Prurigo pigmentosa: A Possible Mechanism of Action of Sulfonamides

Yoshioka, Akira; Horio, Takeshi; Imamura, Sadao; Niwa, Yukie

doi:10.1159/000249303

Cited by 38 publications

(22 citation statements)

References 12 publications

(16 reference statements)

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“…Most patients respond poorly to topical steroids or oral antihista mines. Miyachi et al [ 18] proposed that dapsone and other sulfonamides might exert its anti-inflammatory effects by affecting oxygen-intermediate generation induced by a so far unidentified allergen. Minocycline is thought to have the same anti-inflammatory properties through inhibition of oxygen intermediates in inflammation.…”

Section: Discussionmentioning

confidence: 99%

Prurigo pigmentosa

Liu¹,

Wong²

1994

Dermatology

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Prurigo pigmentosa is a rare dermatosis with unknown etiology. It is characterized clinically by severe pruritic red papules and reticulate pigmentation thought to be an entity occurring more commonly in Japan where nearly 200 cases have been reported [1]. Outside Japan, only 7 cases have been described [2–7]. In Taiwan, though geographically close to Japan, no single case of this peculiar disorder has been reported. We herein describe a typical case in a Chinese and review the literature.

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Section: Discussionmentioning

confidence: 99%

Prurigo pigmentosa

Liu¹,

Wong²

1994

Dermatology

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“…Historically, Japanese authors were the first in 1983 to attribute an oxygen-radical scavenging ability to dapsone [112–115, 121, 161]. In the works of this group, dapsone was shown to effectively lower the concentrations of H 2 O 2 and of OH − as well as the activity of chemiluminescence when these parameters were studied during the process of oxidative activation PMN.…”

Section: Anti-inflammatory Mechanisms Of Actionmentioning

confidence: 99%

Dapsone in dermatology and beyond

2013

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Dapsone (4,4′-diaminodiphenylsulfone) is an aniline derivative belonging to the group of synthetic sulfones. In 1937 against the background of sulfonamide era the microbial activity of dapsone has been discovered. Shortly thereafter, the use of dapsone to treat non-pathogen-caused diseases revealed alternate antiinflammatory mechanisms that initially were elucidated by inflammatory animal models. Thus, dapsone clearly has dual functions of both: antimicrobial/antiprotozoal effects and anti-inflammatory features similarly to non-steroidal anti-inflammatory drugs. The latter capabilities primarily were used in treating chronic inflammatory disorders. Dapsone has been investigated predominantly by in vitro methods aiming to get more insights into the effect of dapsone to inflammatory effector cells, cytokines, and/or mediators, such as cellular toxic oxygen metabolism, myoloperoxidase-/halogenid system, adhesion molecules, chemotaxis, membrane-associated phospholipids, prostaglandins, leukotrienes, interleukin-8, tumor necrosis factor α, lymphocyte functions, and tumor growth. Moreover, attention has been paid to mechanisms by which dapsone mediates effects in more complex settings like impact of lifespan, stroke, glioblastoma, or as anticonvulsive agent. Additionally, there are some dermatological investigations in human being using dapsone and its metabolites (e.g., leukotriene B4-induced chemotaxis, ultraviolet-induced erythema). It could be established that dapsone metabolites by their own have anti-inflammatory properties. Pharmacology and mechanisms of action are determining factors for clinical use of dapsone chiefly in neutrophilic and/or eosinophilic dermatoses and in chronic disorders outside the field of dermatology. The steroid-sparing effect of dapsone is useful for numerous clinical entities. Future avenues of investigations will provide more information on this fascinating and essential agent.

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“…[48] Other established treatments include sulfonamides (dapsone, sulfamethoxazole), macrolide antibiotics (clarithromycin, roxythromycin), potassium iodide, and isotretinoin. [52] CONCLUSION CONCLUSION…”

Section: Treatment and Prognosismentioning

confidence: 99%

Reticulate pigmentary disorders

Sardana¹,

Goel²,

Chugh³

2013

Indian J Dermatol Venereol Leprol

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Reticulate pigmentary disorders is a term that is loosely defined to include a spectrum of acquired and congenital conditions with different morphologies. The presentations vary from the reticular or net like pattern to the" freckle like" hyper and hypopigmented macules that are usually restricted to the true genetic "reticulate" pigmentary disorders. There is little clarity on this topic and related terms, in major dermatology textbooks. Hence, to harmonize the different entities we feel that the term "mottled pigmentation" could be used to include reticulate pigmentary disorders (acquired and congenital), dyschromasias and the disorders with a reticular pattern. The genetic reticulate pigmentary disorders can also be classified according to the gene loci which in the majority of cases are localized to keratin 5/14. A more useful clinical method of classification is based on the regional distribution, which includes facial, truncal, acral or flexural types. In this review we will largely focus on the inherited reticulate pigmentary disorders.

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Prurigo pigmentosa: A Possible Mechanism of Action of Sulfonamides

Cited by 38 publications

References 12 publications

Prurigo pigmentosa

Prurigo pigmentosa

Dapsone in dermatology and beyond

Reticulate pigmentary disorders

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