Abstract:Bleomycin is an antineoplastic drug used in the treatment of different tumors. It has several side effects, including a cutaneous hyperpigmentation with a flagellate aspect, which is considered specific to Bleomycin. We report two cases of Bleomycin-induced flagellate dermatitis and discuss the clinical and etiopathogenic aspects in a brief blibliographic revision. Keywords: Bleomycin; Chemotherapy; Hodgkin's disease
CommunicationBleomycin is an antibiotic with an antineoplastic citotoxic property. It has been used in the treatment of a variety of tumors, including Hodgkin's lymphoma, testes carcinoma and head and neck squamous cell carcinoma. Several non-specific reactions associated with the use of bleomycin have been described and they include stomatitis, alopecia, lung fibrosis, Raynaud1s phenomenon, ungueal deformities, palmplantar ulcers, bullous lesions, sclerodermy, hyperkeratosic verrucous plaques and inflammatory nodules.