Prunart Renal Lymphoma

Dimopoulos, Meletios A.; Moulopoulos, Lia A.; Costantinides, Costantinos; Deliveliotis, Charalambos; Pantazopoulos, D; Dimopoulos, Costantine

doi:10.1097/00005392-199606000-00011

Cited by 3 publications

(4 citation statements)

References 11 publications

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“…2), the diagnosis is not always straightforward. There are many potential mimics, including inflammatory processes with increased lymphocytes, such as inflammatory pseudotumors, abscesses or pyelonephritis [32,33,34,35], or, in post-renal-transplant patients, in acute rejection [36,37,38,39,40]. In addition, although neoplastic cells in renal-cell carcinoma and transitional-cell carcinoma are not typically confused with hematopoietic disease, these tumors may be accompanied by an abundant inflammatory response which may also raise suspicion for lymphoma [41,42].…”

Section: Discussionmentioning

confidence: 99%

Importance of Flow Cytometry in the Cytopathologic Evaluation of Lymphoid Lesions Involving the Kidney

Bynum

Duffield²,

Ali³

2016

Acta Cytologica

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Background: Cytomorphology alone is often insufficient for the diagnosis and subclassification of lymphomas, so flow cytometry (FC) may be used as an adjuvant test. Methods: Renal fine-needle aspirations (FNAs) performed from January 1993 to August 2014 were reviewed for FC data or a diagnosis of lymphoma. Results: A total of 586 renal FNAs were collected. Thirty-three cases (5.1%) had FC analysis. Lymphoma was diagnosed 35 times (6%), and FC was performed in 21 (60%) cases. Both cytomorphology and FC were consistent with lymphoma in 20 cases. Cytomorphology alone was diagnostic of lymphoma in 15 cases. In 28 cases, biopsy from the kidney or another site was diagnostic of lymphoma. One subsequent biopsy revealed that a kidney FNA, which showed no definitive morphologic or FC evidence of lymphoma, likely represented necrotic diffuse large B-cell lymphoma. Conclusion: FC is a useful adjuvant diagnostic test for renal FNAs, particularly for subclassification and confirmation of the diagnosis when there is insufficient material for immunohistochemistry. FC should be interpreted with caution when a sample is limited or when there is suspicion of Hodgkin lymphoma, and further work-up is warranted when cytomorphology suggests lymphoma but FC is negative.

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Section: Discussionmentioning

confidence: 99%

Importance of Flow Cytometry in the Cytopathologic Evaluation of Lymphoid Lesions Involving the Kidney

Bynum

Duffield²,

Ali³

2016

Acta Cytologica

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“…Lenalidomide was dissolved in DMSO as per manufacturer's instructions (Sigma Aldrich, St. Louis, MO). It was diluted in media to 2.3µM immediately prior to use [26]. The treated RPMI-8226 cells were mixed with lenalidomide in the syringe and loaded in the microfluidic device following similar procedure as stated above.…”

Section: Activation Of Nk Cells and Nk-mediated Cytolysis In Dropletsmentioning

confidence: 99%

“…We next assessed the feasibility of screening different types of therapeutic agents, including small molecule drugs and antibody-based inhibitors, using our analytical approach. Here we determined the effect of lenalidomide, a small molecule derivative of thalidomide, in modifying the efficacy of NK cell activity in droplets [26]. This drug is known to activate T and NK cells and improve recognition of malignant cells by NK cells [5,38].…”

Section: Increasing Primary Nk Cell Cytotoxicity With Lenalidomidementioning

confidence: 99%

Anti-myeloma activity and molecular logic operation by Natural Killer cells in microfluidic droplets

Sarkar

McKenney

Sabhachandani

et al. 2019

Sensors and Actuators B: Chemical

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Immune-targeted therapies that activate effector lymphocytes such as Natural Killer (NK) cells are currently being investigated for the treatment of Multiple myeloma (MM), the second most common form of hematological cancer. However, individual NK cells are highly heterogeneous in their cytolytic potential, making it difficult to detect, quantify and correlate the outcome of dynamic effector-target cell interactions at single cell resolution. Here, we present a microfluidic bioassay platform capable of activity-based screening of cellular and molecular immunotherapies. We identified distinct functional signatures associated with NK-MM cell interaction. The addition of immunomodulatory drug lenalidomide altered responses of NK-susceptible MM cells but not that of NK-tolerant MM cells. Antitumor cytotoxicity was significantly increased by the blockade of PD1/PDL1 axis as well as the clinically relevant cell line NK92, which were used to construct molecular logic functions (AND and NOT gates). A predictive agent-based mathematical model was developed to simulate progressive disease states and drug efficacy. The findings of the current study validate the applicability of this microfluidic cytotoxicity assay for immunotherapy screening, biocomputation and for future employment in detection of patient-specific cell response for precision medicine.

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“…In one study, MRI of spine detected additional foci in four out of 12 patients. [23] In cases of smouldering MM (smouldering myeloma [SM]), MRI detected marrow abnormalities in 30-50% of patients. Furthermore, in one study it was demonstrated that median time to start treatment was 16 months in patients with abnormal MRI compared to 43 months with normal MRI (P < 0.01).…”

Section: Role Of Mri In Solitary Plasmacytoma/smouldering Mm/monoclonmentioning

confidence: 99%

Imaging Techniques Used in Multiple Myeloma

Hameed

Foran

O’Gorman

et al. 2015

J Cancer Allied Spec

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Multiple myeloma (MM) is a plasma cell disorder, characterised by bone marrow infiltration with clonal plasma cells; production of monoclonal immunoglobulin (paraprotein); end-organ damage; lytic lesions in the bones; renal impairment; hypercalcaemia and anaemia. Skeleton evaluation in MM is necessary not only for staging purposes but also to detect serious complications such as fractures. Skeletal survey is an established rst-line investigation for this purpose. However, in recent years, new imaging techniques such as whole-body magnetic resonance imaging and 2- uoro-2-deoxy-D-glucose positron emission tomography computed tomography have been used widely. In this article, we review different imaging techniques used in MM and their impact on patient management. Key words: Imaging techniques, magnetic resonance imaging, multiple myeloma, osteolytic lesions, positron emission tomography/computed tomography, skeletal survey

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Prunart Renal Lymphoma

Abstract: Primary renal lymphoma is unusual but not rare. The relatively poor prognosis in our patients could be attributed to the adverse prognostic factors associated with aggressive nodal lymphomas.

Cited by 3 publications

References 11 publications

Importance of Flow Cytometry in the Cytopathologic Evaluation of Lymphoid Lesions Involving the Kidney

Importance of Flow Cytometry in the Cytopathologic Evaluation of Lymphoid Lesions Involving the Kidney

Anti-myeloma activity and molecular logic operation by Natural Killer cells in microfluidic droplets

Imaging Techniques Used in Multiple Myeloma

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