Prurigo pigmentosa: An underdiagnosed disease in patients of Iranian descent?

Prurigo pigmentosa: a clinicopathological study and analysis of associated factors

“…According to descriptions from Böer et al. , 2,3 superficial perivascular infiltration of neutrophils appears in early lesions as urticarial papules, followed by collections of neutrophils in the epidermis. Fully developed lesions are comprised of papules, papulovesicles, and vesicles.…”

“…(Table 1) . 2,3 Patients without histopathological confirmation of skin lesions were excluded. Data noted from a medical record review included demographics, disease duration, site and extent of disease, signs and symptoms of disease, laboratory examination (including whole blood cell count, serum glucose, serum immunoglobulin‐E, antinuclear antibodies, urinary analysis, serum and tissue antibodies against Borrelia burgdorferi ), histopathology, disease treatment, treatment duration, treatment response, and other associated findings.…”

An itchy rash in a young Caucasian woman

“…Most reports are of Japanese patients, while the disease is rarely diagnosed outside Japan. It has been subject to discussion if this reflects a higher incidence in the Japanese population or if the disease is underdiagnosed in other countries [2]. …”

Disorders of pigmentation

“…657 This stage resolves within days, leaving a mottled or reticulate hyperpigmentation. [664][665][666][667] Ketosis has also been implicated. The average age of onset is between 23 and 27 years.…”

“…663 It is uncommon in the Western world, although over 50 cases have now been reported. 666,667,673 Doxycycline, macrolide antibiotics, isotretinoin, 674 and dapsone have also been used to treat this condition. [668][669][670] Its association with Helicobacter infection may have been fortuitous.…”