Prurigo nodularis of Hyde: an update

Accioly-Filho, L W; Nogueira, Ana; Ramos‐e‐Silva, Márcia

doi:10.1046/j.1468-3083.2000.00021.x

Cited by 44 publications

(52 citation statements)

References 81 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Prurigo nodularis often is associated with atopic dermatitis, allergic contact dermatitis, and psychological pruritus. 46 Lichen simplex chronicus occurs from rubbing and scratching specific areas chronically. It is most frequently seen in elderly patients.…”

Section: Dry Skinmentioning

confidence: 99%

What lies beneath the surface of the itch in adults?

Weldon¹

2007

allergy asthma proc

View full text Add to dashboard Cite

Pruritus is synonymous with itching. Many medical conditions are complicated by chronic pruritus compromising the patient's quality of life. The majority of pruritic stimuli are transmitted through C fibers into the lateral spinothalamic tract and then into the somatic sensory cortex where the itching is detected. Histamine, substance P, and tumor necrosis factor a play significant roles in the perception of pruritus. Medical conditions in adults with significant pruritus will be defined in this review.

show abstract

Section: Dry Skinmentioning

confidence: 99%

What lies beneath the surface of the itch in adults?

Weldon¹

2007

allergy asthma proc

View full text Add to dashboard Cite

show abstract

“…A variety of systemic conditions have been reported to be associated with PN, including emotional stress, anemia, hepatic dysfunction, uremia, myxoedema, venous stasis, folliculitis, nummular eczema, lympjoma, HIV infection, perforating collagenoses, gluten-sensitive enteropathy, and contact dermatitis among others. [1234] It has been observed that approximately 65-80% of PN patients are atopic. [5]…”

Section: Introductionmentioning

confidence: 99%

Oral ketotifen and topical antibiotic therapy in the management of pruritus in prurigo nodularis: A randomized, controlled, single-blind, parallel study

Sharma¹

2013

Indian J Dermatol

View full text Add to dashboard Cite

Aims:To evaluate the role of oral ketotifen and topical antibiotic therapy in the management of pruritus in prurigo nodularis (PN) patients.Materials and Methods:Twenty-seven patients with PN and a history of atopy with raised IgE were included in this study in a dermatology clinic. All patients had positive growth of Staphylococcus aureus on the lesional skin swab. All patients received topical halobetasol and oral hydroxyzine for 4 weeks. In addition, all patients in the study group received oral ketotifen and topical antibiotic therapy for 4 weeks. Randomization was performed by using a table of random numbers, and the participants were randomly allocated to one of the two groups in the study. The study was a single-blind study, and the blinding was done by the investigator.Results:Of the 14 patients in the study group, 9 had complete relief from pruritus by the end of first week, which was maintained till the end of 4 weeks. In the control group, mild to moderate reduction in the intensity of pruritus in the PN lesions of all patients were noted by the end of the first week. No further improvement in the level of pruritus was noted in the participants during the trial period. The treatment was well tolerated by the patients, and the adverse reactions of drugs were minimal in both groups.Conclusions:This study showed that oral ketotifen and topical antibiotic therapy can be helpful in the management of pruritus in PN patients.

show abstract

“…Treatment of the itch and the lesions of prurigo nodularis is rather problematic, even if the underlying disease is cured completely or at least partly. Therapeutic measures include remoisturizing and cooling ointments as well as local anesthetic formulas, tar ointments, infiltration or occlusive application of steroids, capsaicin and PUVA, UVB, systemic steroids, cyclosporin A, and clofazimine or thalidomide [5,6]. In addition to this, patients receive a systemic therapy with sedative and nonsedative antihistamines, often with only temporary success.…”

Section: Introductionmentioning

confidence: 99%

“…The effectiveness of these therapies is attributed to the suppression of different mediators of the pruritus. For example, neuropeptides may be mediators of the neurogenic inflammation and allergic and inflammatory skin reaction [6]. However, the therapeutic recommendations dealing with these psychoactive drugs reflect assumptions of an additional psychic component.…”

Section: Introductionmentioning

confidence: 99%

Psychosomatic Aspects of Prurigo nodularis – Psychodynamics of Two Cases

Hockmann¹,

Ständer²,

Metze³

et al. 2000

Dermatol Psychosom

View full text Add to dashboard Cite

Based on a psychodynamic interpretation of two case reports, prurigo nodularis is defined as multicausal skin disorder of the elderly. We consider this disease a semi-artifact. Specific neurotic conflicts, generally with depressive symptomatology, center on an altruistic conception of life. From a psychoeconomic perspective this entails self-sacrifice, insufficient self-actualization, and repression and inhibition of aggressive impulses. Psychotherapeutic exploration frequently does not occur until decades after the onset of the illness. Our discussion addresses ‘specificity’ in psychosomatic medicine. We encourage dermatologists interested in psychosomatic phenomena to pay attention specifically to early experiences of loss and separation, as well as strain and excessive demands in the life of patients suffering from prurigo nodularis. Such experiences tend to be minimized due to the altruistic orientation of these patients. The primary manifestation and the actual conflict can be utilized to reconfigure the history of neurotic conflicts.

show abstract

Prurigo nodularis of Hyde: an update

Cited by 44 publications

References 81 publications

What lies beneath the surface of the itch in adults?

What lies beneath the surface of the itch in adults?

Oral ketotifen and topical antibiotic therapy in the management of pruritus in prurigo nodularis: A randomized, controlled, single-blind, parallel study

Psychosomatic Aspects of Prurigo nodularis – Psychodynamics of Two Cases

Contact Info

Product

Resources

About