Prs9 Quality of Life and Economic Impact of Asthma Control in France and Spain. First Results of the Eu-Coast Study

Chouaïd, C.; Calvo, Corbella E; Com-Ruelle, Laure; Brosa, Max; Doz, M.; Gueron, B.

doi:10.1016/s1098-3015(11)72241-0

Cited by 1 publication

(6 citation statements)

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“…Six publications found strong and consistent correlations between improvement in ACT score and improvement in ACQ score [8][9][10][11][12][13], with five of the publications assessing the statistical significance of the correlations. All five of these reports found statistically significant Number of asthma exacerbations 10 2 26,27 (2) 26,27 8 17,22,23,28-32 (7) 22,23,[28][29][30][31][32] Lung function 17 8 3,15,27,33-37 (5 b ) 3,34-37 9 11,13,18,38-43 (7 b ) 11,13,[38][39][40]42,43 General HRQoL 7 0 (0) 7 [49][50][51][52][53][54][55] (5 b ) 49,50,[52][53][54] Asthma-related QoL 7 5 28,34,[44][45][46] (5) 28,34,44-46 2 47,48 (2) 47,48 Sleep quality 6 2 45,56 (2) 45,56 5 [56][57]…”

Section: Act Score and Asthma Symptom Controlmentioning

confidence: 99%

“…In total, seven studies reported general HRQoL in ACT subgroups, measuring HRQoL by the Short Form (12-item) Health Survey (SF-12) or the EuroQol five dimensions questionnaire (EQ-5D) [49][50][51][52][53][54][55]. In both questionnaires, a higher score indicates improved QoL.…”

Section: Act Score and Qolmentioning

confidence: 99%

“…Additionally, one study reported a significant difference in EQ-5D between patients with "not wellcontrolled" (ACT score < 20) and "well-controlled" (ACT score ≥ 20) asthma (EQ-5D scores, 0.7 vs. 0.9; p < 0.0001) [50]. This finding is of particular interest, given that the EQ-5D system may lack sensitivity which often does not correlate with underlying clinical measures [56,57].…”

Section: Act Score and Qolmentioning

confidence: 99%

“…In total, six studies reported on costs [50,65,70,[76][77][78], of which five reported relationships between asthma control subgroup and direct medical costs [50,65,70,76,77], and three with indirect medical costs [65,77,78]. However, only one study reported statistically significant results for direct medical costs [77].…”

Section: Act Score and Resource Use And Costsmentioning

confidence: 99%

“…The average cost (Euros [€)/month/patient) of wellcontrolled asthma versus "not well-controlled" asthma was reported as €28 versus €140 in France and €77 versus €252 in Spain [50]. In Spain, indirect costs were significantly higher in older patients (41-65 years, €405.08), patients with more severe disease (€698.95), and patients with more poorly controlled asthma (€466.86) [65].…”

Section: Act Score and Resource Use And Costsmentioning

confidence: 99%

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Relationship between the Asthma Control Test (ACT) and other outcomes: a targeted literature review

et al. 2020

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Background: The Asthma Control Test (ACT) has been used to assess asthma control in both clinical trials and clinical practice. However, the relationships between ACT score and other measures of asthma impact are not fully understood. Here, we evaluate how ACT scores relate to other clinical, patient-reported, or economic asthma outcomes. Methods: A targeted literature search of online databases and conference abstracts was performed. Data were extracted from articles reporting ACT score alongside one or more of: Asthma Control Questionnaire (ACQ) score; rescue medication use; exacerbations; lung function; health−/asthma-related quality of life (QoL); sleep quality; work and productivity; and healthcare resource use (HRU) and costs. Results: A total of 1653 publications were identified, 74 of which were included in the final analysis. Of these, 69 studies found that improvement in ACT score was related to improvement in outcome(s), either as correlation or by association. The level of evidence for each relationship differed widely between outcomes: substantial evidence was identified for relationships between ACT score and ACQ score, lung function, and asthma-related QoL; moderate evidence was obtained for relationships between ACT score and rescue medication use, exacerbations, sleep quality, and work and productivity; limited evidence was identified for relationships between ACT score and general health-related QoL, HRU, and healthcare costs. Conclusions: Findings of this review suggest that the ACT is an appropriate measure for overall asthma impact and support its use in clinical trial settings. GlaxoSmithKline plc. study number HO-17-18170.

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