Pruni Cortex Extract Accelerates Wound Healing in a Mouse Model of Atopic Dermatitis

Nomoto, Mayumi

doi:10.4172/2161-0509.1000220

Cited by 2 publications

(2 citation statements)

References 12 publications

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“…This could have occurred because of all the active compounds contained in JHT having been metabolized by the 72-h time point. Intriguingly, cherry bark extract, a crude drug contained in JHT, was reported to promote the inflammatory response and accelerate wound healing in a mouse model of atopic dermatitis [ 36 ], which suggests that JHT can potentially modify the inflammatory response peak and thus facilitate the treatment of atopic dermatitis. Therefore, in this study, JHT treatment might have only delayed the inflammatory response peak after UVB irradiation and not completely prevented UVB-induced skin damage.…”

Section: Discussionmentioning

confidence: 99%

Oral administration of Jumihaidokuto inhibits UVB-induced skin damage and prostaglandin E2 production in HR-1 hairless mice

Murata¹,

Oyama²,

Ogata³

et al. 2020

J Nat Med

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This study was conducted to investigate whether and how Jumihaidokuto (JHT), a traditional Chinese medicine, prevents UVB-induced skin damage in male HR-1 hairless mice. JHT has been traditionally prescribed for patients presenting skin disorders with redness and swelling, and, in Japan, it is approved for prescription to patients with acute and/or purulent skin disorders, hives, acute eczema, and athlete’s foot. Considering the traditional use of JHT, we hypothesized that oral administration of JHT might emerge as an effective strategy to prevent UVB-induced skin damage, such as edema and erythema. Here, we pretreated mice with JHT (1000 mg/kg, p.o.) for 3 weeks and then administered a single dose of UVB irradiation (250 mJ/cm2) on the dorsal skin. UVB irradiation increased the erythema index and transepidermal water loss (TEWL) and decreased the skin water content in the epidermis at 72 h post-irradiation. JHT treatment inhibited the increase of TEWL and the loss of water content in the epidermis, but not the elevation of the erythema index. Moreover, administration of JHT suppressed UVB-induced epidermal hyperplasia by blocking the proliferation of keratinocytes and also inhibited irradiation-triggered reduction of collagen fibers and infiltration of immune cells into the dermis. Lastly, administration of JHT suppressed UVB-induced production of proinflammatory mediators, such as prostaglandin E2 and interleukin-1β. These results suggest that JHT prevents UVB-induced skin damage and that the underlying mechanism involves the inhibition of proinflammatory mediators.

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Section: Discussionmentioning

confidence: 99%

Oral administration of Jumihaidokuto inhibits UVB-induced skin damage and prostaglandin E2 production in HR-1 hairless mice

Murata¹,

Oyama²,

Ogata³

et al. 2020

J Nat Med

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“…Keishi-Bukuryo-gan effectively alleviates the symptoms of rosacea, possibly because it improves the peripheral blood flow as an anti-Oketsu drug. 13,14,15,16,17) In addition, Yokuinin contains azelaic acid, which is used as a therapeutic agent for rosacea. 18) Moreover, the gut microbiota and traditional Kampo are considered to interact significantly, resulting in therapeutic efficacy.…”

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confidence: 99%

Effects of Keishi-Bukuryo-gan-ka-Yokuinin on Rosacea Model Mice

2022

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Rosacea encompasses a constellation of clinical pathologies, including persistent erythema, inflammatory papulopustular rash, and facial telangiectasias. Additionally, rosacea is considered to be an important risk factor for various diseases, and it has been suggested to be related with inflammatory bowel disease, cardiovascular disease, hyperlipidemia, Parkinson's disease, rheumatoid arthritis, malignant tumor, autoimmune diseases and so on. 1,2,3) The major pathomechanisms of rosacea are environmental triggers (e.g., heat and alcohol) and genetic predisposition, which play a major role in neurovascular dysregulation. Other pathogenic factors of rosacea include ultraviolet radiation, skin barrier dysfunction, demodicosis and infection of Staphylococcus. Moreover, the improper and excessive use of topical corticosteroid creams on the face causes rosacea-like symptoms (steroid-induced rosacea). 4) Recently, some studies have reported the importance of oxidative stress in the pathophysiology of rosacea about vascular lesions, inflammation, and oxidative tissue damage. 5,6,7) The Rosacea Medical Management Guidelines of the American Acne and Rosacea Society 8) recommend certain topical and oral therapies for papules and pustules. Currently, standard medical and surgical therapies for rosacea include topical agents such as azelaic acid, metronidazole, and brimonidine tartrate; systemic doxycycline and isotretinoin; and vascular laser therapy; 9,10) however, the therapeutic effect of the current treatment is rather limited, only palliative for a short span, and cannot prevent recurrence in many cases. In particular, telangiectasia and flushing, the clinical symptoms of rosacea, are only treated with the use of light devices, with weak trial evidence. Similarly, according to the guidelines of the Japanese Dermatological Association, many options for the treatment of acne vulgaris are ranked A ("highly recommended"), while most of the options for treating rosacea are ranked as only either C1 ("conditionally recommended") or C2 ("not recommended"). 11) Therefore, as mentioned above, the treatment recourse for the clinical symptoms of rosacea has not yet been sufficiently established.However, some pharmaceutical-grade traditional Japanese medicines (Kampo) show antioxidative and antibacterial effects, especially the improvement of blood flow, and it has been reported that treatment with a traditional Kampo medicine has alleviated rosacea symptoms in many cases. 12) In Kampo medicine, pathological changes in the capillaries of rosacea patients are considered the "Oketsu" state. 13) Oketsu is similar in concept to blood stasis, but it is the characteristic pathophysiology in traditional Japanese medicine that describes a circulatory disturbance with vascular resistance and blood fluidity.The Keishi-Bukuryo-gan-ka-Yokuinin (KBY) is one of the pharmaceutical-grade traditional Kampo, generally prescribed for Oketsu and has been widely used for the treatment of menstrual irregularity, automatic imbalance syndrome peculiar to wo...

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Pruni Cortex Extract Accelerates Wound Healing in a Mouse Model of Atopic Dermatitis

Cited by 2 publications

References 12 publications

Oral administration of Jumihaidokuto inhibits UVB-induced skin damage and prostaglandin E2 production in HR-1 hairless mice

Oral administration of Jumihaidokuto inhibits UVB-induced skin damage and prostaglandin E2 production in HR-1 hairless mice

Effects of Keishi-Bukuryo-gan-ka-Yokuinin on Rosacea Model Mice

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