sent for direct immunofluorescence studies formed the study group. The specimens were processed as per standard protocols. The clinical details were obtained from case files and requisition sent for histopathological and direct immunofluorescence studies.Results: Thirty-eight patients were diagnosed to have sub-epidermal bullous disorders over the period of 2 years. Twenty five cases of Bullous Pemphigoid, 5 cases of Dermatitis Herpetiformis, 3 cases of linear iga Bullous disorder, 2 cases of Bullous systemic lupus Erythematoses and 1 case each of Epidermolysis Bullosa acquisita, Cicatricial Pemphigoid and Pemphigus gestationis was diagnosed. Positive direct immunofluorescence was seen in 91.3% of the cases. Conclusion:Histopathology alone cannot classify sub-epidermal bullous disorders and direct immunofluorescence studies are mandatory in all of them. Bullous Pemphigoid needs to be distinguished from Epidermolysis Bullosa acquisita which requires salt split direct immunofluorescence studies. Dermatitis Herpetiformis, Bullous systemic lupus Erythematosus and linear iga Bullous disorder show more or less similar histological picture with neutrophilic microabscess. Direct immunofluorescence studies help in the majority of cases but further testing such as immunoblotting, immunoelectron microscopy or indirect immunofluorescence becomes essential in cases with overlapping features.

show abstract

Section: Resultssupporting

confidence: 86%

Utility of direct immunofluorescence studies in subclassification of autoimmune sub-epidermal bullous diseases: a 2-year study in a tertiary care hospital

Basavaraj¹,

Vimala²

2016

TJPATH

View full text Add to dashboard Cite

show abstract

“…Consequently, the clinical and histologic similarities between PG and PUPPP are considerable, and differentiating between these entities may be extremely difficult. [18][19][20][21][22] The distinction is nonetheless important, because the clinical course of PG is substantially different from that of PUPPP. In contrast to patients with PUPPP, patients with PG experience a high recurrence rate in subsequent pregnancies (often more clinically severe) and may require more intense immunosuppression.…”

Section: Discussionmentioning

confidence: 99%

Clinical experience in pemphigoid gestationis: Report of 10 cases

Castro

Lundell

Krause

et al. 2006

Journal of the American Academy of Dermatology

View full text Add to dashboard Cite

“…Pruritic urticarial papules and plaques of pregnancy (PUPPP) is the most common dermatosis of pregnancy, and is also known as toxemic rash or polymorphic eruption of pregnancy. Pruritic urticarial papules and plaques occur in 1 of 160 to 240 pregnancies, and are more common in white women [10]. Classically, this disease occurs in primigravidas during the third trimester, and the incidence is higher in multiple gestations (ie, 0.5% of single births, 2.9% of twin pregnancies, and 14% of triplets) [11].…”

Section: Sr Nomentioning

confidence: 99%

A study on dermatoses of pregnancy

Puri¹,

Puri²

2013

Our Dermatol Online

View full text Add to dashboard Cite

Certain dermatoses are specifically seen in pregnancy or postpartum period. It is therefore important for the clinicians to recognize and treat these cutaneous disorders to minimize maternal and fetal morbidity. The commonest pregnancy related dermatoses was polymorphic eruption of pregnancy seen in 22% patients, prurigo of pregnancy was seen in 7% patients, pemphigoid gestationis was seen in 3% patients, pruritic folliculitis of pregnancy was seen in 2% patients and intrahepatic cholestasis was seen in 1% of patients. It was seen that the skin disorders were commonest in the third trimester (60%), followed by 31% patients in second trimester and 9% patients in first trimester.

show abstract

Pruritic urticarial papules and plaques of pregnancy: Clinical and immunopathologic observations in 57 patients

Cited by 153 publications

References 31 publications

Utility of direct immunofluorescence studies in subclassification of autoimmune sub-epidermal bullous diseases: a 2-year study in a tertiary care hospital

Utility of direct immunofluorescence studies in subclassification of autoimmune sub-epidermal bullous diseases: a 2-year study in a tertiary care hospital

Clinical experience in pemphigoid gestationis: Report of 10 cases

A study on dermatoses of pregnancy

Contact Info

Product

Resources

About